24 research outputs found
Genetic variability in natural populations of Zeyheria montana mart. from the Brazilian Cerrado
Anxiolytic-like effects of 4-phenyl-2-trichloromethyl-3H-1,5-benzodiazepine hydrogen sulfate in mice
FRUIT FLIES AND THEIR PARASITOIDS IN THE FRUIT GROWING REGION OF LIVRAMENTO DE NOSSA SENHORA, BAHIA, WITH RECORDS OF UNPRECEDENTED INTERACTIONS
Desempenho de juvenis de tilápia-do-nilo alimentados com rações contendo complexo enzimático
Aplicação da Calorimetria Exploratória Diferencial (DSC) para Determinação da Pureza de Fármacos Candidatos a Materiais de Referência Certificados
O trabalho aborda um estudo comparativo das
técnicas analíticas instrumentais empregadas na
determinação de pureza de compostos orgânicos, como a
Cromatografia a Líquido de Alta Eficiência, com a
Calorimetria Exploratória Diferencial, visando avaliar a sua
aplicação para a determinação direta da pureza de fármacos
candidatos a materiais de referência certificados
Anxiolytic-like effects of 4-phenyl-2-trichloromethyl-3H-1,5-benzodiazepine hydrogen sulfate in mice
The pharmacological effects of 4-phenyl-2-trichloromethyl-3H-1,5-benzodiazepine hydrogen sulfate (PTMB), a novel synthetic benzodiazepine, were examined in mice. In the elevated plus-maze test of anxiety, 0.3-1 mg/kg diazepam ip (F(3,53) = 3.78; P<0.05) and 1-10 mg/kg PTMB ip increased (F(5,98) = 3.26; P<0.01), whereas 2 mg/kg picrotoxin ip decreased (F(3,59) = 8.32; P<0.001) the proportion of time spent in the open arms, consistent with an anxiolytic action of both benzodiazepines, and an anxiogenic role for picrotoxin. In the holeboard, 1.0 mg/kg diazepam ip increased (F(3,54) = 2.78; P<0.05) and 2 mg/kg picrotoxin ip decreased (F(3,59) = 4.69; P<0.01) locomotor activity. Rotarod assessment revealed that 1 mg/kg diazepam ip and 3, 10 and 30 mg/kg PTMB ip produced significant motor incoordination compared to vehicle control (F(4,70) = 7.6; P<0.001). These data suggest that the recently synthesized PTMB compound possesses anxiolytic activity and produces motor incoordination similar to those observed with diazepam