175 research outputs found
ΠΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠΈ ΡΡΠ½ΠΊΡΠΈΠΎΠ½Π°Π»ΡΠ½ΠΎΠ³ΠΎ ΡΠΎΡΡΠΎΡΠ½ΠΈΡ ΡΠ΅ΡΠ΄ΡΠ° ΠΏΡΠΈ ΠΎΡΡΡΠΎΠΉ Π³Π΅ΠΌΠΎΠ΄ΠΈΠ½Π°ΠΌΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΏΠ΅ΡΠ΅Π³ΡΡΠ·ΠΊΠ΅ Π»Π΅Π²ΠΎΠ³ΠΎ ΠΆΠ΅Π»ΡΠ΄ΠΎΡΠΊΠ° Π² ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ΅
On animal model of an acute hemodynamic overload of the left ventricle (LV) caused by the artificial aortic stenosis, some characteristics of left and right ventricular contractive activity and diastolic function were studied. It was found that a sudden increase in afterload leads to a significant reduction of contractive activity and potential working capacity of both ventricles. LV also suffers from diastolic dysfunction.Π ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ΅ Π½Π° ΠΌΠΎΠ΄Π΅Π»ΠΈ ΠΎΡΡΡΠΎΠΉ Π³Π΅ΠΌΠΎΠ΄ΠΈΠ½Π°ΠΌΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΏΠ΅ΡΠ΅Π³ΡΡΠ·ΠΊΠΈ Π»Π΅Π²ΠΎΠ³ΠΎ ΠΆΠ΅Π»ΡΠ΄ΠΎΡΠΊΠ° ΡΠ΅ΡΠ΄ΡΠ°, Π²ΡΠ·Π²Π°Π½Π½ΠΎΠΉ ΠΈΡΠΊΡΡΡΡΠ²Π΅Π½Π½ΡΠΌ ΡΡΠ΅Π½ΠΎΠ·ΠΎΠΌ Π²ΠΎΡΡ
ΠΎΠ΄ΡΡΠ΅ΠΉ Π°ΠΎΡΡΡ, ΠΈΠ·ΡΡΠ°Π»ΠΈ ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠΈ ΡΠΎΠΊΡΠ°ΡΠΈΡΠ΅Π»ΡΠ½ΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΠΈ Π΄ΠΈΠ°ΡΡΠΎΠ»ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΡΠ½ΠΊΡΠΈΠΈ Π»Π΅Π²ΠΎΠ³ΠΎ ΠΈ ΠΏΡΠ°Π²ΠΎΠ³ΠΎ ΠΆΠ΅Π»ΡΠ΄ΠΎΡΠΊΠΎΠ². Π£ΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΎ, ΡΡΠΎ Π²Π½Π΅Π·Π°ΠΏΠ½ΠΎΠ΅ ΡΠ²Π΅Π»ΠΈΡΠ΅Π½ΠΈΠ΅ ΠΏΠΎΡΡΠ½Π°Π³ΡΡΠ·ΠΊΠΈ ΠΏΡΠΈΠ²ΠΎΠ΄ΠΈΡ ΠΊ Π·Π½Π°ΡΠΈΡΠ΅Π»ΡΠ½ΠΎΠΌΡ ΡΠ½ΠΈΠΆΠ΅Π½ΠΈΡ ΡΠΎΠΊΡΠ°ΡΠΈΡΠ΅Π»ΡΠ½ΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΠΈ ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°Π»ΡΠ½ΠΎΠΉ ΡΠ°Π±ΠΎΡΠΎΡΠΏΠΎΡΠΎΠ±Π½ΠΎΡΡΠΈ ΠΎΠ±ΠΎΠΈΡ
ΠΆΠ΅Π»ΡΠ΄ΠΎΡΠΊΠΎΠ². Π Π»Π΅Π²ΠΎΠΌ ΠΆΠ΅Π»ΡΠ΄ΠΎΡΠΊΠ΅ ΡΠ°ΠΊΠΆΠ΅ ΡΠ°Π·Π²ΠΈΠ²Π°Π΅ΡΡΡ Π΄ΠΈΠ°ΡΡΠΎΠ»ΠΈΡΠ΅ΡΠΊΠ°Ρ Π΄ΠΈΡΡΡΠ½ΠΊΡΠΈΡ
ΠΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΠΊΠ°ΡΠΏΠ°Π·Ρ 3 ΠΈ ΠΊΠ°ΡΠΏΠ°Π·Ρ 8 Π² ΠΊΠ»Π΅ΡΠΊΠ°Ρ ΠΌΠΈΠΎΠΊΠ°ΡΠ΄Π° ΠΏΡΠ°Π²ΠΎΠ³ΠΎ ΠΆΠ΅Π»ΡΠ΄ΠΎΡΠΊΠ° ΠΏΡΠΈ ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΠΎΠΉ Π°ΡΡΠ΅ΡΠΈΠ°Π»ΡΠ½ΠΎΠΉ Π³ΠΈΠΏΠ΅ΡΡΠ΅Π½Π·ΠΈΠΈ
