3 research outputs found
Clinical Significance and Place of Laparoscopic Myomectomy in Modern Treatment of Myoma // ΠΠ»ΠΈΠ½ΠΈΡΠ½ΠΎ Π·Π½Π°ΡΠ΅Π½ΠΈΠ΅ ΠΈ ΠΌΡΡΡΠΎ Π½Π° Π»Π°ΠΏΠ°ΡΠΎΡΠΊΠΎΠΏΡΠΊΠ°ΡΠ° ΠΌΠΈΠΎΠΌΠ΅ΠΊΡΠΎΠΌΠΈΡ Π² ΡΡΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΠΎΡΠΎ Π»Π΅ΡΠ΅Π½ΠΈΠ΅ Π½Π° ΠΌΠΈΠΎΠΌΠ½Π°ΡΠ° Π±ΠΎΠ»Π΅ΡΡ
[EN] Over the last 20 years by virtue of achievement of technical progress innovative methods for surgical treatment take place in gynaecological surgery. One of these methods, which continues to be object of scientific research is laparoscopic myomectomy. Since 1990 laparoscopic myomectomy has been an alternative to laparotomy in case of removing of subserous and intramural myomas. Several techniques for laparoscopic myomectomy have been described in the literature. They vary according to equipment and instruments in use; by way of approach and different stages of the operation. In order an exact scientific research and analysis to be performed, introducing of standardized method for laparoscopic myomectomy is needed. Data for intra- and postoperative indicators operative time, hospital stay and blood loss are controversial in scientific publications. Little attention is paid to the factors that affect the duration of the operation. Controversial are the results for the frequency of complications in laparoscopic myomectomy due to the different types of studies (prospective, retrospective, randomized, non- randomized. meta-analysis). When performed by well-trained specialists the risk of perioperative complications doesn't exceed that in standard operative techniques.ΠΡΠ΅Π· ΠΏΠΎΡΠ»Π΅Π΄Π½ΠΈΡΠ΅ 20 Π³ΠΎΠ΄ΠΈΠ½ΠΈ Π±Π»Π°Π³ΠΎΠ΄Π°ΡΠ΅Π½ΠΈΠ΅ Π½Π° ΠΏΠΎΡΡΠΈΠΆΠ΅Π½ΠΈΡΡΠ° Π½Π° ΡΠ΅Ρ
Π½ΠΈΡΠ΅ΡΠΊΠΈΡ ΠΏΡΠΎΠ³ΡΠ΅Ρ Π² Π³ΠΈΠ½Π΅ΠΊΠΎΠ»ΠΎΠ³ΠΈΡΠ½Π°ΡΠ° Ρ
