Biodistribution of 64 Cu in Inflamed Rats Following Administration of Two Anti-Inflammatory Copper Complexes

64Cu was administered in two anti-inflammatory formulations to normal rats and to rats with 2 forms of local inflammation, namely (a) an acute paw oedema (elicited with carrageenan) or (b) a chronic granulomatous response to an implanted irritant (Mycobacterium tuberculosis in a polyurethane sponge). The copper formulations used were (i) a slow release one consisting of Cu(II) salicylate applied dermally with ethanol/DMSO and (ii) short acting hydrophilic complex (Cu(I)Cu(II)-penicillamine)5- given subcutaneously. Three types of changes in copper biodistribution with these forms of inflammation were discerned based on determination of 64Cu and copper content in the following organs: inflammatory locus (foot or sponge implant), kidney, liver, spleen, adrenals, brain, blood, thymus, heart, and skin (site of application). The most evident changes were in the kidneys, liver, spleen, adrenals, thymus and serum from animals with chronic granulomatous inflammation. In contrast, a short term acute inflammatory stress (carrageenan paw oedema) had little effect. While copper D-penicillamine (applied subcutaneously) appeared to move as a bolus through the animals, the results with the percutaneous copper salicylate formulation are consistent with it providing a slow release source of copper(II). Exogenous 64Cu from both formulations was sequestered at inflammatory sites (relative to serum). This may partly explain how applied copper complexes can be anti-inflammatory

Spin-triplet cobalt complexes of biuret and related ligands

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Copper(III) and nickel(III) complexes of biuret and oxamide

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The tris(biuretato)cobaltate(III) ion: The crystal structure of potassium tris(biuretato)cobaltate(III) hydrate

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Copper(I) and copper(II) compounds of 1,7-bis(2-benzimidazolyl)-2,6-dithiaheptane (BBDHp). X-ray structure of linearly coordinated copper(I) in the cation [CuI(BBDHp)]+

Original article can be found at: http://pubs.acs.org/journals/inocaj/index.html Copyright American Chemical Society DOI: 10.1021/ic00137a021 [Full text of this article is not available in the UHRA]Peer reviewe

MAGNETIC FOCUSING OF ELECTRONS IN COPPER SINGLE CRYSTALS

Il est possible d'étudier la focalisation magnétique des électrons dans des cristaux métalliques à l'aide de contacts à pointe. Des expériences avec des cristaux de cuivre montrent des réflexions internes contre la surface. La réaction lente de la tension mesurée à chaque changement du courant injecté peut être interprétée par des effets inductifs et explique l'échec des mesures effectuées en utilisant un courant alternatif.Magnetic focusing of electrons in métal single crystals can be studied by injecting and detecting electrons via point-contacts. Experiments performed on copper single crystals show clearly internal reflections at the surface. The observed reluctance of the detected voltage to respond to changes in the injected current can be understood on the basis of inductive effects and explains the failure of attempted AC measurements