10 research outputs found
Aharonov-Anandan Effect Induced by Spin-Orbit Interaction and Charge-Density-Waves in Mesoscopic Rings
We study the spin-dependent geometric phase effect in mesoscopic rings of
charge-density-wave(CDW) materials. When electron spin is explicitly taken into
account, we show that the spin-dependent Aharonov-Casher phase can have a
pronounced frustration effects on such CDW materials with appropriate electron
filling. We show that this frustration has observable consequences for
transport experiment. We identify a phase transition from a Peierls insulator
to metal, which is induced by spin-dependent phase interference effects.
Mesoscopic CDW materials and spin-dependent geometric phase effects, and their
interplay, are becoming attractive opportunities for exploitation with the
rapid development of modern fabrication technology.Comment: 5 pages, 6 figures, to appear in Phys.Rev.B(Aug.15, 1998
Interaction effects and phase relaxation in disordered systems
This paper is intended to demonstrate that there is no need to revise the
existing theory of the transport properties of disordered conductors in the
so-called weak localization regime. In particular, we demonstrate explicitly
that recent attempts to justify theoretically that the dephasing rate
(extracted from the magnetoresistance) remains finite at zero temperature are
based on the profoundly incorrect calculation. This demonstration is based on a
straightforward evaluation of the effect of the electron-electron interaction
on the weak localization correction to the conductivity of disordered metals.
Using well-controlled perturbation theory with the inverse conductance as
the small parameter, we show that this effect consists of two contributions.
First contribution comes from the processes with energy transfer smaller than
the temperature. This contribution is responsible for setting the energy scale
for the magnetoresistance. The second contribution originates from the virtual
processes with energy transfer larger than the temperature. It is shown that
the latter processes have nothing to do with the dephasing, but rather manifest
the second order (in ) correction to the conductance. This correction is
calculated for the first time. The paper also contains a brief review of the
existing experiments on the dephasing of electrons in disordered conductors and
an extended qualitative discussion of the quantum corrections to the
conductivity and to the density of electronic states in the weak localization
regime.Comment: 34 pages, 13 .eps figure
The Flux-Line Lattice in Superconductors
Magnetic flux can penetrate a type-II superconductor in form of Abrikosov
vortices. These tend to arrange in a triangular flux-line lattice (FLL) which
is more or less perturbed by material inhomogeneities that pin the flux lines,
and in high- supercon- ductors (HTSC's) also by thermal fluctuations. Many
properties of the FLL are well described by the phenomenological
Ginzburg-Landau theory or by the electromagnetic London theory, which treats
the vortex core as a singularity. In Nb alloys and HTSC's the FLL is very soft
mainly because of the large magnetic penetration depth: The shear modulus of
the FLL is thus small and the tilt modulus is dispersive and becomes very small
for short distortion wavelength. This softness of the FLL is enhanced further
by the pronounced anisotropy and layered structure of HTSC's, which strongly
increases the penetration depth for currents along the c-axis of these uniaxial
crystals and may even cause a decoupling of two-dimensional vortex lattices in
the Cu-O layers. Thermal fluctuations and softening may melt the FLL and cause
thermally activated depinning of the flux lines or of the 2D pancake vortices
in the layers. Various phase transitions are predicted for the FLL in layered
HTSC's. The linear and nonlinear magnetic response of HTSC's gives rise to
interesting effects which strongly depend on the geometry of the experiment.Comment: Review paper for Rep.Prog.Phys., 124 narrow pages. The 30 figures do
not exist as postscript file
Optimization of imidazo[4,5-b]pyridine-based kinase inhibitors: identification of a dual FLT3/aurora kinase inhibitor as an orally bioavailable preclinical development candidate for the treatment of acute myeloid leukemia
Optimization of the imidazo[4,5-b]pyridine-based series of Aurora kinase inhibitors led to the identification of 6-chloro-7-(4-(4-chlorobenzyl)piperazin-1-yl)-2-(1,3-dimethyl-1H-pyrazol-4-yl)-3H-imidazo[4,5-b]pyridine (27e), a potent inhibitor of Aurora kinases (Aurora-A K-d = 7.5 nM, Aurora-B K-d = 48 nM), FLT3 kinase (K-d = 6.2 nM), and FLT3 mutants including FLT3-ITD (K-d = 38 nM) and FLT3(D835Y) (K-d = 14 nM). FLT3-ITD causes constitutive FLT3 kinase activation and is detected in 20-35% of adults and 15% of children with acute myeloid leukemia (AML), conferring a poor prognosis in both age groups. In an in vivo setting, 27e strongly inhibited the growth of a FLT3-ITD-positive AML human tumor xenograft (MV4-11) following oral administration, with in vivo biomarker modulation and plasma free drug exposures consistent with dual FLT3 and Aurora kinase inhibition. Compound 27e, an orally bioavailable dual FLT3 and Aurora kinase inhibitor, was selected as a preclinical development candidate for the treatment of human malignancies, in particular AML, in adults and children