Caspase-3 and caspase-8 activity in right ventricular myocardial cells of rabbits with experimental arterial hypertension (AH) was investigated. Caspase-3 activity significantly increased at 2 and 4 weeks after modeling of AH. Obtained data demonstrated increased apoptosis in right ventricular myocardial cells in experimental arterial hypertension. Absence of significant increasing of caspase-8 activity indicates the predominance of intrinsic apoptogenic signals.ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½Π° Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΠΊΠ°ΡΠΏΠ°Π·Ρ 3 ΠΈ ΠΊΠ°ΡΠΏΠ°Π·Ρ 8 Π² ΠΊΠ»Π΅ΡΠΊΠ°Ρ
ΠΌΠΈΠΎΠΊΠ°ΡΠ΄Π° ΠΏΡΠ°Π²ΠΎΠ³ΠΎ ΠΆΠ΅Π»ΡΠ΄ΠΎΡΠΊΠ° ΡΠ΅ΡΠ΄ΡΠ° ΠΊΡΠΎΠ»ΠΈΠΊΠΎΠ² Ρ ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΠΎΠΉ Π°ΡΡΠ΅ΡΠΈΠ°Π»ΡΠ½ΠΎΠΉ Π³ΠΈΠΏΠ΅ΡΡΠ΅Π½Π·ΠΈΠ΅ΠΉ (ΠΠ). ΠΠ±Π½Π°ΡΡΠΆΠ΅Π½ΠΎ Π΄ΠΎΡΡΠΎΠ²Π΅ΡΠ½ΠΎΠ΅ ΠΏΠΎΠ²ΡΡΠ΅Π½ΠΈΠ΅ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΠΊΠ°ΡΠΏΠ°Π·Ρ 3 ΡΠ΅ΡΠ΅Π· 2 ΠΈ 4 Π½Π΅Π΄Π΅Π»ΠΈ ΠΏΠΎΡΠ»Π΅ ΠΌΠΎΠ΄Π΅Π»ΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΠΠ. ΠΠΎΠ»ΡΡΠ΅Π½Π½ΡΠ΅ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ ΡΠ²ΠΈΠ΄Π΅ΡΠ΅Π»ΡΡΡΠ²ΡΡΡ ΠΎΠ± ΡΡΠΈΠ»Π΅Π½ΠΈΠΈ Π°ΠΏΠΎΠΏΡΠΎΡΠΈΡΠ΅ΡΠΊΠΎΠΉ Π³ΠΈΠ±Π΅Π»ΠΈ ΠΊΠ»Π΅ΡΠΎΠΊ ΠΌΠΈΠΎΠΊΠ°ΡΠ΄Π° ΠΏΡΠ°Π²ΠΎΠ³ΠΎ ΠΆΠ΅Π»ΡΠ΄ΠΎΡΠΊΠ° ΠΏΡΠΈ ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΠΎΠΉ Π°ΡΡΠ΅ΡΠΈΠ°Π»ΡΠ½ΠΎΠΉ Π³ΠΈΠΏΠ΅ΡΡΠ΅Π½Π·ΠΈΠΈ. Π‘ΡΠ°ΡΠΈΡΡΠΈΡΠ΅ΡΠΊΠΈ Π½Π΅Π·Π½Π°ΡΠΈΠΌΠΎΠ΅ ΠΏΠΎΠ²ΡΡΠ΅Π½ΠΈΠ΅ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΠΊΠ°ΡΠΏΠ°Π·Ρ 8 ΡΠΊΠ°Π·ΡΠ²Π°Π΅Ρ Π½Π° ΠΏΡΠ΅ΠΎΠ±Π»Π°Π΄Π°Π½ΠΈΠ΅ Π²Π½ΡΡΡΠΈΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠ³ΠΎ Π°ΠΏΠΎΠΏΡΠΎΠ³Π΅Π½Π½ΠΎΠ³ΠΎ ΡΠΈΠ³Π½Π°Π»Π°
ΠΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠΈ ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΡ ΡΠΎΠΊΡΠ°ΡΠΈΡΠ΅Π»ΡΠ½ΠΎΠΉ ΡΡΠ½ΠΊΡΠΈΠΈ ΡΠ΅ΡΠ΄ΡΠ° ΠΏΡΠΈ ΡΠΎΡΠ΅ΡΠ°Π½ΠΈΠΈ ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΠΎΠΉ Π°ΡΡΠ΅ΡΠΈΠ°Π»ΡΠ½ΠΎΠΉ Π³ΠΈΠΏΠ΅ΡΡΠ΅Π½Π·ΠΈΠΈ Ρ ΠΎΡΡΡΠΎΠΉ ΠΊΠΎΡΠΎΠ½Π°ΡΠ½ΠΎΠΉ Π½Π΅Π΄ΠΎΡΡΠ°ΡΠΎΡΠ½ΠΎΡΡΡΡ Π½Π° ΡΠΎΠ½Π΅ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ Π°Π½ΡΠ°Π³ΠΎΠ½ΠΈΡΡΠΎΠ² ΠΊΠ°Π»ΡΡΠΈΡ
The functional state of cardiovascular system was studied in a rabbit model of acute coronary insufficiency and arterial hypertension treated with Calcium channel blocker verapamil. It was established that the potential working capacity of cardiac left ventricle decreases more significantly in case of 6-week experimental model of arterial hypertension in comparison with acute coronary insufficiency, which affect more considerably the working capacity of the right ventricle. We also assume that the favorable effect of verapamil on the parameters of heart contractile function in case of arterial hypertension with consequent development of acute coronary insufficiency is linked to the preservation of right ventricle's functional reserve.