A source unit for the orientation of new students to Boston University

Thesis (Ed.M.)--Boston University, 1948. This item was digitized by the Internet Archive

Alien Registration- Price, Blanche P. (Farmington, Franklin County)

https://digitalmaine.com/alien_docs/19887/thumbnail.jp

Bone mineral density in patients with inherited bone marrow failure syndromes.

BackgroundPatients with inherited bone marrow failure syndromes (IBMFS) may have several risk factors for low bone mineral density (BMD). We aimed to evaluate the prevalence of low BMD in IBMFS and determine the associated risk factors.MethodsPatients with IBMFS with at least one dual-energy X-ray absorptiometry (DXA) scan were evaluated. Diagnosis of each IBMFS, Fanconi anemia (FA), dyskeratosis congenita, Diamond-Blackfan anemia, and Shwachman-Diamond syndrome was confirmed by syndrome-specific tests. Data were gathered on age, height, and clinical history. DXA scans were completed at the lumbar spine, femoral neck, and forearm. BMD was adjusted for height (HAZ) in children (age ≤20 years). Low BMD was defined as a BMD Z-score and HAZ ≤-2 in adults and children, respectively, in addition to patients currently on bisphosphonate therapy.ResultsNine of thirty-five adults (26%) and eleven of forty children (27%) had low BMD. Adults with FA had significantly lower BMD Z-scores than those with other diagnoses; however, HAZ did not vary significantly in children by diagnosis. Risk factors included hypogonadism, iron overload, and glucocorticoid use.ConclusionsAdults and children with IBMFS have high prevalence of low BMD. Prompt recognition of risk factors and management are essential to optimize bone health

Germ Cells Are Not Required to Establish the Female Pathway in Mouse Fetal Gonads

The fetal gonad is composed of a mixture of somatic cell lineages and germ cells. The fate of the gonad, male or female, is determined by a population of somatic cells that differentiate into Sertoli or granulosa cells and direct testis or ovary development. It is well established that germ cells are not required for the establishment or maintenance of Sertoli cells or testis cords in the male gonad. However, in the agametic ovary, follicles do not form suggesting that germ cells may influence granulosa cell development. Prior investigations of ovaries in which pre-meiotic germ cells were ablated during fetal life reported no histological changes during stages prior to birth. However, whether granulosa cells underwent normal molecular differentiation was not investigated. In cases where germ cell loss occurred secondary to other mutations, transdifferentiation of granulosa cells towards a Sertoli cell fate was observed, raising questions about whether germ cells play an active role in establishing or maintaining the fate of granulosa cells. We developed a group of molecular markers associated with ovarian development, and show here that the loss of pre-meiotic germ cells does not disrupt the somatic ovarian differentiation program during fetal life, or cause transdifferentiation as defined by expression of Sertoli markers. Since we do not find defects in the ovarian somatic program, the subsequent failure to form follicles at perinatal stages is likely attributable to the absence of germ cells rather than to defects in the somatic cells.Stem Cell and Regenerative Biolog

Achieving enhanced gain in photorefractive polymers by eliminating electron contributions using large bias fields

Photorefractive polymers have been extensively studied for over two decades and have found applications in holographic displays and optical image processing. The complexity of these materials arises from multiple charge contributions, for example, leading to the formation of competing photorefractive gratings. It has been recently shown that in a photorefractive polymer at relatively moderate applied electric fields the primary charge carriers (holes) establish an initial grating, followed by a subsequent competing grating (electrons) resulting in a decreased two-beam coupling and diffraction efficiencies. In this paper, it is shown that with relatively large sustainable bias fields, the two-beam coupling efficiency is enhanced owing to a decreased electron contribution. These results also explain the cause of dielectric breakdown experienced under large bias fields. Our conclusions are supported by self-pumped transient two-beam coupling and photocurrent measurements as a function of applied bias fields at different wavelengths

Ursinus College Alumni Journal, November 1967

75 years to Pluto • Welcome alumni! Oldtimers return to campus on Homecoming Day • Students cheer Loyalty Fund kick-off • Business & Pleasure • Honored on Founders\u27 Day • Habari safari: Ursinus men go to Africa • Contemporary drama • Development: Ursinus charts a course for the decade ahead • From the President • Birds of a feather gather together • Radio station WRUC entertains and informs the Collegeville community • Florida physician speaks in Yugoslavia • Walter Emerson Baum art show • Campus clippings: Graduate teacher training; Neighborhood dinner; Fall enrollment; End of an era; Parents day; New faculty members; Dutch visitor; Evening school • Sporting scene: Soccer; Hockey; Football; Cross country wins 11 straight • Class notebook • Weddings • Births • In memoriam • The business dollar in educationhttps://digitalcommons.ursinus.edu/alumnijournal/1090/thumbnail.jp

Multiplexed, High Density Electrophysiology with Nanofabricated Neural Probes

Extracellular electrode arrays can reveal the neuronal network correlates of behavior with single-cell, single-spike, and sub-millisecond resolution. However, implantable electrodes are inherently invasive, and efforts to scale up the number and density of recording sites must compromise on device size in order to connect the electrodes. Here, we report on silicon-based neural probes employing nanofabricated, high-density electrical leads. Furthermore, we address the challenge of reading out multichannel data with an application-specific integrated circuit (ASIC) performing signal amplification, band-pass filtering, and multiplexing functions. We demonstrate high spatial resolution extracellular measurements with a fully integrated, low noise 64-channel system weighing just 330 mg. The on-chip multiplexers make possible recordings with substantially fewer external wires than the number of input channels. By combining nanofabricated probes with ASICs we have implemented a system for performing large-scale, high-density electrophysiology in small, freely behaving animals that is both minimally invasive and highly scalable

Ursinus College Alumni Journal, November 1966

\u2770 is here • And \u2770 says: Centennial Fund, roll on! • From the President • For Alumni Association leaders, Homecoming Day was some work and plenty of play • An Ursinus specialty: Shaping the future physician • New placement service for alumni • Huck Finn\u27s dilemma is ours • The paradox of urbia • The theatre of the absurd emerges in Latin America • An age of reforming in liberal education: Trends at Ursinus compare with reforms proposed at Columbia University • Sporting scene: Women undefeated in hockey; Soccer; Cross country; Football • Campus clippings: Founders\u27 Day; Sigma Xi Club; Research at Ursinus; Student teachers; The Agency; Mr. Rue remembers; On army duty; Evening school grows; Neighbors come to dinner; Lindback scholar; Parents Day; Job opportunity; \u2767 Ruby underway • Class notebook • Weddings • Births • In memoriamhttps://digitalcommons.ursinus.edu/alumnijournal/1085/thumbnail.jp