151 research outputs found
Theory of magnetoresistance in films of dilute magnetic alloys
Earlier a magnetic anisotropy for magnetic impurities nearby the surface of
non-magnetic host was proposed in order to explain the size dependence of the
Kondo effect in dilute magnetic alloys. Recently Giordano has measured the
magnetoresistance of dilute Au(Fe) films for different thicknesses well above
the Kondo temperature . In this way he verified the existence of that
anisotropy even for such a case where the Kondo effect is not dominating. For
detailed comparison of that suggestion with experiments, the magnetic field
dependence of the magnetoresistance is calculated in the lowest approximation,
thus in the second order of the exchange coupling. The strength of the
anisotropy is very close to earlier estimates deduced from the size dependence
of the Kondo resistivity amplitude.Comment: (11 pages, 8 figures, essential changes compared to the old version
Effect of annealing on electron dephasing in three-dimensional polycrystalline metals
We have studied the effect of thermal annealing on electron dephasing times
in three-dimensional polycrystalline metals. Measurements are
performed on as-sputtered and annealed AuPd and Sb thick films, using
weak-localization method. In all samples, we find that possesses an
extremely weak temperature dependence as . Our results show that the
effect of annealing is non-universal, and it depends strongly on the amount of
disorder quenched in the microstructures during deposition. The observed
"saturation" behavior of cannot be easily explained by magnetic
scattering. We suggest that the issue of saturation can be better addressed in
three-dimensional, rather than lower-dimensional, structures
Kondo Effect on Mesoscopic Scale (Review)
Following the discovery of the Kondo effect the bulk transport and magnetic
behavior of the dilute magnetic alloys have been successfully described. In the
last fifteen years new directions have been developed as the study of the
systems of reduced dimensions and the artificial atoms so called quantum dots.
In this review the first subject is reviewed starting with the scanning
tunneling microscope (STM) study of a single magnetic impurity. The next
subject is the reduction of the amplitude of the Kondo effect in samples of
reduced dimension which was explained by the surface magnetic anisotropy which
blocks the motion of the integer spin nearby the surface. The electron
dephasing and energy relaxation experiments are discussed with the possible
explanation including the surface anisotropy, where the situation in cases of
integer and half-integer spins is very different. Finally, the present
situation of the theory of dynamical structural defects is briefly presented
which may lead to two-channel Kondo behavior.Comment: 8 pages, submitted to the JPSJ Special Issue "Kondo effect -- 40
years after the Discovery
Mutation patterns identify adult patients with de novo acute myeloid leukemia aged 60 years or older who respond favorably to standard chemotherapy: An analysis of Alliance studies
© 2018 Macmillan Publishers Limited, part of Springer Nature. Thus far, only 5-15% of AML patients aged ≥60 years are cured with chemotherapy. Identification of patients who are less (more) likely to respond to standard chemotherapy might enable early risk stratification toward alternative treatment regimens. We used a next-generation sequencing panel of 80 cancer- and/or leukemia-associated genes to profile molecularly 423 older patients with de novo AML. Using variables identified in multivariable models and co-occurring mutations in NPM1-mutated AML, we classified the patients into good-, intermediate-, and poor-risk groups for complete remission (CR) attainment, disease-free (DFS), and overall survival (OS). Whereas 81% of good-risk patients (comprising NPM1-mutated patients harboring mutations in chromatin remodeling, cohesin complex, methylation-related, spliceosome, and/or RAS pathway genes, FLT3-TKD, and/or patients without FLT3-ITD) achieved a CR, only 32% of poor-risk patients (with U2AF1, WT1 mutations and/or complex karyotype) did. Intermediate-risk patients had a 50% CR rate. Similarly, using NPM1 co-mutation patterns and SF1 mutation status, we identified patients with favorable DFS and OS 3-year rates of 46% and 45%, respectively. Patients with adverse genetic features had DFS and OS rates of only 2% and 4%. We show that application of our proposed criteria may refine the 2017 European LeukemiaNet classification for older patients treated with chemotheapy
NF1 mutations are recurrent in adult acute myeloid leukemia and confer poor outcome
© 2018 Macmillan Publishers Limited, part of Springer Nature Targeted mutation assessment of 81 genes in 1021 adults with de novo acute myeloid leukemia (AML) identified recurrent mutations in the neurofibromin 1 (NF1) gene in 52 (5.1%) patients, including 36 (5.2%) younger and 16 (4.8%) older patients, which suggests NF1 belongs to the 20 most frequently mutated genes in adult AML. NF1 mutations were found throughout the gene, and comprised missense, frameshift, and nonsense mutations. One mutation hotspot, at amino acid threonine 676 (Thr676), was found in 27% of AML patients with NF1 mutations. NF1-mutated patients belonged more often to the adverse European LeukemiaNet (ELN) risk category than NF1 wild-type patients. Among patients aged \u3c60 \u3eyears, the presence of NF1 Thr676 mutations was associated with lower complete remission (CR) rates (P = 0.04) and shorter overall survival (OS; P = 0.01), as was the presence of any NF1 mutation in patients in the adverse ELN risk category (CR, P = 0.05; OS, P \u3c 0.001). CR rates were also lower in NF1-mutated patients aged ≥60 years compared with NF1 wild-type patients (P = 0.001). In summary, our findings provide novel insights into the frequency of NF1 mutations in AML, and are suggestive of an adverse prognostic impact in patients treated with standard chemotherapy
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The long noncoding RNA, treRNA, decreases DNA damage and is associated with poor response to chemotherapy in chronic lymphocytic leukemia.
