Fox-Fordyce disease

Fox-Fordyce hastalığı nadir görülen, sporadik, apokrin ter bezi retansiyonu sonucu oluşan, kaşıntılı, foliküler papüllerle karakterize bir dermatozdur. Patogenezindeki en önemli basamak apokrin ter bezi duktuslarının tıkanması ve rüptürüdür. Bu makalede, Fox-Fordyce tanısı alan bir olgu sunulmuş ve literatür ışığında klinikopatolojik özellikleri tartışılmıştır.Fox-Fordyce disease is a rare and sporadic cutaneous disorder characterized by pruritic follicular papules as a result of apocrine sweat retention. The most important step in the pathogenesis of the disease is the keratinious obstruction and rupture of apocrine ducts. Herein we report a typical case of Fox-Fordyce disease and discuss the clinicopathological features of the disorder in view of the medical literature

Executive dysfunctions and depression in Behcet's disease without explicit neurological involvement

WOS: 000239010500012PubMed: 16884449This study aims to assess the executive functions and depression status in patients with Behcet's disease without explicit neurological involvement and to evaluate cognitive functions in this group of patients independent of accompanying depression. In the present study, 30 patients with Behcet's disease in the non-active phase of their illness and 30 healthy volunteers were included. In the evaluation of depression levels, Beck Depression Inventory was employed. The executive functions of the patients were evaluated by Wisconsin Card Sorting Test (WCST) and Stroop Test (ST). Beck Depression Inventory scores measured in the Behcet's disease group, in which no clinically serious depression was observed, were higher than the control group. Then, it was observed that the scores of neuropsychological tests of the Behcet's disease group were found to be significantly lower, especially in WCST, while significant relations were revealed between Beck Depression Inventory scores and WCST, ST scores. The authors' findings suggest that there may be factors other than depression causing executive impairment in patients with Behcet's disease without explicit neurological symptoms. Executive dysfunctions may occur in association with mild depressive states due to chronic disease stress or silent and/or future neurological involvement of Behcet's disease, especially in the frontal lobes

Derinin yumuşak fibromlarında insan papilloma virüsü antijenlerinin negatifliği

Giriş: Derinin yumuşak fibromlarının gerçek nedeni bilinmemekle birlikte deri yaşlanması, şişmanlık, diyabet, gebelik, menopoz, akromegali ve genetik yatkınlık ile ilişkili olabilecekleri ileri sürülmektedir. Son zamanlarda insan papilloma virüsleri de yumuşak fibrom oluşumunda potansiyel etyolojik faktör olarak suçlanmışlardır. Amaç: Bu çalışmada yumuşak fibrom etyopatogenezinde insan papilloma virüslerinin rolünün araştırılması amaçlanmış ve bu lezyonların diyabet ve obezite ile ilşkileri de sorgulanmıştır. Hastalar ve Yöntem: Bu amaçla 37 hastanın lezyonel deri örneklerinde immünhistokimyasal metod ile HPV antijenleri çalışılmıştır. Her hastadan açlık ve tokluk kan şekeri ve gayitada gizli kan tetkikleri rutin olarak istenmiştir.Bulgular: Lezyonel deri biyopsilerinden yalnızca birinde (2.7 %) HPV antijen varlığı saptanmıştır. On-üç hastanın (35.1 %) vücut kütle indeksi 30'un üstünde hesaplanmıştır. Açlık ve/ veya tokluk kan şekeri 14 hastada (37.8 %) yüksek bulunmuştur. Sonuç: Bu bulgular çok sayıda yumuşak fibrom ile başvuran hastalarda karbonhidrat metabolizmasının değerlendirilmesi gerektiğine işaret etmekte ve insan papilloma virüslerinin bu lezyonların etyolojisinde rolü olmadığını düşündürmektedir.Background: The cause of skin tags is unknown, although aging, obesity, diabetes mellitus, pregnancy, menopause, acromegaly and genetic susceptibility have been implicated as potential etiological factors. Recently a role for human papillomaviruses have been postulated in the development of these lesions. Objective: The aim of the present study was to elucidate a role for human papillomaviruses in the etiopathogenesis of skin tags. In addition, the association of skin tags with diabetes mellitus and obesity has been questioned. Methods: For this purpose lesional biopsy samples from 37 patients with skin tags were studied by immunohistochemical method for the expression of HPV antigens. As laboratory evaluation, fasting and postprandial serum glucose and fecal occult blood test were routinely performed for each patient. Results: Immunohistochemical examination showed that all but one (2.7 %) of the 37 lesional biopsy specimens lacked HPV antigens. Thirteen patients (35.1 %) had a body mass index greater than 30 (obese). Fasting and/ or postprandial serum glucose values were abnormal in 14 patients (37.8 %).Conclusion: These findings indicate that routine evaluation of carbohydrate metabolism may be important in patients presenting with multiple skin tags and that HPV can be excluded from the list of potential etiological factors in these lesions

