Soft BPR Loss for Dynamic Hard Negative Sampling in Recommender Systems

In recommender systems, leveraging Graph Neural Networks (GNNs) to formulate the bipartite relation between users and items is a promising way. However, powerful negative sampling methods that is adapted to GNN-based recommenders still requires a lot of efforts. One critical gap is that it is rather tough to distinguish real negatives from massive unobserved items during hard negative sampling. Towards this problem, this paper develops a novel hard negative sampling method for GNN-based recommendation systems by simply reformulating the loss function. We conduct various experiments on three datasets, demonstrating that the method proposed outperforms a set of state-of-the-art benchmarks.Comment: 9 pages, 16 figure

FreeMask: Synthetic Images with Dense Annotations Make Stronger Segmentation Models

Semantic segmentation has witnessed tremendous progress due to the proposal of various advanced network architectures. However, they are extremely hungry for delicate annotations to train, and the acquisition is laborious and unaffordable. Therefore, we present FreeMask in this work, which resorts to synthetic images from generative models to ease the burden of both data collection and annotation procedures. Concretely, we first synthesize abundant training images conditioned on the semantic masks provided by realistic datasets. This yields extra well-aligned image-mask training pairs for semantic segmentation models. We surprisingly observe that, solely trained with synthetic images, we already achieve comparable performance with real ones (e.g., 48.3 vs. 48.5 mIoU on ADE20K, and 49.3 vs. 50.5 on COCO-Stuff). Then, we investigate the role of synthetic images by joint training with real images, or pre-training for real images. Meantime, we design a robust filtering principle to suppress incorrectly synthesized regions. In addition, we propose to inequally treat different semantic masks to prioritize those harder ones and sample more corresponding synthetic images for them. As a result, either jointly trained or pre-trained with our filtered and re-sampled synthesized images, segmentation models can be greatly enhanced, e.g., from 48.7 to 52.0 on ADE20K. Code is available at https://github.com/LiheYoung/FreeMask.Comment: Accepted by NeurIPS 202

Protection of Pentoxifylline against Testis Injury Induced by Intermittent Hypobaric Hypoxia

To investigate the effect of pentoxifylline (PTX) on spermatogenesis dysfunction induced by intermittent hypobaric hypoxia (IHH) and unveil the underlying mechanism, experimental animals were assigned to Control, IHH+Vehicle, and IHH+PTX groups and exposed to 4 cycles of 96 h of hypobaric hypoxia followed by 96 h of normobaric normoxia for 32 days. PTX was administered for 32 days. Blood and tissue samples were collected 7 days thereafter. Serum malondialdehyde levels were used to assess lipid peroxidation; ferric-reducing antioxidant power (FRAP), superoxide dismutase, and catalase and glutathione peroxidase enzyme activities were assessed to determine antioxidant capacity in various samples. Testis histopathology was assessed after hematoxylin-eosin staining by Johnsen’s testicular scoring system. Meanwhile, testosterone synthase and vimentin amounts were assessed by immunohistochemistry. Sperm count, motility, and density were assessed to determine epididymal sperm quality. IHH treatment induced significant pathological changes in testicular tissue and enhanced serum lipid peroxide levels, while reducing serum FRAP, antioxidant enzyme activities, and testosterone synthase expression. Moreover, IHH impaired epididymal sperm quality and vimentin structure in Sertoli cells. Oral administration of PTX improved the pathological changes in the testis. IHH may impair spermatogenesis function of testicular tissues by inducing oxidative stress, but this impairment could be attenuated by administration of PTX

Cytochrome P450 enzymes in the black-spotted frog (Pelophylax nigromaculatus): molecular characterization and upregulation of expression by sulfamethoxazole

Cytochrome P450 (CYP) enzymes are crucial for the detoxification of xenobiotics, cellular metabolism, and homeostasis. This study investigated the molecular characterization of CYP enzymes in the black-spotted frog, Pelophylax nigromaculatus, and examined the regulation of CYP expression in response to chronic exposure to the antibiotic sulfamethoxazole (SMX) at various environmental concentrations (0, 1, 10, and 100 μg/L). The full-length cDNA of Pn-CYP26B1 was identified. The sequence included open reading frames of 1,536 bp, encoding proteins comprising 511 amino acids. The signature motif, FxxGxxxCxG, was highly conserved when compared with a number of selected animal species. SMX significantly upregulated the expression of the protein CYP26B1 in frog livers at concentrations of 1 and 10 μg/L. SMX showed an affinity for CYP26B1 of −7.6 kcal/mol, indicating a potential mechanism for SMX detoxification or adaptation of the frog. These findings contributed to our understanding of the environmental impact of antibiotics on amphibian species and underscored the importance of CYP enzymes in maintaining biochemical homeostasis under exposure to xenobiotic stress