The study of long noncoding RNAs (lncRNAs) is an emerging area of cancer research, in part due to their ability to serve as disease biomarkers. However, few studies have investigated lncRNAs in chronic lymphocytic leukemia (CLL). We have identified one particular lncRNA, treRNA, which is overexpressed in CLL B-cells. We measured transcript expression in 144 CLL patient samples and separated samples into high or low expression of treRNA relative to the overall median. We found that high expression of treRNA is significantly associated with shorter time to treatment. High treRNA also correlates with poor prognostic indicators such as unmutated IGHV and high ZAP70 protein expression. We validated these initial findings in samples collected in a clinical trial comparing the nucleoside analog fludarabine alone or in combination with the alkylating agent cyclophosphamide in untreated CLL samples collected prior to starting therapy (E2997). High expression of treRNA was independently prognostic for shorter progression free survival in patients receiving fludarabine plus cyclophosphamide. Given these results, in order to study the role of treRNA in DNA damage response we generated a model cell line system where treRNA was over-expressed in the human B-CLL cell line OSU-CLL. Relative to the vector control line, there was less cell death in OSU-CLL over-expressing treRNA after exposure to fludarabine and mafosfamide, due in part to a reduction in DNA damage. Therefore, we suggest that treRNA is a novel biomarker in CLL associated with aggressive disease and poor response to chemotherapy through enhanced protection against cytotoxic mediated DNA damage
Size Dependence In The Disordered Kondo Problem
We study here the role randomly-placed non-magnetic scatterers play on the
Kondo effect. We show that spin relaxation effects (with time )in the
vertex corrections to the Kondo self-energy lead to an exact cancellation of
the singular temperature dependence arising from the diffusion poles. For a
thin film of thickness and a mean-free path , disorder provides a
correction to the Kondo resistivity of the form
that explains both the disorder and sample-size depression of the Kondo effect
observed by Blachly and Giordano (PRB {\bf 51}, 12537 (1995)).Comment: 11 pages, LaTeX, 2 Postscript figure
Complex karyotype in de novo acute myeloid leukemia: typical and atypical subtypes differ molecularly and clinically
© 2019, Springer Nature Limited. Complex karyotype (CK) with ≥ 3 abnormalities is detected in 10–12% of patients with acute myeloid leukemia (AML) and associated with poor prognosis. The most common unbalanced abnormalities found in CK result in loss of material from the 5q, 7q, and/or 17p chromosome arms. The presence of 5q, 7q, and/or 17p abnormalities denotes typical CK and their absence denotes atypical CK. Since molecular features of CK-AML are not well characterized, we investigated mutational status of 81 leukemia/cancer-associated genes in 160 clinically well-characterized patients. They included 136 patients with ≥ 3 exclusively unbalanced chromosome abnormalities, 96 of whom had a typical CK and 40 atypical CK, and 24 patients with ≥ 1 balanced abnormality in addition to ≥ 2 unbalanced ones. Patients with atypical CK-AML differed from those with typical CK-AML: they carried TP53 mutations less often (P \u3c 0.001) and more often PHF6 (P = 0.008), FLT3-TKD (P = 0.02), MED12 (P = 0.02), and NPM1 (P = 0.02) mutations. They were younger (P = 0.007), had higher WBC (P = 0.001) and percentages of marrow (P \u3c 0.001) and blood (P = 0.006) blasts, higher complete remission rates (P = 0.02), and longer overall survival (P \u3c 0.001), thus indicating that atypical and typical CK-AMLs constitute distinct disease subtypes. We also identified smaller patient subsets within both typical and atypical CK-AML that differed molecularly and clinically
Spin-Orbit-Induced Magnetic Anisotropy for Impurities in Metallic Samples I. Surface Anisotropy
Motivated by the recent measurements of Kondo resistivity in thin films and
wires, where the Kondo amplitude is suppressed for thinner samples, the surface
anisotropy for magnetic impurities is studied. That anisotropy is developed in
those cases where in addition to the exchange interaction with the impurity
there is strong spin-orbit interaction for conduction electrons around the
impurity in the ballistic region. The asymmetry in the neighborhood of the
magnetic impurity exhibits the anisotropy axis which, in the case of a
plane surface, is perpendicular to the surface. The anisotropy energy is
for spin , and the anisotropy constant is
inversionally proportional to distance measured from the surface and
. Thus at low temperature the spin is frozen in a singlet or doublet of
lowest energy. The influence of that anisotropy on the electrical resistivity
is the subject of the following paper (part II).Comment: 28 pages, RevTeX (using epsfig), 8 eps figures included, submitted to
PR
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