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Editorial board of the “Biophysical bulletin” scientific journal in this difficult time, together with all Ukrainian people, is continuing to work to restore the peaceful life in Ukraine as soon as possible

A novel role for myosin II in insulin-stimulated glucose uptake in 3T3-L1 adipocytes

Abstract: Insulin-stimulated glucose uptake requires the activation of several signaling pathways to mediate the translocation and fusion of GLUT4 vesicles from an intracellular pool to the plasma membrane. The studies presented here show that inhibition of myosin II activity impairs GLUT4-mediated glucose uptake but not GLUT4 translocation to the plasma membrane. We also show that adipocytes express both myosin IIA and IIB isoforms, and that myosin IIA is recruited to the plasma membrane upon insulin stimulation. Taken together, the data presented here represent the first demonstration that GLUT4-mediated glucose uptake is a myosin IIdependent process in adipocytes. Based on our findings, we hypothesize that myosin II is activated upon insulin stimulation and recruited to the cell cortex to facilitate GLUT4 fusion with the plasma membrane. The identification of myosin II as a key component of GLUT4-mediated glucose uptake represents an important advance in our understanding of the mechanisms regulating glucose homeostasis. Keywords: Myosin II; Blebbistatin; Glucose uptake; Adipocytes Article: Glucose uptake is the rate-limiting step in glucose utilization in adipocytes. Insulin-stimulated glucose uptake requires the activation of several signaling pathways that stimulate the translocation and fusion of glucose transporter (GLUT4)-containing vesicles to the plasma membrane (reviewe

CAMAC 580 (8-bit PC, co-processor, perifery processor) with DMA Channel

Document scanning and optical character recognition: O.V. Gradov's Group [Biophysical Instrumentation Group], P.L. Alexandrov. Gradov's Group Project: Russian CAMAC Society

MEDICOR MC-3 (compact / handheld electrocardioscope)

Document imaging and (optionally) OCR: O.V. Gradov's Group [Biophysical Instrumentation Group]. Gradov's Group Project: MEDICOR Deltiology

CAMAC Semiconductor Memory Device 29166-00000-001 (type 203)

Document scanning and optical character recognition: O.V. Gradov's Group [Biophysical Instrumentation Group], P.L. Alexandrov. Gradov's Group Project: Russian CAMAC Society

MEDICOR ATK-5 (Clinical Audiometer)

Document imaging and (optionally) OCR: O.V. Gradov's Group [Biophysical Instrumentation Group]. Gradov's Group Project: MEDICOR Deltiology

CAMAC Relay Multiplexer (type 753-1, 753-2); 27766-00000-002

Document scanning and optical character recognition: O.V. Gradov's Group [Biophysical Instrumentation Group], P.L. Alexandrov. Gradov's Group Project: Russian CAMAC Society