Shear Characteristics of Soil—Concrete Structure Interaction Interfaces

The shear characteristics of the interfaces between soil and concrete structures are essential for the safety of the structures. In this study, a large-scale direct shear test apparatus was developed to measure the mechanical parameters of soil–concrete interfaces under conditions with different soil types, soil moisture contents, and interfacial filling materials. The results showed that the shear stress of the soil–concrete interface increased initially and then became stable with the increase in the shear displacement. The shear displacement of the sandy soil when the shear stress became stable was smaller than that of the clayey soil. The silty sand–concrete interface had a smaller friction angle than the interface with the medium-coarse sand. Moreover, with the increase in the soil moisture content, the friction angle of the clayey soil–concrete interface decreased rapidly, whereas the cohesion first increased and then decreased, and the peak cohesion was near the plastic limit of the soil. Under the same moisture content, the friction angle and cohesion of the clay–concrete interface was reduced by filling the interface with a thin layer of sandy soil, while filling the silty sand–concrete interface with a thin layer of silt reduced the friction angle and increased the interfacial cohesion. Nonetheless, the filling had little impact on the overall shear strength of the interface

Comparative Analysis for the Urban Metabolic Differences of Two Types of Cities in the Resource-Dependent Region Based on Emergy Theory

Urban metabolism analysis has become a useful and effective tool to explore urban socio-economic processes. In this research, in order to explore the similarities and differences of metabolic characteristics and variation rules of different types of resource-dependent cities, we selected two cities—Taiyuan and Jincheng, the capital and a traditional resource-dependent city of Shanxi province, respectively, as research subjects, we also established an urban metabolic evaluation framework by employing a set of eight emergy-based indicators from socio-economic data from 2007 to 2014, and compared the similarities and discrepancies from the perspectives of metabolic structure, intensity, pressure, and efficiency, and put forward some suggestions for pursuing sustainable development for both cities and pointed out that more types of resource-dependent cities should be incorporated in future research work

Shear Characteristics of Soil—Concrete Structure Interaction Interfaces

The shear characteristics of the interfaces between soil and concrete structures are essential for the safety of the structures. In this study, a large-scale direct shear test apparatus was developed to measure the mechanical parameters of soil–concrete interfaces under conditions with different soil types, soil moisture contents, and interfacial filling materials. The results showed that the shear stress of the soil–concrete interface increased initially and then became stable with the increase in the shear displacement. The shear displacement of the sandy soil when the shear stress became stable was smaller than that of the clayey soil. The silty sand–concrete interface had a smaller friction angle than the interface with the medium-coarse sand. Moreover, with the increase in the soil moisture content, the friction angle of the clayey soil–concrete interface decreased rapidly, whereas the cohesion first increased and then decreased, and the peak cohesion was near the plastic limit of the soil. Under the same moisture content, the friction angle and cohesion of the clay–concrete interface was reduced by filling the interface with a thin layer of sandy soil, while filling the silty sand–concrete interface with a thin layer of silt reduced the friction angle and increased the interfacial cohesion. Nonetheless, the filling had little impact on the overall shear strength of the interface

Data_Sheet_3_Componential usage patterns in dengue 4 viruses reveal their better evolutionary adaptation to humans.doc

There have been at least four types of dengue outbreaks in the past few years. The evolutionary characteristics of dengue viruses have aroused great concerns. The evolutionary characteristics of dengue 4 viruses are studied in the present study based on their base usage patterns and codon usage patterns. The effective number of codons and relative synonymous codon usage (RSCU) values of four types of dengue viruses were counted or calculated. The Kullback–Leibler (K–L) divergences of relative synonymous codon usage from dengue viruses to humans and the Kullback–Leibler divergences of amino acid usage patterns from dengue viruses to humans were calculated to explore the adaptation levels of dengue viruses. The results suggested that: (1) codon adaptation in dengue 4 viruses occurred through an evolutionary process from 1956 to 2021, (2) overall relative synonymous codon usage values of dengue 4 viruses showed more similarities to humans than those of other subtypes of dengue viruses, and (3) the smaller Kullback–Leibler divergence of amino acid usage and relative synonymous codon usage from dengue viruses to humans indicated that the dengue 4 viruses adapted to human hosts better. All results indicated that both mutation pressure and natural selection pressure contributed to the codon usage pattern of dengue 4 viruses more obvious than to other subtypes of dengue viruses and that the dengue 4 viruses adapted to human hosts better than other types of dengue viruses during their evolutionary process.</p

Data_Sheet_1_Componential usage patterns in dengue 4 viruses reveal their better evolutionary adaptation to humans.xls

There have been at least four types of dengue outbreaks in the past few years. The evolutionary characteristics of dengue viruses have aroused great concerns. The evolutionary characteristics of dengue 4 viruses are studied in the present study based on their base usage patterns and codon usage patterns. The effective number of codons and relative synonymous codon usage (RSCU) values of four types of dengue viruses were counted or calculated. The Kullback–Leibler (K–L) divergences of relative synonymous codon usage from dengue viruses to humans and the Kullback–Leibler divergences of amino acid usage patterns from dengue viruses to humans were calculated to explore the adaptation levels of dengue viruses. The results suggested that: (1) codon adaptation in dengue 4 viruses occurred through an evolutionary process from 1956 to 2021, (2) overall relative synonymous codon usage values of dengue 4 viruses showed more similarities to humans than those of other subtypes of dengue viruses, and (3) the smaller Kullback–Leibler divergence of amino acid usage and relative synonymous codon usage from dengue viruses to humans indicated that the dengue 4 viruses adapted to human hosts better. All results indicated that both mutation pressure and natural selection pressure contributed to the codon usage pattern of dengue 4 viruses more obvious than to other subtypes of dengue viruses and that the dengue 4 viruses adapted to human hosts better than other types of dengue viruses during their evolutionary process.</p