Software for web-based tic suppression training [version 2; referees: 3 approved]

Exposure and response prevention (ERP) is a first-line behavior therapy for obsessive-compulsive disorder and Tourette syndrome (TS). However, ERP for tic disorders requires intentional tic suppression, which for some patients is difficult even for brief periods. Additionally, practical access to behavior therapy is difficult for many patients, especially those in rural areas. The authors present a simple, working web platform (TicTrainer) that implements a strategy called reward-enhanced exposure and response prevention (RE–ERP). This strategy sacrifices most expert therapist components of ERP, focusing only on increasing the duration of time for which the user can suppress tics through automated differential reinforcement of tic-free periods (DRO). RE–ERP requires an external tic monitor, such as a parent, during training sessions. The user sees increasing digital rewards for longer and longer periods of successful tic suppression, similar to a video game score. TicTrainer is designed with security in mind, storing no personally identifiable health information, and has features to facilitate research, including optional masked comparison of tics during DRO vs. noncontingent reward conditions. A working instance of TicTrainer is available from https://tictrainer.com

How the credit channel works: differentiating the bank lending channel and the balance sheet channel

The credit channel of monetary policy transmission operates through changes in lending. To examine this channel, we explore how movements in the real federal funds rate affect bank lending. Using data on individual loans from the Survey of Terms of Bank Lending, we are able to differentiate two ways the credit channel can work: by affecting overall bank lending (the bank lending channel) and by affecting the allocation of loans (the balance sheet channel). We find evidence consistent with the operation of both internal credit channels. During periods of tight monetary policy, banks adjust their stock of loans by reducing the maturity of loan originations and they reallocate their short-term loan supply from small firms to large firms. These results are stronger for large banks than for small banks.Monetary policy ; Bank loans

Gas Gain Measurements from a Negative Ion TPC X-ray Polarimeter

Gas-based time projection chambers (TPCs) have been shown to be highly sensitive X-ray polarimeters having excellent quantum efficiency while at the same time achieving large modulation factors. To observe polarization of the prompt X-ray emission of a Gamma-ray burst (GRB), a large area detector is needed. Diffusion of the electron cloud in a standard TPC could be prohibitive to measuring good modulation when the drift distance is large. Therefore, we propose using a negative ion TPC (NITPC) with Nitromethane (CH3NO2) as the electron capture agent. The diffusion of negative ions is reduced over that of electrons due to the thermal coupling of the negative ions to the surrounding gas. This allows for larger area detectors as the drift distance can be increased without degrading polarimeter modulation. Negative ions also travel ~200 times slower than electrons, allowing the readout electronics to operate slower, resulting in a reduction of instrument power. To optimize the NITPC design, we have measured gas gain with SciEnergy gas electron multipliers (GEMs) in single and double GEM configurations. Each setup was tested with different gas combinations, concentrations and pressures: P10 700 Torr, Ne+CO2 700 Torr at varying concentrations of CO2 and Ne+CO2+CH3NO2 700 Torr. We report gain as a function of total voltage, measured from top to bottom of the GEM stack, and as a function of drift field strength for the gas concentrations listed above. Examples of photoelectron tracks at 5.9 keV are also presented.Comment: 6 pages, 6 figures, accepted for publication in IEEE Trans Nucl Sc

Some contemporary issues affecting the South African auditor : inaugural address delivered at Rhodes University

Inaugural address delivered at Rhodes University.Rhodes University Libraries (Digitisation

A benign, low Z electron capture agent for negative ion TPCs

We have identified nitromethane (CH$_3$NO$_2$) as an effective electron capture agent for negative ion TPCs (NITPCs). We present drift velocity and longitudinal diffusion measurements for negative ion gas mixtures using nitromethane as the capture agent. Not only is nitromethane substantially more benign than the only other identified capture agent, CS$_2$, but its low atomic number will enable the use of the NITPC as a photoelectric X{}-ray polarimeter in the 1{}-10 keV band