ΠΠ·ΡΡΠ°Π»ΠΈ ΡΡΠ½ΠΊΡΠΈΠΎΠ½Π°Π»ΡΠ½ΠΎΠ΅ ΡΠΎΡΡΠΎΡΠ½ΠΈΠ΅ ΡΠ΅ΡΠ΄Π΅ΡΠ½ΠΎ-ΡΠΎΡΡΠ΄ΠΈΡΡΠΎΠΉ ΡΠΈΡΡΠ΅ΠΌΡ ΠΊΡΠΎΠ»ΠΈΠΊΠΎΠ² ΠΏΠΎΡΠ»Π΅ ΠΌΠΎΠ΄Π΅Π»ΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΠΎΡΡΡΠΎΠΉ ΠΊΠΎΡΠΎΠ½Π°ΡΠ½ΠΎΠΉ Π½Π΅Π΄ΠΎΡΡΠ°ΡΠΎΡΠ½ΠΎΡΡΠΈ ΠΈ Π°ΡΡΠ΅ΡΠΈΠ°Π»ΡΠ½ΠΎΠΉ Π³ΠΈΠΏΠ΅ΡΡΠ΅Π½Π·ΠΈΠΈ ΠΈ Π»Π΅ΡΠ΅Π½ΠΈΡ Π΅Π΅ Π²Π΅ΡΠ°ΠΏΠ°ΠΌΠΈΠ»ΠΎΠΌ. ΠΡΠ»ΠΎ ΡΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΎ, ΡΡΠΎ ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°Π»ΡΠ½Π°Ρ ΡΠ°Π±ΠΎΡΠΎΡΠΏΠΎΡΠΎΠ±Π½ΠΎΡΡΡ Π»Π΅Π²ΠΎΠ³ΠΎ ΠΆΠ΅Π»ΡΠ΄ΠΎΡΠΊΠ° ΡΠ΅ΡΠ΄ΡΠ° ΡΠ½ΠΈΠΆΠ°Π΅ΡΡΡ Π±ΠΎΠ»Π΅Π΅ Π·Π½Π°ΡΠΈΡΠ΅Π»ΡΠ½ΠΎ ΠΏΡΠΈ ΡΠ°Π·Π²ΠΈΡΠΈΠΈ 6-Π½Π΅Π΄Π΅Π»ΡΠ½ΠΎΠΉ ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΠΎΠΉ Π°ΡΡΠ΅ΡΠΈΠ°Π»ΡΠ½ΠΎΠΉ Π³ΠΈΠΏΠ΅ΡΡΠ΅Π½Π·ΠΈΠΈ ΠΏΠΎ ΡΡΠ°Π²Π½Π΅Π½ΠΈΡ Ρ ΠΎΡΡΡΠΎΠΉ ΠΊΠΎΡΠΎΠ½Π°ΡΠ½ΠΎΠΉ Π½Π΅Π΄ΠΎΡΡΠ°ΡΠΎΡΠ½ΠΎΡΡΡΡ, ΠΊΠΎΡΠΎΡΠ°Ρ Π²Π»ΠΈΡΠ΅Ρ Π±ΠΎΠ»Π΅Π΅ Π²ΡΡΠ°ΠΆΠ΅Π½ΠΎ Π½Π° ΡΠ°Π±ΠΎΡΠΎΡΠΏΠΎΡΠΎΠ±Π½ΠΎΡΡΡ ΠΏΡΠ°Π²ΠΎΠ³ΠΎ ΠΆΠ΅Π»ΡΠ΄ΠΎΡΠΊΠ°. Π’Π°ΠΊΠΆΠ΅ ΠΌΠΎΠΆΠ½ΠΎ ΠΏΡΠ΅Π΄ΠΏΠΎΠ»ΠΎΠΆΠΈΡΡ, ΡΡΠΎ ΠΏΠΎΠ»ΠΎΠΆΠΈΡΠ΅Π»ΡΠ½ΠΎΠ΅ Π²Π»ΠΈΡΠ½ΠΈΠ΅ Π²Π΅ΡΠ°ΠΏΠ°ΠΌΠΈΠ»Π° Π½Π° ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΠΈ ΡΠΎΠΊΡΠ°ΡΠΈΡΠ΅Π»ΡΠ½ΠΎΠΉ ΡΡΠ½ΠΊΡΠΈΠΈ ΡΠ΅ΡΠ΄ΡΠ° ΠΏΡΠΈ Π°ΡΡΠ΅ΡΠΈΠ°Π»ΡΠ½ΠΎΠΉ Π³ΠΈΠΏΠ΅ΡΡΠ΅Π½Π·ΠΈΠΈ ΠΈ ΠΏΠΎΡΠ»Π΅Π΄ΡΡΡΠΈΠΌ ΡΠ°Π·Π²ΠΈΡΠΈΠ΅ΠΌ ΠΎΡΡΡΠΎΠΉ ΠΊΠΎΡΠΎΠ½Π°ΡΠ½ΠΎΠΉ Π½Π΅Π΄ΠΎΡΡΠ°ΡΠΎΡΠ½ΠΎΡΡΠΈ ΡΠ²ΡΠ·Π°Π½Π½ΠΎ Ρ ΡΠΎΡ
ΡΠ°Π½Π΅Π½ΠΈΠ΅ΠΌ Π½Π° ΡΠΎΠ½Π΅ ΠΏΡΠΈΠ΅ΠΌΠ° Π²Π΅ΡΠ°ΠΏΠ°ΠΌΠΈΠ»Π° ΡΡΠ½ΠΊΡΠΈΠΎΠ½Π°Π»ΡΠ½ΠΎΠ³ΠΎ ΡΠ΅Π·Π΅ΡΠ²Π° ΠΏΡΠ°Π²ΠΎΠ³ΠΎ ΠΆΠ΅Π»ΡΠ΄ΠΎΡΠΊΠ°
Π ΡΠΈΠΏΠΎΠ²ΡΡ ΡΠ΅Π°ΠΊΡΠΈΡΡ ΠΏΠΎΠ²ΡΠ΅ΠΆΠ΄Π΅Π½Π½ΠΎΠ³ΠΎ ΡΠ΅ΡΠ΄ΡΠ°
On the basis of experimental research we described nine typical (nonspecific) responses of the damaged heart which are initially protective and adaptive but are able to have a pathogenetic character under some certain conditions. These typical responses are as follows: shortening of the effective refractory period of the myocardium, cardiomyocyte mitochondrion swelling, activation of lysosomal apparatus, initial intensification of lipolysis, hypertrophy of cardiac muscle, formation of collagen muffs around blood vessels due to intoxication, functional deafferentation of the heart, changes in the intensity of cardiomyocyte apoptosis, rearrangement of cardiac chronostructure. The represented results can be used as a basis to elaborate some new effective methods of prophilaxis and treatment of heart diseases caused by different etiological factors.ΠΠ° ΠΎΡΠ½ΠΎΠ²Π°Π½ΠΈΠΈ ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΡΡ
ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ Π²ΡΠ΄Π΅Π»Π΅Π½ΠΎ Π΄Π΅Π²ΡΡΡ ΡΠΈΠΏΠΎΠ²ΡΡ
(Π½Π΅ΡΠΏΠ΅ΡΠΈΡΠΈΡΠ΅ΡΠΊΠΈΡ
) ΡΠ΅Π°ΠΊΡΠΈΠΉ ΠΏΠΎΠ²ΡΠ΅ΠΆΠ΄Π΅Π½Π½ΠΎΠ³ΠΎ ΡΠ΅ΡΠ΄ΡΠ°, ΠΏΠ΅ΡΠ²ΠΈΡΠ½ΠΎ ΡΠ²Π»ΡΡΡΠΈΡ
ΡΡ Π·Π°ΡΠΈΡΠ½ΠΎ-ΠΏΡΠΈΡΠΏΠΎΡΠΎΠ±ΠΈΡΠ΅Π»ΡΠ½ΡΠΌΠΈ, Π½ΠΎ ΠΌΠΎΠ³ΡΡΠΈΡ
ΠΏΡΠΈ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½Π½ΡΡ
ΠΎΠ±ΡΡΠΎΡΡΠ΅Π»ΡΡΡΠ²Π°Ρ
ΠΈΠ³ΡΠ°ΡΡ ΠΈ ΠΏΠ°ΡΠΎΠ³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΡΡ ΡΠΎΠ»Ρ: ΡΠΊΠΎΡΠΎΡΠ΅Π½ΠΈΠ΅ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΠ³ΠΎ ΡΠ΅ΡΡΠ°ΠΊΡΠ΅ΡΠ½ΠΎΠ³ΠΎ ΠΏΠ΅ΡΠΈΠΎΠ΄Π° ΠΌΠΈΠΎΠΊΠ°ΡΠ΄Π°, Π½Π°Π±ΡΡ
Π°Π½ΠΈΠ΅ ΠΌΠΈΡΠΎΡ
ΠΎΠ½Π΄ΡΠΈΠΉ ΠΊΠ°ΡΠ΄ΠΈΠΎΠΌΠΈΠΎΡΠΈΡΠ°, Π°ΠΊΡΠΈΠ²Π°ΡΠΈΡ Π»ΠΈΠ·ΠΎΡΠΎΠΌΠ½ΠΎΠ³ΠΎ Π°ΠΏΠΏΠ°ΡΠ°ΡΠ°, ΠΈΠ½ΠΈΡΠΈΠ°Π»ΡΠ½ΠΎΠ΅ ΡΡΠΈΠ»Π΅Π½ΠΈΠ΅ Π»ΠΈΠΏΠΎΠ»ΠΈΠ·Π°, Π³ΠΈΠΏΠ΅ΡΡΡΠΎΡΠΈΡ ΡΠ΅ΡΠ΄Π΅ΡΠ½ΠΎΠΉ ΠΌΡΡΡΡ, ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΠ΅ Π²ΠΎΠΊΡΡΠ³ ΠΌΠΈΠΎΠΊΠ°ΡΠ΄ΠΈΠ°Π»ΡΠ½ΡΡ
ΡΠΎΡΡΠ΄ΠΎΠ² ΠΊΠΎΠ»Π»Π°Π³Π΅Π½ΠΎΠ²ΡΡ
ΠΌΡΡΡ ΠΏΡΠΈ ΠΈΠ½ΡΠΎΠΊΡΠΈΠΊΠ°ΡΠΈΡΡ
, ΡΡΠ½ΠΊΡΠΈΠΎΠ½Π°Π»ΡΠ½Π°Ρ Π΄Π΅Π°ΡΡΠ΅ΡΠ΅Π½ΡΠ°ΡΠΈΡ ΡΠ΅ΡΠ΄ΡΠ°, ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ ΠΈΠ½ΡΠ΅Π½ΡΠΈΠ²Π½ΠΎΡΡΠΈ Π°ΠΏΠΎΠΏΡΠΎΠ·Π° ΠΊΠ°ΡΠ΄ΠΈΠΎΠΌΠΈΠΎΡΠΈΡΠΎΠ², ΠΏΠ΅ΡΠ΅ΡΡΡΠΎΠΉΠΊΠ° Ρ
ΡΠΎΠ½ΠΎΡΡΡΡΠΊΡΡΡΡ ΡΠ΅ΡΠ΄ΡΠ°. ΠΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½Π½ΡΠ΅ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ Π΄Π°ΡΡ ΠΎΡΠ½ΠΎΠ²Π°Π½ΠΈΡ Π΄Π»Ρ ΡΠ°Π·ΡΠ°Π±ΠΎΡΠΊΠΈ Π½ΠΎΠ²ΡΡ
ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΡΡ
ΠΌΠ΅ΡΠΎΠ΄ΠΎΠ² ΠΏΡΠΎΡΠΈΠ»Π°ΠΊΡΠΈΠΊΠΈ ΠΈ Π»Π΅ΡΠ΅Π½ΠΈΡ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΉ ΡΠ΅ΡΠ΄ΡΠ° ΡΠ°Π·Π»ΠΈΡΠ½ΠΎΠΉ ΡΡΠΈΠΎΠ»ΠΎΠ³ΠΈΠΈ
Daytime Exposure to Blue Light Alters Cardiovascular Circadian Rhythms, Electrolyte Excretion and Melatonin Production
Artificial light is characterized by certain features of its impact on the body in terms of its spectral distribution of power, duration of exposure and intensity. Short waves, perceived as blue light, are the strongest synchronizing agent for the circadian system. In the present work, we investigated the features of the circadian rhythms of blood pressure (BP), heart rate (HR), the excretion of electrolytes and the secretion of melatonin in normotensive (WistarβKyoto) and hypertensive (SHR) rats under the action of monochromatic blue light in the daytime period. It was found that the exposure of WistarβKyoto rats to monochromatic blue light was accompanied by a significant decrease in nighttime and 24 h systolic BP. The most remarkable changes are characteristic of the HR in SHR rats under monochromatic light. A significant decrease in HR in each time period was found, but the predominance of nighttime over daytime values remained in SHR animals. There was also a significant increase in the mesor of the HR in SHR rats. Additionally, the amplitude of diastolic BP and HR, as well as the range of oscillations in HR, were significantly increased compared with the standard light pattern. In contrast to SHR rats, the regulation of the circadian rhythms in WistarβKyoto rats was more flexible and presented more changes, which may be aimed at the adaptation of the body to environmental conditions. For WistarβKyoto rats, an increase in the level of excreted electrolytes was observed under the action of monochromatic light, but no similar changes were found in SHR rats. For WistarβKyoto rats, a significant decrease in the urine concentration of aMT6s in the daytime and nighttime periods is characteristic, which results in the loss of the circadian rhythm. In SHR rats, there was a significant decrease in the nighttime content of aMT6s in the urine, while the daytime concentration, on the contrary, increased. The obtained data demonstrate that prolonged exposure to monochromatic blue light in the daytime period affects the circadian structure of the rhythms of the cardiovascular system, the rhythm of electrolyte excretion and the production of epiphyseal melatonin in wild-type and hypertensive animals. In SHR rats, the rhythms of BP and HR exhibit a more rigid pattern
Specific function and morphology of the right ventricle of the heart during ischemic injury of the left ventricle
