Use of Failure Mode and Effects Analysis (FMEA) for Risk Analysis of Drug Use in Patients with Lung Cancer

It is crucial to investigate the risk factors inherent in the medication process for cancer patients since improper antineoplastic drug use frequently has serious consequences. As a result, the Severity, Occurrence, and Detection rate of each potential failure mode in the drug administration process for patients with lung cancer were scored using the Failure Mode and Effect Analysis (FMEA) model in this study. Then, the risk level of each failure mode and the direction of improvement were investigated using the Slacks-based measure data envelopment analysis (SBM-DEA) model. According to the findings, the medicine administration process for lung cancer patients could be classified into five links, with a total of 60 failure modes. The risk of failure modes for patient medication and post-medication monitoring ranked highly, with unauthorized use of traditional Chinese medicine and folk prescription and unauthorized drug addition (incorrect self-medication) ranking first (1/60); doctor prescription was also prone to errors. The study advises actively looking at ways to decrease the occurrence and difficulty of failure mode detection to continually enhance patient safety when using medications

Modulation of Growth Duration, Grain Yield and Nitrogen Recovery Efficiency by EMS Mutagenesis under <i>OsNRT2.3b</i> Overexpression Background in Rice

Growth duration is an important agronomic trait that determines the season and area of crop growth. Previous experiments showed that overexpression of nitrate transporter OsNRT2.3b significantly increased rice yield, nitrogen use efficiency, and growth duration. Through screening, we obtained four ethyl methanesulfonate (EMS)-mutagenized mutants with shorter growth duration compared with O8 of OsNRT2.3b overexpression line. The nitrogen translocation efficiency and physiological nitrogen use efficiency of the mutants were not significantly different from O8, which were increased by 24.4% and 14.2%, respectively compared with WT, but the growth duration of the mutant was significantly lower than O8. Analysis of O8 and mutants showed that the growth duration positively correlated with grain weight per panicle, grain yield, and nitrogen recovery efficiency. In conclusion, our results provide a new idea for balancing rice yield and growth duration

Safety analysis of antineoplastic drugs for lung cancer: a retrospective analysis based on Shaanxi Province in Western China

China has the highest proportion of lung cancer-related deaths. Drug therapy is the main tool of comprehensive anticancer treatment. However, most studies to date have focused on certain types of targets or immunotherapeutic modalities for drug safety; few studies have addressed the factors that influence ADRs for each type of drug in patients with lung cancer, and even fewer studies have explored the risk factors for certain types of ADRs. Based on it, we comprehensively evaluate the drug safety of patients and provide a clinical reference with a focus on lung cancer. We examined 767 reports of adverse drug reactions (ADRs) in patients with lung cancer and conducted a logistic regression analysis on the risk factors that may cause different types of organ system damage and serious ADRs. The logistic regression identified various independent risk factors for system organ damage, and ADRs involving erythrocyte abnormalities (P  Rare adverse reactions and different Clinical medication guidelines for molecular-targeted drugs were identified. These findings had certain practical significance in clinical safe drug use.</p