ΠΈΡΡΡΠ³ΠΈΡ Π½Π°Π²Π»ΠΈΠ·Π°Ρ ΠΈΠ½ΠΎΠ²Π°ΡΠΈΠ²Π½ΠΈ ΠΌΠ΅ΡΠΎΠ΄ΠΈ Π·Π° ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠ²Π½ΠΎ Π»Π΅ΡΠ΅Π½ΠΈΠ΅. ΠΠ΄ΠΈΠ½ ΠΎΡ ΡΠ΅Π·ΠΈ ΠΌΠ΅ΡΠΎΠ΄ΠΈ, ΠΊΠΎΠΉΡΠΎ ΠΏΡΠΎΠ΄ΡΠ»ΠΆΠ°Π²Π° ΠΈ Π΄Π½Π΅Ρ Π΄Π° Π±ΡΠ΄Π΅ ΠΎΠ±Π΅ΠΊΡ Π½Π° Π·Π°Π΄ΡΠ»Π±ΠΎΡΠ΅Π½ΠΈ Π½Π°ΡΡΠ½ΠΈ ΠΈΠ·ΡΠ»Π΅Π΄Π²Π°Π½ΠΈΡ Π΅ Π»Π°ΠΏΠ°ΡΠΎΡΠΊΠΎΠΏΡΠΊΠ°ΡΠ° ΠΌΠΈΠΎΠΌΠ΅ΠΊΡΠΎΠΌΠΈΡ. ΠΡ 1990 Π³ Π»Π°ΠΏΠ°ΡΠΎΡΠΊΠΎΠΏΡΠΊΠ°ΡΠ° ΠΌΠΈΠΎΠΌΠ΅ΠΊΡΠΎΠΌΠΈΡ ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»ΡΠ²Π° Π°Π»ΡΠ΅ΡΠ½Π°ΡΠΈΠ²Π° Π½Π° Π»Π°ΠΏΠ°ΡΠΎΡΠΎΠΌΠΈΡΡΠ° Π² ΡΠ»ΡΡΠ°ΠΉ Π½Π° Π½ΡΠΆΠ΄Π° ΠΎΡ ΠΎΡΡΡΡΠ°Π½ΡΠ²Π°Π½Π΅ Π½Π° ΡΡΠ±ΡΠ΅ΡΠΎΠ·Π½ΠΈ ΠΈ ΠΈΠ½ΡΡΠ°ΠΌΡΡΠ°Π»Π½ΠΈ ΠΌΠΈΠΎΠΌΠ½ΠΈ Π²ΡΠ·Π»ΠΈ. Π Π»ΠΈΡΠ΅ΡΠ°ΡΡΡΠ°ΡΠ° ΡΠ° ΠΎΠΏΠΈΡΠ°Π½ΠΈ ΡΠ°Π·Π½ΠΎΠΎΠ±ΡΠ°Π·Π½ΠΈ ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠ²Π½ΠΈ ΡΠ΅Ρ
Π½ΠΈΠΊΠΈ Π·Π° Π»Π°ΠΏΠ°ΡΠΎΡΠΊΠΎΠΏΡΠΊΠ° ΠΌΠΈΠΎΠΌΠ΅ΠΊΡΠΎΠΌΠΈΡ. Π’Π΅ ΡΠ΅ ΡΠ°Π·Π»ΠΈΡΠ°Π²Π°Ρ ΠΊΠ°ΠΊΡΠΎ ΠΏΠΎ ΠΎΡΠ½ΠΎΡΠ΅Π½ΠΈΠ΅ Π½Π° ΠΈΠ·ΠΏΠΎΠ»Π·Π²Π°Π½Π°ΡΠ° Π°ΠΏΠ°ΡΠ°ΡΡΡΠ° ΠΈ ΠΈΠ½ΡΡΡΡΠΌΠ΅Π½ΡΠ°ΡΠΈΡΠΌ, ΡΠ°ΠΊΠ° ΠΈ ΠΏΠΎ ΠΎΡΠ½ΠΎΡΠ΅Π½ΠΈΠ΅ Π½Π° Π΄ΠΎΡΡΡΠΏΠ° ΠΈ ΠΎΡΠ΄Π΅Π»Π½ΠΈΡΠ΅ Π΅ΡΠ°ΠΏΠΈ Π½Π° ΠΎΠΏΠ΅ΡΠ°ΡΠΈΡ. ΠΠ° Π΄Π° ΡΠ΅ ΠΈΠ·Π²ΡΡΡΠ°Ρ ΡΠΎΡΠ½ΠΈ Π½Π°ΡΡΠ½ΠΈ ΡΡΠ°Π²Π½ΠΈΡΠ΅Π»Π½ΠΈ Π°Π½Π°Π»ΠΈΠ·ΠΈ Π΅ Π½ΡΠΆΠ½ΠΎ Π²ΡΠ²Π΅ΠΆΠ΄Π°Π½Π΅ Π½Π° ΡΡΠ°Π½Π΄Π°ΡΡΠΈΠ·ΠΈΡΠ°Π½ ΠΌΠ΅ΡΠΎΠ΄ Π·Π° Π»Π°ΠΏΠ°ΡΠΎΡΠΊΠΎΠΏΡΠΊΠ° ΠΌΠΈΠΎΠΌΠ΅ΠΊΡΠΎΠΌΠΈΡ. Π Π½Π°ΡΡΠ½Π°ΡΠ° Π»ΠΈΡΠ΅ΡΠ°ΡΡΡΠ° Π΄Π°Π½Π½ΠΈΡΠ΅ Π·Π° ΠΈΠ½ΡΡΠ°- ΠΈ ΠΏΠΎΡΡΠΎΠΏΠ΅ΡΠ°ΡΠΈΠ²Π½ΠΈΡΠ΅ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΠΈ ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠ²Π½ΠΎ Π²ΡΠ΅ΠΌΠ΅, Π±ΠΎΠ»Π½ΠΈΡΠ΅Π½ ΠΏΡΠ΅ΡΡΠΎΠΉ ΠΈ ΠΊΡΡΠ²ΠΎΠ·Π°Π³ΡΠ±Π° ΡΠ° ΠΏΡΠΎΡΠΈΠ²ΠΎΡΠ΅ΡΠΈΠ²ΠΈ. Π‘ΡΠ°Π²Π½ΠΈΡΠ΅Π»Π½ΠΎ ΠΌΠ°Π»ΠΊΠΎ ΡΠ΅ ΠΎΠ±ΡΡΡΠ° Π²Π½ΠΈΠΌΠ°Π½ΠΈΠ΅ Π½Π° ΡΠ°ΠΊΡΠΎΡΠΈΡΠ΅, ΠΎΠΊΠ°Π·Π²Π°ΡΠΈ Π²Π»ΠΈΡΠ½ΠΈΠ΅ Π²ΡΡΡ
Ρ ΠΏΡΠΎΠ΄ΡΠ»ΠΆΠΈΡΠ΅Π»Π½ΠΎΡΡΡΠ° Π½Π° ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠ²Π½Π°ΡΠ° ΠΈΠ½ΡΠ΅ΡΠ²Π΅Π½ΡΠΈΡ. ΠΡΠΎΡΠΈΠ²ΠΎΡΠ΅ΡΠΈΠ²ΠΈ ΡΠ° ΡΠ΅Π·ΡΠ»ΡΠ°ΡΠΈΡΠ΅ Π·Π° ΡΠ΅ΡΡΠΎΡΠ°ΡΠ° Π½Π° ΡΡΠ»ΠΎΠΆΠ½Π΅Π½ΠΈΡΡΠ° ΠΏΡΠΈ Π»Π°ΠΏΠ°ΡΠΎΡΠΊΠΎΠΏΡΠΊΠ°ΡΠ° ΠΌΠΈΠΎΠΌΠ΅ΠΊΡΠΎΠΌΠΈΡ ΠΏΠΎΡΠ°Π΄ΠΈ ΡΠ°Π·Π»ΠΈΡΠ½ΠΈΡΠ΅ ΠΏΡΠΎΡΡΠ²Π°Π½ΠΈΡ (ΡΠ΅ΡΡΠΎΡΠΏΠ΅ΠΊΡΠΈΠ²Π½ΠΈ, ΠΏΡΠΎΡΠΏΠ΅ΠΊΡΠΈΠ²Π½ΠΈ. Π½Π΅ΡΠ°Π½Π΄ΠΎΠΌΠΈΠ·ΠΈΡΠ°Π½ΠΈ, ΡΠ°Π½Π΄ΠΎΠΌΠΈΠ·ΠΈΡΠ°Π½ΠΈ, ΠΌΠ΅ΡΠ° - Π°Π½Π°Π»ΠΈΠ·ΠΈ). ΠΠ·Π²ΡΡΡΠ΅Π½Π° ΠΎΡ Π΄ΠΎΠ±ΡΠ΅ ΠΎΠ±ΡΡΠ΅Π½ΠΈ ΡΠΏΠ΅ΡΠΈΠ°Π»ΠΈΡΡΠΈ ΡΠΈΡΠΊΡΡ ΠΎΡ ΠΏΠ΅ΡΠΈΠΎΠΏΠ΅ΡΠ°ΡΠΈΠ²Π½ΠΈ ΡΡΠ»ΠΎΠΆΠ½Π΅Π½ΠΈΡ Π½Π΅ Π½Π°Π΄Π²ΠΈΡΠ°Π²Π° ΡΡΠ°Π½Π΄Π°ΡΡΠ½ΠΈΡΠ΅ ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠ²Π½ΠΈ ΡΠ΅Ρ
