1 research outputs found
Surface-Enhanced Raman Scattering Active Plasmonic Nanoparticles with Ultrasmall Interior Nanogap for Multiplex Quantitative Detection and Cancer Cell Imaging
Due to its large enhancement effect,
nanostructure-based surface-enhanced
Raman scattering (SERS) technology had been widely applied for bioanalysis
and cell imaging. However, most SERS nanostructures suffer from poor
signal reproducibility, which hinders the application of SERS nanostructures
in quantitative detection. We report an etching-assisted approach
to synthesize SERS-active plasmonic nanoparticles with 1 nm interior
nanogap for multiplex quantitative detection and cancer cell imaging.
Raman dyes and methoxy polyÂ(ethylene glycol) thiol (mPEG–SH)
were attached to gold nanoparticles (AuNPs) to prepare gold cores.
Next, Ag atoms were deposited on gold cores in the presence of Pluronic
F127 to form a Ag shell. HAuCl<sub>4</sub> was used to etch the Ag
shell and form an interior nanogap in Au@AgAuNPs, leading to increased
Raman intensity of dyes. SERS intensity distribution of Au@AgAuNPs
was found to be more uniform than that of aggregated AuNPs. Finally,
Au@AgAuNPs were used for multiplex quantitative detection and cancer
cell imaging. With the advantages of simple and rapid preparation
of Au@AgAuNPs with highly uniform, stable, and reproducible Raman
intensity, the method reported here will widen the applications of
SERS-active nanoparticles in diagnostics and imaging