Cognitine impairments in Behçet’s Disease without neurological involvement

Amaç: Behçet Hastalığı (BH) kronik seyirli, nörolojik tutulum yapabilen, etiyolojisi belirsiz bir hastalıktır. Nörolojik tutulum olan BH, nöro-Behçet hastalığı (NBH) olarak bilinir. Yazında BH ile ilgili nöro-psikiyatrik çalışmalar çoğunlukla NBH olan grupta yapılmıştır. Pek çok psikiyatrik ve nörolojik hastalıkta olduğu kadar, tıbbi hastalıklarda da bilişsel işlevlerin bozulduğu bilinir. Kronik hastalıklarda bilişsel işlev bozukluğu, hastalığa eşlik eden depresyona bağlı ya da ondan bağımsız olarak görülebilir. Bu çalışmanın amacı, nörolojik tutulumu olmayan BH hastalarının depresyon düzeyi ve bilişsel işlevlerinin değerlendirilmesidir. Yöntem: BH tanısı ile dermatoloji kliniği tarafından izlenen, hastalıkları açısından aktif dönemde olmayan 30 hasta ile 30 sağlıklı gönüllü çalışmaya alındı. Hastalar International Study Group (ISG) BH tanı kriterlerini karşılıyordu ve aynı kriterlere göre hiç birinde NBH yoktu. Hastaların bilişsel işlevleri Wisconsin Kart Eşleme Testi (WKET) (Wisconsin Card Sorting Test -WCST) ve Stroop Testi-TBAG Formu (ST-TBAG) ile, depresyon düzeyleri Beck Depresyon Ölçeği (BDÖ) (Beck Depression Inventory -BDI) ile değerlendirildi. Bulgular: BH grubunun test performansları daha bozuktu; yaş, cinsiyet, eğitim düzeyleri bazı test skorlarına etkiliydi, ancak BDÖ skoru ile testler arasında anlamlı ilişki saptanamadı. Sonuç: Test skorlarından elde edilen veriler, nörolojik tutulumu olmayan BH'de bilişsel işlev bozukluğuna yol açan depresyon dışında etkenler olabileceğini düşündürüyor.Objective: Behçet's Disease (BD) is a chronic disorder of unknown aetiology with neurologic involvement. BD with neurologic involvement is known as neuro-Behçet's Disease. In literature, BD related neuropsychological studies are based on mostly the neuro-BD group. The cognitive impairment is encountered in medical diseases as much as in neurologic and psychiatric diseases. The cognitive impairment in chronic diseases may be seen due to a comorbid depression or independently.The aim of this study is to assess the depression status and cognitive function in BD without neurologic involvement. Method: Thirty patients with non-active BD from the outpatient dermatology clinic and thirty matched healthy controls were studied. All patients were fulfilled the criteria of the International Study Group for BD and were excluded if they had any neurologic involvement. To assess the cognitive function and the depression status, Wisconsin Card Sorting Test -WCST, Stroop Test-TBAG version (ST-TBAG) and Beck Depression Inventory -BDI were administered respectively. Results: The test performances of the BD group, when compared with the control group, were much worse. Although some test scores were influenced by gender, age and education, there was no significant association between BDI and the test scores. Conclusion: Data obtained from the test scores suggest that the cognitive impairment in BD without neurologic involvement may be affected by various factors other than depression

PCR analysis of HSV-negative erythema multiforme for the expression of other herpesviruses

Background: Herpes simplex virus (HSV) is the primary herpesvirus implicated to have a causal role in erythema multiforme (EM), both in cases with an antecedent herpetic infection and in idiopathic EM. However, the association of EM with several other viral infections has been clearly documented. Objective: The aim of the present study was to investigate a hypothetical role for the remaining members of the herpesvirus family in HSV-negative cases of EM. Methods: Fresh, unfixed lesional skin biopsies from 25 patients with HSV-negative EM were studied for the presence of Epstein-Barr virus(EBV), cytomegalovirus (CMV), human herpesvirus-6 (HHV-6) and human herpesvirus-7 (HHV-7) by using polymerase chain reaction (PCR) and nested PCR. Results: PCR revealed the absence of specific DNA sequences for EBV, CMV, HHV-6 and HHV-7 in all lesional EM specimens analyzed. Conclusion: These findings do not support an etiological role for non-HSV members of the herpesvirus family in HSV-negative EM

Rozaseli hastalarda lezyonel ve normal deride östrojen ve progesteron reseptörlerinin araştırılması