Π½ΠΈΠΊΠΈ
Serum anti-Ξ±-crystallin antibodies in women with endocrine disorders
There is a distinct group among the patients with unexplained infertility who are found to have enhanced humoral immune response. Recent studies focus on the expression of stress proteins being an important factor in the stages of gametogenesis, fertilization, implantation, early embryonic development and pregnancy. Increased expression of stress proteins and immune response against them was found in tissues exposed to stress. There is not enough data linking infertility to expression and immunity of Ξ±-crystallins in patients with endocrine diseases. The aim of this work was to study anti-Ξ±-crystallin antibodies in patients with polycystic ovary syndrome (PCOS), Gravesβ disease, autoimmune thyroiditis, diabetes mellitus and obesity. Sera samples from 169 women with endocrine disorders (PCOS (n = 68); Gravesβ disease (n = 26); autoimmune thyroiditis (n = 32); diabetes mellitus (n = 10); and obesity (n = 33)) were tested by ELISA. The statistical analysis was performed using SPSS program. The concentration of anti-Ξ±-crystallin antibodies is significantly elevated in the PCOS group compared to the control group (p = 0.021). The frequency of positive sera in the same group of patients is significantly higher compared to the control group (p = 0.029). In all other groups, no statistically significant elevation was observed. Elevated concentrations of anti-Ξ±-crystallin antibodies found in patients with PCOS suggest that the increased production of anti-Ξ±-crystallin antibodies in women with PCOS is most probably caused by failure of the immune tolerance and the induction of immune response. This is most likely due to an increased expression of this stress protein as a result of oxidative stress and chronic inflammation