6 research outputs found
La technique du ganglion sentinelle dans le mélanome (expérience du CHU de Besançon 2002-2009)
BESANCON-BU MĂ©decine pharmacie (250562102) / SudocSudocFranceF
Detection of Human Papillomavirus DNA in Plucked Eyebrow Hair from HIV-Infected Patients.
International audienc
Use of interferon-alpha in two patients with Merkel cell carcinoma positive for Merkel cell polyomavirus.
International audienc
Sentinel lymph node biopsy in melanoma: Our 8-year clinical experience in a single French institute (2002â2009)
<p>Abstract</p> <p>Background</p> <p>Since the introduction of sentinel lymph node biopsy (SLNB), its use as a standard of care for patients with clinically node-negative cutaneous melanoma remains controversial. We wished to evaluate our experience of SLNB for melanoma.</p> <p>Methods</p> <p>A single center observational cohort of 203 melanoma patients with a primary cutaneous melanoma (tumour thicknessâ>â1 mm) and without clinical evidence of metastasis was investigated from 2002 to 2009. Head and neck melanoma were excluded. SLN was identified following preoperative lymphoscintigraphy and intraoperative gamma probe interrogation.</p> <p>Results</p> <p>The SLN identification rate was 97%. The SLN was tumor positive in 44 patients (22%). Positive SLN was significantly associated with primary tumor thickness and microscopic ulceration. The median follow-up was 39.5 (5â97) months. Disease progression was significantly more frequent in SLN positive patients (32% vs 13%, pâ=â0.002). Five-year DFS and OS of the entire cohort were 79.6% and 84.6%, respectively, with a statistical significant difference between SLN positive (58.7% and 69.7%) and SLN negative (85% and 90.3%) patients (pâ=â0.0006 and pâ=â0.0096 respectively). Postoperative complications after SLNB were observed in 12% of patients.</p> <p>Conclusion</p> <p>Our data confirm previous studies and support the clinical usefulness of SLNB as a reliable and accurate staging method in patients with cutaneous melanoma. However, the benefit of additional CLND in patients with positive SLN remains to be demonstrated.</p