Combined effects of ACE (I/D) and eNOS (894T>G) genes polymorphism in patients with arterial hypertension in the realization of molecular mechanisms of left ventricular hypertrophy

Aim: To determine the frequency of alleles and genotypes of insertion-deletion (I/D) polymorphism of the angiotensin-converting enzyme (ACE) (dbSNP id: rs4646994) and a missense mutation (894T<G polymorphism) of the endothelial NO-synthase (eNOS) gene (dbSNP id: rs1799983 ) in patients with essential arterial hypertension (EAH) residents of Western Ukraine (Bukovina), depending on the severity of EAH and their association with the frequency and patterns of left ventricular hypertrophy (LVH). Materials and methods: 120 patients with EAH I-III stages (48.3% - women, 51.7% - men, average age 52.9±9.24 years) and 40 practically healthy persons were observed. Alleles of polymorphic locus was studied by polymerase chain reaction (PCR). Structural and functional changes of the myocardium and LVH models - by echocardiography, ECG. The results analyzed according to the European guidelines ESC / ESH (2009). Results and discussions: One-third of patients with EAH (35.8%) have a mutation in the coding regions of the ACE gene (I/D, intron 16, 17q23, dbSNP id: rs4646994) or eNOS (894T0.05) and “good” patterns of left ventricular geometric structure in 2.53 times (OR=7.87, p=0.04). Conclusions: ID/TG and DD/TG combination of genotypes of the ACE gene (I/D) and eNOS (893T>G) is an additional independent predictor of target-organ damage, in particular the appearance of left ventricular hypertrophy, and the severity of EAH

OPTIMIZATION OF THE SELECTION OF THE METHOD OF SEA WATER DESALINATION FOR THE REGION

Criteria for the choice of a way of desalting of sea water in the Crimean region - «study and reliability», «geographical», «industrial application», «economic», «an electric power expense», «ecological safety» and others are offered. Based on these criteria we selected the most optimal method of desalination of sea water for the Crimean region

Increase of the energy plant efficiency in special conditions of its operation

This article deals with energy plant analysis during its operation in special conditions. For this purpose, modernized system of air supply and high-temperature refrigeration is suggested. Application of these systems allows to decrease specific fuel rate by 2.6%

Increase of the energy plant efficiency in special conditions of its operation

This article deals with energy plant analysis during its operation in special conditions. For this purpose, modernized system of air supply and high-temperature refrigeration is suggested. Application of these systems allows to decrease specific fuel rate by 2.6%