Classifying the secondary component of the binary star W Aquilae

AIMS: The object W Aql is an asymptotic giant branch (AGB) star with a faint companion. By determining more carefully the properties of the companion, we hope to better constrain the properties of the AGB star. METHODS: We present new spectral observations of the binary star W Aql at minimum and maximum brightness and new photometric observations of W Aql at minimum brightness. RESULTS: The composite spectrum near minimum light is predominantly from the companion at wavelengths $\lambda$ < 6000 $\AA$. This spectrum can be classified as F8 to G0, and the brightness of the companion is that of a dwarf star. Therefore, it can be concluded that the companion is a main sequence star. From this, we are able to constrain the mass of the AGB component to 1.04 - 3 $M_\odot$ and the mass of the W Aql system to 2.1 - 4.1 $M_\odot$ . Our photometric results are broadly consistent with this classification and suggest that the main sequence component suffers from approximately 2 mag of extinction in the V band primarily due to the dust surrounding the AGB component.Comment: 5 pages, 1 figure, research not

Sulphur molecules in the circumstellar envelopes of M-type AGB stars

The sulphur compounds SO and SO$_2$ have not been widely studied in the circumstellar envelopes of asymptotic giant branch (AGB) stars. By presenting and modelling a large number of SO and SO$_2$ lines in the low mass-loss rate M-type AGB star R Dor, and modelling the available lines of those molecules in a further four M-type AGB stars, we aim to determine their circumstellar abundances and distributions. We use a detailed radiative transfer analysis based on the accelerated lambda iteration method to model circumstellar SO and SO$_2$ line emission and molecular data files for both SO and SO$_2$ that are more extensive than those previously available. Using 17 SO lines and 98 SO2 lines to constrain our models for R Dor, we find an SO abundance of 6.7x10$^{-6}$ and an SO$_2$ abundance of 5x10$^{-6}$ with both species having high abundances close to the star. We also modelled $^{34}$SO and found an abundance of 3.1x10$^{-7}$, giving an $^{32}$SO/$^{34}$SO ratio of 21.6. We derive similar results for the circumstellar SO and SO$_2$ abundances and their distributions for the low mass-loss rate object W Hya. For these stars, the circumstellar SO and SO$_2$ abundances are much higher than predicted by chemical models and these two species may account for all available sulphur. For the higher mass-loss rate stars, we find shell-like SO distributions with peak abundances that decrease and peak abundance radii that increase with increasing mass-loss rate. The positions of the peak SO abundance agree very well with the photodissociation radii of H$_2$O. We find evidence that SO is most likely through the photodissociation of H$_2$O and the subsequent reaction between S and OH. The S-bearing parent molecule appears not to be H$_2$S. The SO$_2$ models suggest an origin close to the star for this species, also disagreeing with current chemical models.Comment: 25 page

Structure, bonding and morphology of hydrothermally synthesised xonotlite

The authors have systematically investigated the role of synthesis conditions upon the structure and morphology of xonotlite. Starting with a mechanochemically prepared, semicrystalline phase with Ca/Si=1, the authors have prepared a series of xonotlite samples hydrothermally, at temperatures between 200 and 250 degrees C. Analysis in each case was by X-ray photoelectron spectroscopy, environmental scanning electron microscopy and X-ray diffraction. The authors’ use of a much lower water/solid ratio has indirectly confirmed the ‘through solution’ mechanism of xonotlite formation, where silicate dissolution is a key precursor of xonotlite formation. Concerning the role of temperature, too low a temperature (~200 degrees C) fails to yield xonotlite or leads to increased number of structural defects in the silicate chains of xonotlite and too high a temperature (>250 degrees C) leads to degradation of the xonotlite structure, through leaching of interchain calcium. Synthesis duration meanwhile leads to increased silicate polymerisation due to diminishing of the defects in the silicate chains and more perfect crystal morphologies

Brain structure in pediatric Tourette syndrome

Previous studies of brain structure in Tourette syndrome (TS) have produced mixed results, and most had modest sample sizes. In the present multicenter study, we used structural magnetic resonance imaging (MRI) to compare 103 children and adolescents with TS to a well-matched group of 103 children without tics. We applied voxel-based morphometry methods to test gray matter (GM) and white matter (WM) volume differences between diagnostic groups, accounting for MRI scanner and sequence, age, sex and total GM+WM volume. The TS group demonstrated lower WM volume bilaterally in orbital and medial prefrontal cortex, and greater GM volume in posterior thalamus, hypothalamus and midbrain. These results demonstrate evidence for abnormal brain structure in children and youth with TS, consistent with and extending previous findings, and they point to new target regions and avenues of study in TS. For example, as orbital cortex is reciprocally connected with hypothalamus, structural abnormalities in these regions may relate to abnormal decision making, reinforcement learning or somatic processing in TS