Giriş: Rozase etyolojisinde hormonal faktörlerin rol oynayabileceğine ilişkin çok sayıda kanıt bulunmaktadır. Lezyonel deride östrojen reseptörlerinin azalması ve progesteron reseptörlerinin artışı hipotetik olarak rozase oluşumunda önemli olabilir. Amaç: Bu çalışmada rozaseli hastaların lezyonel ve normal deri dokularında östrojen ve progesteron reseptörlerinin ekspresyonunun saptanması amaçlanmıştır. Hastalar ve Yöntem: Bu amaçla rozaseli 20 hastanın lezyonel deri örneklerinde ve gönüllü 5 hastanın nonlezyonel deri örneklerinde immünhistokimyasal metod ile östrojen ve progesteron reseptörleri çalışılmıştır. Bulgular: Lezyonel deri biyopsilerinden 2'sinde (10%) progesteron reseptör varlığı saptanmış, ancak hiç bir örnekte östrojen reseptörleri gösterilememiştir. Sonuç: Bu bulgular rozase etyolojisinde östrojen ve progesteron reseptörlerinin önemi hipotezini desteklememekle birlikte bloklanamayan/ karşı konulamayan androjenik uyarı hipotezinin araştırılması gerektiğini düşündürmektedir.Background: There is a plenty of clinical evidence suggesting that rosacea may be a hormonally mediated disorder. Hypothetically, an overexpression of progesterone receptors, in conjunction with a reduced expression of estrogen receptors within the lesionalskin might play a role in the development of rosacea. Objective: The aim of the present study was to evaluate the expression of estrogen and progesterone receptors in Iesional and uninvolved skin of patients with rosacea. Methods: For this purpose 20 lesional cutaneous biopsies and 5 non-lesional cutaneous biopsies from patients with rosacea were studied by immunohistochemical method for the expression of estrogen and progesterone receptors. Results: Immunohistochemical examination showed that 2 (10%) of the 20 lesional biopsy specimens expressed progesterone receptors. None of the lesional biopsy samples expressed estrogen receptors. Conclusion: Although these findings fail to provide presumptive evidence for a role of estrogen and progesterone receptors in rosacea, there remains the possibility that unopposed androgenic stimulation might be involved in the etiopathogenesis of rosacea

The efficacy of intermittant low-dose systemic corticosteroid in the treatment of alopecia areata

Alopecia areata (AA) is a common cause of non-scarring alopecia characterized by patchy hair loss. AA is difficult to treat because of its chronic and inflammatory nature. The aim of the present study was to investigate the effect of low-dose systemic corticosteroids in the treatment of AA. Fifteen patients with AA were included in this study. Systemic prednisolone 10-15 mg/day on 2 consecutive days per week for 6 months was administered. Fourteen patients (93.3%) had patchy alopecia areata. One patient (6.3%) had alopecia universalis. Seven (46.7%) patients showed complete healing, 5 (33.3%) showed partial response and 3 (20%) did not respond to treatment. Low-dose intermittant corticosteroid therapy may be a successful and well tolerated treatment option in AA and also in patients with alopecia totalis and universalis

Vitiligo tedavisinde düşük doz, intermitan, sistemik kortikosteroid tedavisinin etkinliği

Amaç: Vitiligo depigmente lezyonlar ile karakterize, akkiz, otoimmun bir hastalıktır. Çalısmanın amacı düşük doz, sistemik kortikosteroid tedavisinin vitiligo tedavisindeki rolünü araştırmaktır.Gereç ve Yöntemler: Calışmamıza 16 hasta dahil edilmiştir. Sistemik prednizolon 10-15 mg/gün, haftanın 2 ardışık günü, 6 ay süre ile uygulanmıştır.Bulgular: 14 hastada non-segmental [10 (62.5%) simetrik jeneralize- 4 (25%) akrofasyal) ve 2 (12.5%)] hastada segmental vitiligo tespit edildi. Altı aylık tedavi sonrasinda 6 (37.5%) hastada foliküler repigmentasyon, tespit edilirken 10 (62.5%) hastada tedaviye yanıt alınamadı. Hastaların hiçbirinde tam düzelme tespit edilmedi.Sonuç: İntermitan, düşük doz sistemik kortikosteroid vitiligo tedavisinde etkili bulunmamıştır.Objective: Vitiligo is an autoimmune, acquired, pigmentary anomaly of the skin, characterized by depigmented patches. The aim of the present study was to investigate the effect of low-dose systemic corticosteroids in the treatment of vitiligo.Material and Methods: 16 patients with vitiligo were included in this study. Systemic prednisolone at a dose of 10-15 mg/day was administered for two consequtive days of week for 6 months.Results: 14 patients had non-segmental [10 (62.5% ) symmetric generalized – 4 ( 25 %) acrofacial )] and 2 (12.5%) patients had segmental vitiligo. After 6 months of treatment 6 (37.5%) patients showed follicular repigmentation, while 10 of them (62.5 %) did not respond to therapy. None of them showed complete healing. Conclusion: Intermittant low dose systemic corticosteroid therapy is not an effective treatment option in vitiligo

Increased tumor necrosis factor alpha (TNF-alpha) and interleukin 1 alpha (IL1-alpha) levels in the lesional skin of patients with nonsegmental vitiligo

KISA, Ucler/0000-0002-8131-6810WOS: 000239899800027PubMed: 16911396