Evaluation of Antihyperglycemic Activity of Citrus limetta Fruit Peel in Streptozotocin-Induced Diabetic Rats

The present paper aims to evaluate antihyperglycemic activity of methanol extract of Citrus limetta fruit peel (MECL) in streptozotocin-induced (STZ; 65 mg/kg b.w.) diabetic rats. Three days after STZ induction, diabetic rats received MECL orally at 200 and 400 mg kg−1 body weight daily for 15 days. Glibenclamide (0.5 mg kg−1 p. o.) was used as reference drug. Blood glucose levels were measured on 0th, 4th, 8th, and 15th days of study. Serum biochemical parameters namely, SGOT, SGPT and ALP were estimated. The TBARS and GSH levels of pancreas, kidney, and liver were determined. MECL significantly (P < 0.001) and dose dependently normalized blood glucose levels and serum biochemical parameters, decreased lipid peroxidation, and recovered GSH as compared to those of STZ control. The present paper infers that in STZ-induced diabetic Wistar rats, C. limetta fruit peel demonstrated a potential antihyperglycemic effect which may be attributed to its antioxidant property

Study on developmental toxicity and behavioral safety of <i style="mso-bidi-font-style:normal">Streblus asper </i>Lour. bark on Zebrafish embryos

255-259Streblus asper Lour. is a medicinal plant commonly found in Asia and traditionally used for a wide range of diseases. Therefore, evaluation of toxicological parameter is essential for future reference studies. In our present study methanol extract of S. asper bark (MESA) was evaluated for its developmental toxicity and behavioral safety on Zebrafish embryos up to 72 h post fertilization (hpf). This report provides the first examination of observable MESA effect on zebrafish embryos. Present study reveals the increase of heart rate directly proportional to the increase of MESA dosage with slight oedema of heart muscle at higher dose, and precautions must be taken for further use by pregnant women