Phase diagram of turbulence in superfluid 3He-B

In superfluid 3He-B mutual-friction damping of vortex-line motion decreases roughly exponentially with temperature. We record as a function of temperature and pressure the transition from regular vortex motion at high temperatures to turbulence at low temperatures. The measurements are performed with non-invasive NMR techniques, by injecting vortex loops into a long column in vortex-free rotation. The results display the phase diagram of turbulence at high flow velocities where the transition from regular to turbulent dynamics is velocity independent. At the three measured pressures 10.2, 29.0, and 34 bar, the transition is centered at 0.52--0.59Tc and has a narrow width of 0.06Tc while at zero pressure turbulence is not observed above 0.45Tc.Comment: To be published in J. Low Temp. Phys. (QFS2004 proceedings

Splitting of a doubly quantized vortex through intertwining in Bose-Einstein condensates

The stability of doubly quantized vortices in dilute Bose-Einstein condensates of 23Na is examined at zero temperature. The eigenmode spectrum of the Bogoliubov equations for a harmonically trapped cigar-shaped condensate is computed and it is found that the doubly quantized vortex is spectrally unstable towards dissection into two singly quantized vortices. By numerically solving the full three-dimensional time-dependent Gross-Pitaevskii equation, it is found that the two singly quantized vortices intertwine before decaying. This work provides an interpretation of recent experiments [A. E. Leanhardt et al. Phys. Rev. Lett. 89, 190403 (2002)].Comment: 4 pages, 3 figures (to be published in PRA

Bleeding phenotype and diagnostic characterization of patients with congenital platelet defects

Phenotypic characterization of congenital platelet defects (CPDs) could help physicians recognize CPD subtypes and can inform on prognostic implications. We report the analyses of the bleeding phenotype and diagnostic characteristics of a large cohort of adult patients with a confirmed CPD. A total of 96 patients were analyzed and they were classified as Glanzmann thrombasthenia, Bernard-Soulier syndrome, dense granule deficiency, defects in the ADP or thromboxane A2 (TxA2) pathway, isolated thrombocytopenia or complex abnormalities. The median ISTH-BAT bleeding score was nine (IQR 5-13). Heavy menstrual bleeding (HMB) (80%), post-partum hemorrhage (74%), post-operative bleeds (64%) and post-dental extraction bleeds (57%) occurred most frequently. Rare bleeding symptoms were bleeds from the urinary tract (4%) and central nervous system (CNS) bleeds (2%). Domains with a large proportion of severe bleeds were CNS bleeding, HMB and post-dental extraction bleeding. Glanzmann thrombasthenia and female sex were associated with a more severe bleeding phenotype

Congenital platelet disorders and health status-related quality of life

Background: Patients with congenital blood platelet disorders (CPDs) demonstrate a predominantly mucocutaneous bleeding tendency. Repeated bleeds throughout life can have a significant impact on health status-related quality of life (HR-QoL), but few studies have investigated HR-QoL in patients with CPDs. Objectives: To determine HR-QoL in patients with suspected or confirmed CPDs as compared with the general Dutch population and to assess the association between bleeding phenotype and HR-QoL. Methods: Data were derived from the Thrombocytopathy in the Netherlands (TiN) study, a cross-sectional study of individuals suspected for a congenital platelet defect. TiN patients with an increased ISTH Bleeding Assessment Tool (ISTH-BAT) score (>3 in men and > 5 in women) were included for analysis. HR-QoL was assessed with the Short Form (SF)-36 survey. Bleeding symptoms were evaluated with the ISTH-BAT, resulting in a bleeding score. Results: One hundred fifty-six patients were analyzed, of whom 126 (81%) were women. Sixty-two patients (40%) had a confirmed CPD. Compared to the general Dutch population, patients with a suspected or confirmed CPD reported decreased physical functioning, limitations in daily activities due to physical health problems, limitations in social activities, decreased energy levels and fatigue, pain, and lower general health status. HR-QoL was not correlated with the ISTH-BAT score and was similar in patients with a confirmed CPD and those in whom a CPD could not be diagnosed. Conclusion: A bleeding tendency in patients with a suspected or confirmed CPD significantly impacts HR-QoL, independent of a confirmed explanatory diagnosis

Stability of multiquantum vortices in dilute Bose-Einstein condensates

Multiply quantized vortices in trapped Bose-Einstein condensates are studied using the Bogoliubov theory. Suitable combinations of a localized pinning potential and external rotation of the system are found to energetically stabilize, both locally and globally, vortices with multiple circulation quanta. We present a phase diagram for stable multiply quantized vortices in terms of the angular rotation frequency and the width of the pinning potential. We argue that multiquantum vortices could be experimentally created using these two expedients.Comment: 5 pages, 4 figure

The dynamics of vortex generation in superfluid 3He-B

A profound change occurs in the stability of quantized vortices in externally applied flow of superfluid 3He-B at temperatures ~ 0.6 Tc, owing to the rapidly decreasing damping in vortex motion with decreasing temperature. At low damping an evolving vortex may become unstable and generate a new independent vortex loop. This single-vortex instability is the generic precursor to turbulence. We investigate the instability with non-invasive NMR measurements on a rotating cylindrical sample in the intermediate temperature regime (0.3 - 0.6) Tc. From comparisons with numerical calculations we interpret that the instability occurs at the container wall, when the vortex end moves along the wall in applied flow.Comment: revised & extended version. Journal of Low Temperature Physics, accepted (2008

The limitation of genetic testing in diagnosing patients suspected for congenital platelet defects

Thrombosis and Hemostasi

Flow cytometric mepacrine fluorescence can be used for the exclusion of platelet dense granule deficiency

Background: δ-storage pool disease (δ-SPD) is a bleeding disorder characterized by a reduced number of platelet-dense granules. The diagnosis of δ-SPD depends on the measurement of platelet ADP content, but this test is time consuming and requires a relatively large blood volume. Flow cytometric analysis of platelet mepacrine uptake is a potential alternative, but this approach lacks validation, which precludes its use in a diagnostic setting. Objectives: To evaluate the performance of platelet mepacrine uptake as a diagnostic test for δ-SPD. Patients/Methods: Mepacrine fluorescence was determined with flow cytometry before and after platelet activation in 156 patients with a suspected platelet function disorder and compared with platelet ADP content as a reference test. Performance was analyzed with a receiver operating characteristic (ROC) curve. Results: Eleven of 156 patients had δ-SPD based on platelet ADP content. Mepacrine fluorescence was inferior to platelet ADP content in identifying patients with δ-SPD, but both mepacrine uptake (area under the ROC curve [AUC] 0.87) and mepacrine release after platelet activation (AUC 0.80) had good discriminative ability. In our tertiary reference center, mepacrine uptake showed high negative predicitive value (97%) with low positive predictive value (35%). Combined with a negative likelihood ratio of 0.1, these data indicate that mepacrine uptake can be used to exclude δ-SPD in patients with a bleeding tendency. Conclusion: Mepacrine fluorescence can be used as a screening tool to exclude δ-SPD in a large number of patients with a suspected platelet function disorder