Focal ischemia of the left ventricular myocardium was modeled by surgical ligation of the descending branch of the left coronary artery at the junction of the lower and middle thirds of this artery in anesthetized rabbits. Contractility and morphological characteristics of the right ventricular myocardium were evaluated 24, 72, and 120 h after treatment. Significant morphofunctional changes in the right ventricle manifested in the development of severe extracellular edema and increase in the area of damaged and destroyed myofibrils. However, the actual and maximum intraventricular pressure remained unchanged under these conditions. The degree of cardiomyocyte apoptosis increased on day 1, but returned to normal in the follow-up period. Our study demonstrated high sensitivity of the right ventricle to left ventricular dysfunction and early activation of compensatory mechanisms. Β© Springer Science+Business Media, Inc. 2008
Induction of caspase cascade as a nonspecific response to myocardial damage
In three experimental series, acute hemodynamic overload of the left ventricle, focal ischemia of the left ventricle, and diphtheritic intoxication were modeled in rabbits. On days 1, 3, and 5 of the experiments, activity of myocardial caspase-3 and caspase-8 were measured separately in the left and right ventricles. In the left ventricle, caspase-3 activity increased in all 3 modeled pathological processes, while in the right ventricle this parameter increased during acute overload and ischemic injury to the left ventricle. Caspase-8 activity increased only in the left ventricle during its hemodynamic overload and remained unchanged in other cases. It was concluded that induction of the caspase cascade can be considered as a nonspecific response to myocardial damage. In this case, specific mechanisms responsible for generation and transmission of apoptotic stimuli in cardiomyocytes have unique features. Β© 2011 Springer Science+Business Media, Inc
Induction of caspase cascade as a nonspecific response to myocardial damage
In three experimental series, acute hemodynamic overload of the left ventricle, focal ischemia of the left ventricle, and diphtheritic intoxication were modeled in rabbits. On days 1, 3, and 5 of the experiments, activity of myocardial caspase-3 and caspase-8 were measured separately in the left and right ventricles. In the left ventricle, caspase-3 activity increased in all 3 modeled pathological processes, while in the right ventricle this parameter increased during acute overload and ischemic injury to the left ventricle. Caspase-8 activity