Review of Peter Kitson and Debbie Lee, eds., Slavery, Abolition and Emancipation: Writings in the British Romantic Period.

Peter Kitson and Debbie Lee, eds., Slavery, Abolition and Emancipation: Writings in the British Romantic Period. London: Pickering and Chatto, 1999. 8 Volume Set: 3664 pp. ISBN 1851965130

Review of Ian Baucom, Specters of the Atlantic: Finance Capital, Slavery, and the Philosophy of History.

Ian Baucom, Specters of the Atlantic: Finance Capital, Slavery, and the Philosophy of History. Durham, NC: Duke University Press, 2005. 400 pp. ISBN 9780822335962

Ethereal Ethics

In response to the Blackburn and Rowley essay on the President's Council on Bioethics, several thought-provoking opinions on ethical challenges in biomedical research are expressed by prominent stakeholder

The enumeration of finite rings

Let $p$ be a fixed prime. We show that the number of isomorphism classes of finite rings of order $p^n$ is $p^\alpha$, where $\alpha=\frac{4}{27}n^3+O(n^{5/2})$. This result was stated (with a weaker error term) by Kruse and Price in 1969; a problem with their proof was pointed out by Knopfmacher in 1973. We also show that the number of isomorphism classes of finite commutative rings of order $p^n$ is $p^\beta$, where $\beta=\frac{2}{27}n^3+O(n^{5/2})$. This result was stated (again with a weaker error term) by Poonen in 2008, with a proof that relies on the problematic step in Kruse and Price's argument.Comment: 31 pages. Change of title, revised appendix, and various other small changes since previous versio

Activity of lymphostatin, a lymphocyte inhibitory virulence factor of pathogenic Escherichia coli, is dependent on a cysteine protease motif

Lymphostatin (LifA) is a 366 kDa protein expressed by attaching & effacing Escherichia coli. It plays an important role in intestinal colonisation and inhibits the mitogen- and antigen-stimulated proliferation of lymphocytes and the synthesis of proinflammatory cytokines. LifA exhibits N-terminal homology with the glycosyltransferase domain of large clostridial toxins (LCTs). A DTD motif within this region is required for lymphostatin activity and binding of the sugar donor uridine diphosphate N-acetylglucosamine. As with LCTs, LifA also contains a cysteine protease motif (C1480, H1581, D1596) that is widely conserved within the YopT-like superfamily of cysteine proteases. By analogy with LCTs, we hypothesised that the CHD motif may be required for intracellular processing of the protein to release the catalytic N-terminal domain after uptake and low pH-stimulated membrane insertion of LifA within endosomes. Here, we created and validated a C1480A substitution mutant in LifA from enteropathogenic E. coli strain E2348/69. The purified protein was structurally near-identical to the wild-type protein. In bovine T lymphocytes treated with wild-type LifA, a putative cleavage product of approximately 140 kDa was detected. Appearance of the putative cleavage product was inhibited in a concentration-dependent manner by bafilomycin A1 and chloroquine, which inhibit endosome acidification. The cleavage product was not observed in cells treated with the C1480A mutant of LifA. Lymphocyte inhibitory activity of the purified C1480A protein was significantly impaired. The data indicate that an intact cysteine protease motif is required for cleavage of lymphostatin and its activity against T cells

Comparative analysis of RANS and DDES methods for aerodynamic performance predictions for high performance vehicles at low ground clearances

Various assessments of RANS and Hybrid RANS-LES turbulence models have been conducted for automotive applications. However, their applicability for high performance vehicles which exhibit much more complex flow phenomena is not well studied yet. In this work, the predictive capabilities of RANS and DDES models are investigated through a comparative study on a high performance configuration of the DrivAer Fastback model at a low ground clearance in an open road computational domain. The results show much agreement in the general pressure distribution, except in areas of highly unsteady flow. Visualisation of the flow field depicts that the DDES simulation is able to capture a wider range of turbulent scales with a higher fidelity. Lastly, variation in the magnitude, distribution and decay of pressure losses in the wake are observed between both simulations. The presented results are used to illustrate the capabilities and limitations of these turbulence models for other academic or industrial users to make an informed decision on the turbulence model suited for their objectives

Effects of cornering conditions on the aerodynamic characteristics of a high-performance vehicle and its rear wing

This study investigates the aerodynamic behavior of a high-performance vehicle and the interaction with its rear wing in straight-line and steady-state cornering conditions. Analyses are performed with Reynolds-averaged Navier–Stokes based computational fluid dynamics simulations using a moving reference frame and overset mesh technique, validated against moving ground wind tunnel experiments. The results indicate a significant 20% decrease in downforce and 35% increase in drag compared to straight-line conditions at the smallest considered corner radius of 2.9 car-lengths. Downforce losses primarily stem from performance deficits on the underbody and rear wing, alongside elevated upper body lift. Drag penalties mainly result from additional pressure drag induced by a recirculation wake vortex generated behind the vehicle's inboard side. The vehicle's lateral pressure distribution is also affected, introducing a centripetal force that increases with smaller corner radii. Additionally, analyses of the rear wing reveal alternations of its aerodynamic characteristics in cornering, particularly impacting vortical flow and suction on the lower surface. Throughout the operating conditions, the rear wing's individual downforce contribution falls off beyond its stall angle. At higher angles of attack, the rear wing primarily generates downforce by pressurizing the vehicle's upper surfaces, but its interaction with the near-wake leads to a substantially increased pressure drag. Overall, these findings provide crucial insights into the intricate aerodynamic interactions of high-performance vehicles in diverse operating conditions as well as form an essential foundation for future research on static and active aerodynamic designs in the pursuit to optimize vehicle performance in dynamic driving conditions

Experimental and numerical investigation of the aerodynamic characteristics of high-performance vehicle configurations under yaw conditions

This study investigates the impact of yaw conditions on the aerodynamic performance and flow field of three high-performance vehicle model configurations by means of wind tunnel testing and unsteady Reynolds-Averaged Navier–Stokes-based computational fluid dynamics simulations. While yaw effects on automotive vehicles have been explored, the effects on far more complex flow fields of high-performance vehicles remain insufficiently researched. This paper reveals that yaw conditions have a significant negative influence both downforce and drag performance. Spoiler and rear wing devices enhance downforce but increase the vehicle's sensitivity to yaw. Furthermore, yaw conditions significantly alter vortex structures and local flow velocities, affecting downstream flow behavior. Surface pressure measurements on the slant confirm these findings and highlight notable yaw effects and upstream effects from spoiler and rear wing devices. Wake analyses through total pressure measurements show that yaw induces a substantial deviation from straight-line wake characteristics, which become dominated by an inboard rotating vehicle body vortex. Overall, this research enhances the understanding of the effects of yaw conditions on high-performance vehicle aerodynamics and provides valuable data for future vehicle aerodynamics research in real-world operating conditions