Bayesian Model Selection with Future 21cm Observations of The Epoch of Reionisation

We apply Bayesian statistics to perform model selection on different reionisation scenarios via the Multinest algorithm. Initially, we recover the results shown by 21CMMC for the parameter estimation of 21cmFAST models. We proceed to test several toy models of the Epoch of Reionisation (EoR) defined in contrasting morphology and scale. We find that LOFAR observations are unlikely to allow model selection even with long integration times. HERA would require 61 dipoles to perform the same analysis in 1080 hours, and becomes comparable to the SKA with 217 dipoles. We find the SKA requires only 324 hours of observation to conclusively distinguish between our models. Once model selection is achievable, an analysis of observational priors is performed finding that neutral fraction checks at specific redshifts add little to no inference. We show the difficulties in model selection at the level of distinguishing fiducial parameters within a model or distinguishing galaxies with a constant versus power law mass-to-light ratio. Finally, we explore the use of the Savage-Dickey density ratio to show the redundancy of the parameter Rmfp within 21cmFAST.Comment: 20 pages, 16 figures - Accepted for publication by MNRA

In situ-produced cosmogenic krypton in zircon and its potential for Earth surface applications

Analysis of cosmogenic nuclides produced in surface rocks and sediments is a valuable tool for assessing the rates of processes and the timing of events that shaped the Earth surface. The various nuclides that are used have specific advantages and limitations that depend on the time range over which they are useful, the type of material they are produced in and not least the feasibility of the analytical effort. Anticipating novel applications in Earth surface sciences, we develop in situ-produced terrestrial cosmogenic krypton (Krit) as a new tool, the motivation being the availability of six stable and one radioactive isotope (81Kr, half-life 229 kyr) and of an extremely weathering-resistant target mineral (zircon). We provide proof of principle that terrestrial Krit can be quantified and used to unravel Earth surface processes.</p

Recombinant Fibrinogen Studies Reveal That Thrombin Specificity Dictates Order of Fibrinopeptide Release

During cleavage of fibrinogen by thrombin, fibrinopeptide A (FpA) release precedes fibrinopeptide B (FpB) release. To examine the basis for this ordered release, we synthesized A'beta fibrinogen, replacing FpB with a fibrinopeptide A-like peptide, FpA' (G14V). Analyses of fibrinopeptide release from A'beta fibrinogen showed that FpA release and FpA' release were similar; the release of either peptide followed simple first-order kinetics. Specificity constants for FpA and FpA' were similar, demonstrating that these peptides are equally competitive substrates for thrombin. In the presence of Gly-Pro-Arg-Pro, an inhibitor of fibrin polymerization, the rate of FpB release from normal fibrinogen was reduced 3-fold, consistent with previous data; in contrast, the rate of FpA' release from A'beta fibrinogen was unaffected. Thus, with A'beta fibrinogen, fibrinopeptide release from the beta chain is similar to fibrinopeptide release from the alpha chain. We conclude that the ordered release of fibrinopeptides is dictated by the specificity of thrombin for its substrates. We analyzed polymerization, following changes in turbidity, and found that polymerization of A'beta fibrinogen was similar to that of normal fibrinogen. We analyzed clot structure by scanning electron microscopy and found that clots from A'beta fibrinogen were similar to clots from normal fibrinogen. We conclude that premature release of the fibrinopeptide from the N terminus of the beta chain does not affect polymerization of fibrinogen