increased only in the left ventricle during its hemodynamic overload and remained unchanged in other cases. It was concluded that induction of the caspase cascade can be considered as a nonspecific response to myocardial damage. In this case, specific mechanisms responsible for generation and transmission of apoptotic stimuli in cardiomyocytes have unique features. Β© 2011 Springer Science+Business Media, Inc
Specific function and morphology of the right ventricle of the heart during ischemic injury of the left ventricle
Focal ischemia of the left ventricular myocardium was modeled by surgical ligation of the descending branch of the left coronary artery at the junction of the lower and middle thirds of this artery in anesthetized rabbits. Contractility and morphological characteristics of the right ventricular myocardium were evaluated 24, 72, and 120 h after treatment. Significant morphofunctional changes in the right ventricle manifested in the development of severe extracellular edema and increase in the area of damaged and destroyed myofibrils. However, the actual and maximum intraventricular pressure remained unchanged under these conditions. The degree of cardiomyocyte apoptosis increased on day 1, but returned to normal in the follow-up period. Our study demonstrated high sensitivity of the right ventricle to left ventricular dysfunction and early activation of compensatory mechanisms. Β© Springer Science+Business Media, Inc. 2008
Analysis of central blood pressure during diphtheria intoxication in rabbits
Diphtheria intoxication was induced in rabbits by a single intravenous injection of native diphtheria toxin in dose of 0.3 MLD/kg, preliminary titrated on guinea pigs. Significant decrease in diastolic and systolic blood pressure and in intraventricular pressure in the left ventricle was established to take place during intoxication. Pulse wave propagation time was prolonged, likely due to prolongation of pressure wave, while the reflection wave appeared at the same time. Reduction of central blood pressure was concluded to result from changes in biomechanical characteristics of the left ventricle, and not to be associated with changes in elastic properties of the arterial wall. Β© 2009 Springer Science+Business Media, Inc
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