Holocene warming of alpine rockwalls decreased rockwall erosion rates

Alpine rockwall erosion studies suggest that deglaciated rockwalls in the European Alps are eroding slower today than at earlier times in the Holocene. Explanations for this have included a waned glacial debuttressing effect since the retreat of Last Glacial ice loads and the establishment of more moderate climates, but seldom have such explanations been robustly tested. We combine field data with modelling to reconstruct changes in rockwall erosion and associated climate drivers, in an alpine valley of the European Alps since the beginning of the Holocene. Paleo (Holocene to decadal-scale) erosion rates were calculated from talus accumulation below rockwalls, and compared with recent rates (2016–2019) measured from repeat laserscan surveys of the same rockwalls. We reconstructed the glacial retreat history in the valley, and modelled Holocene changes in permafrost distribution and frost cracking using calibrated rockwall temperature reconstructions. We found that rockwalls that have been free of glacier ice since ∼10 ka experienced higher Holocene-averaged erosion rates compared to recent erosion rates. Our modelling suggests this relates to periods of higher intensities of frost cracking and cycles of permafrost aggradation and degradation in the Holocene, relative to today. For a recently deglaciated high-elevation rockwall, erosion rates were 1–2 orders of magnitude greater than the lower-elevation sites, but decayed rapidly over time since deglaciation. A high, but rapidly decaying rate results from short-lived paraglacial adjustment, permafrost thaw and high frost cracking activity. Our findings suggest that periglacial activity strongly influences the rates and patterns of erosion of deglaciated alpine rockwalls. This helps to explain why paleo Holocene deglaciated rockwall erosion rates tend to exceed recent rates in the European Alps

ChronoLorica: introduction of a soil–landscape evolution model combined with geochronometers

Understanding long-term soil and landscape evolution can help us understand the threats to current-day soils, landscapes and their functions. The temporal evolution of soils and landscapes can be studied using geochronometers, such as optically stimulated luminescence (OSL) particle ages or radionuclide inventories. Also, soil–landscape evolution models (SLEMs) can be used to study the spatial and temporal evolution of soils and landscapes through numerical modelling of the processes responsible for the evolution. SLEMs and geochronometers have been combined in the past, but often these couplings focus on a single geochronometer, are designed for specific idealized landscape positions, or do not consider multiple transport processes or post-depositional mixing processes that can disturb the geochronometers in sedimentary archives. We present ChronoLorica, a coupling of the soil–landscape evolution model Lorica with a geochronological module. The module traces spatiotemporal patterns of particle ages, analogous to OSL ages, and radionuclide inventories during the simulations of soil and landscape evolution. The geochronological module opens rich possibilities for data-based calibration of simulated model processes, which include natural processes, such as bioturbation and soil creep, as well as anthropogenic processes, such as tillage. Moreover, ChronoLorica can be applied to transient landscapes that are subject to complex, non-linear boundary conditions, such as land use intensification, and processes of post-depositional disturbance which often result in complex geo-archives. In this contribution, we illustrate the model functionality and applicability by simulating soil and landscape evolution along a two-dimensional hillslope. We show how the model simulates the development of the following three geochronometers: OSL particle ages, meteoric 10Be inventories and in situ 10Be inventories. The results are compared with field observations from comparable landscapes. We also discuss the limitations of the model and highlight its potential applications in pedogenical, geomorphological or geological studies.</p

Why is there no queer international theory?

Over the last decade, Queer Studies have become Global Queer Studies, generating significant insights into key international political processes. Yet, the transformation from Queer to Global Queer has left the discipline of International Relations largely unaffected, which begs the question: if Queer Studies has gone global, why has the discipline of International Relations not gone somewhat queer? Or, to put it in Martin Wight’s provocative terms, why is there no Queer International Theory? This article claims that the presumed non-existence of Queer International Theory is an effect of how the discipline of International Relations combines homologization, figuration, and gentrification to code various types of theory as failures in order to manage the conduct of international theorizing in all its forms. This means there are generalizable lessons to be drawn from how the discipline categorizes Queer International Theory out of existence to bring a specific understanding of International Relations into existence

Nebuliser therapy in the intensive care unit

The relationship between identity, lived experience, sexual practices and the language through which these are conveyed has been widely debated in sexuality literature. For example, ‘coming out’ has famously been conceptualised as a ‘speech act’ (Sedgwick 1990) and as a collective narrative (Plummer 1995), while a growing concern for individuals’ diverse identifications in relations to their sexual and gender practices has produced interesting research focusing on linguistic practices among LGBT-identified individuals (Leap 1995; Kulick 2000; Cameron and Kulick 2006; Farqhar 2000). While an explicit focus on language remains marginal to literature on sexualities (Kulick 2000), issue of language use and translation are seldom explicitly addressed in the growing literature on intersectionality. Yet intersectional perspectives ‘reject the separability of analytical and identity categories’ (McCall 2005:1771), and therefore have an implicit stake in the ‘vernacular’ language of the researched, in the ‘scientific’ language of the researcher and in the relationship of continuity between the two. Drawing on literature within gay and lesbian/queer studies and cross-cultural studies, this chapter revisits debates on sexuality, language and intersectionality. I argue for the importance of giving careful consideration to the language we choose to use as researchers to collectively define the people whose experiences we try to capture. I also propose that language itself can be investigated as a productive way to foreground how individual and collective identifications are discursively constructed, and to unpack the diversity of lived experience. I address intersectional complexity as a methodological issue, where methodology is understood not only as the methods and practicalities of doing research, but more broadly as ‘a coherent set of ideas about the philosophy, methods and data that underlie the research process and the production of knowledge’ (McCall 2005:1774). My points are illustrated with examples drawn from my ethnographic study on ‘lesbian’ identity in urban Russia, interspersed with insights from existing literature. In particular, I aim to show that an explicit focus on language can be a productive way to explore the intersections between the global, the national and the local in cross-cultural research on sexuality, while also addressing issues of positionality and accountability to the communities researched

Atypical audiovisual speech integration in infants at risk for autism

The language difficulties often seen in individuals with autism might stem from an inability to integrate audiovisual information, a skill important for language development. We investigated whether 9-month-old siblings of older children with autism, who are at an increased risk of developing autism, are able to integrate audiovisual speech cues. We used an eye-tracker to record where infants looked when shown a screen displaying two faces of the same model, where one face is articulating/ba/and the other/ga/, with one face congruent with the syllable sound being presented simultaneously, the other face incongruent. This method was successful in showing that infants at low risk can integrate audiovisual speech: they looked for the same amount of time at the mouths in both the fusible visual/ga/− audio/ba/and the congruent visual/ba/− audio/ba/displays, indicating that the auditory and visual streams fuse into a McGurk-type of syllabic percept in the incongruent condition. It also showed that low-risk infants could perceive a mismatch between auditory and visual cues: they looked longer at the mouth in the mismatched, non-fusible visual/ba/− audio/ga/display compared with the congruent visual/ga/− audio/ga/display, demonstrating that they perceive an uncommon, and therefore interesting, speech-like percept when looking at the incongruent mouth (repeated ANOVA: displays x fusion/mismatch conditions interaction: F(1,16) = 17.153, p = 0.001). The looking behaviour of high-risk infants did not differ according to the type of display, suggesting difficulties in matching auditory and visual information (repeated ANOVA, displays x conditions interaction: F(1,25) = 0.09, p = 0.767), in contrast to low-risk infants (repeated ANOVA: displays x conditions x low/high-risk groups interaction: F(1,41) = 4.466, p = 0.041). In some cases this reduced ability might lead to the poor communication skills characteristic of autism

'Sexercise': Working out heterosexuality in Jane Fonda’s fitness books

This is an Author's Accepted Manuscript of an article published in Leisure Studies, 30(2), 237 - 255, 2011, copyright Taylor & Francis, available online at: http://www.tandfonline.com/10.1080/02614367.2010.523837.This paper explores the connection between the promotion of heterosexual norms in women’s fitness books written by or in the name of Jane Fonda during the 1980s and the commodification of women’s fitness space in both the public and private spheres. The paper is set in the absence of overt discussions of normative heterosexuality in leisure studies and draws on critical heterosexual scholarship as well as the growing body of work theorising geographies of corporeality and heterosexuality. Using the principles of media discourse analysis, the paper identifies three overlapping characteristics of heterosexuality represented in Jane Fonda’s fitness books, and embodied through the exercise regimes: respectable heterosexual desire, monogamous procreation and domesticity. The paper concludes that the promotion and prescription of exercise for women in the Jane Fonda workout books centred on the reproduction and embodiment of heterosexual corporeality. Set within an emerging commercial landscape of women’s fitness in the 1980s, such exercise practices were significant in the legitimation and institutionalisation of heteronormativity