20 research outputs found

    Development and application of the heat pulse method for soil physical measurements

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    Accurate and continuous measurements of soil thermal and hydraulic properties are required for environmental, Earth and planetary science, and engineering applications, but they are not practically obtained by steady‐state methods. The heat pulse (HP) method is a transient method for determination of soil thermal properties and a wide range of other physical properties in laboratory and field conditions. The HP method is based on the line‐heat source solution of the radial heat flow equation. This literature review begins with a discussion of the evolution of the HP method and related applications, followed by the principal theories, data interpretation methods, and their differences. Important factors for HP probe construction are presented. The properties determined in unfrozen and frozen soils are discussed, followed by a discussion of limitations and perspectives for the application of this method. The paper closes with a brief overview of future needs and opportunities for further development and application of the HP method

    Broadband CPW-based impedance-transformed Josephson parametric amplifier

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    Quantum-limited Josephson parametric amplifiers play a pivotal role in advancing the field of circuit quantum electrodynamics by enabling the fast and high-fidelity measurement of weak microwave signals. Therefore, it is necessary to develop robust parametric amplifiers with low noise, broad bandwidth, and reduced design complexity for microwave detection. However, current broadband parametric amplifiers either have degraded noise performance or rely on complex designs. Here, we present a device based on the broadband impedance-transformed Josephson parametric amplifier (IMPA) that integrates a horn-like coplanar waveguide (CPW) transmission line, which significantly decreases the design and fabrication complexity, while keeping comparable performance. The device shows an instantaneous bandwidth of 700(200) MHz for 15(20) dB gain with an average saturation power of -110 dBm and near quantum-limited added noise. The operating frequency can be tuned over 1.4 GHz using an external flux bias. We further demonstrate the negligible back-action from our device on a transmon qubit. The amplification performance and simplicity of our device promise its wide adaptation in quantum metrology, quantum communication, and quantum information processing.Comment: 11 pages, 8 figure

    Inflammatory factors and risk of meningiomas: a bidirectional mendelian-randomization study

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    BackgroundMeningiomas are one of the most common intracranial tumors, and the current understanding of meningioma pathology is still incomplete. Inflammatory factors play an important role in the pathophysiology of meningioma, but the causal relationship between inflammatory factors and meningioma is still unclear.MethodMendelian randomization (MR) is an effective statistical method for reducing bias based on whole genome sequencing data. It’s a simple but powerful framework, that uses genetics to study aspects of human biology. Modern methods of MR make the process more robust by exploiting the many genetic variants that may exist for a given hypothesis. In this paper, MR is applied to understand the causal relationship between exposure and disease outcome.ResultsThis research presents a comprehensive MR study to study the association of genetic inflammatory cytokines with meningioma. Based on the results of our MR analysis, which examines 41 cytokines in the largest GWAS datasets available, we were able to draw the relatively more reliable conclusion that elevated levels of circulating TNF-β, CXCL1, and lower levels of IL-9 were suggestive associated with a higher risk of meningioma. Moreover, Meningiomas could cause lower levels of interleukin-16 and higher levels of CXCL10 in the blood.ConclusionThese findings suggest that TNF-β, CXCL1, and IL-9 play an important role in the development of meningiomas. Meningiomas also affect the expression of cytokines such as IL-16 and CXCL10. Further studies are needed to determine whether these biomarkers can be used to prevent or treat meningiomas

    Ongoing evolution of response assessment in glioma: Where do we stand?

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    The investigation and development of recently introduced agents or radiological measurements caused emergent misunderstandings to the response assessment of glioma. To date, the classical Macdonald criteria and the response assessment of neuro-oncology (RANO) criteria have been used successively for the evaluation of glioma outcome. However, ongoing efforts on complementary assessments are necessary to combat this malignancy. In this review, we highlight the shortcomings of the current criteria and introduce the initiative effort of RANO guideline and its offspring. We also discuss some future barriers for accurate assessment of treatment response in glioma

    An in situ real time probe spacing correction method for multi-needle heat pulse sap flow sensors

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    Probe spacing of sap flow sensors affects the quantification of sap flow in plants. The assumption of nocturnal zero flow conditions, required by most non-destructive methods for probe spacing calibration, is often invalid in natural biological systems and extremely hard to validate with in situ measurements. Our study aims to present a novel method for accurate in situ determination of probe spacing. The method uses nonlinear curve fitting with two mathematical models applied during low flow conditions. Numerical simulations were conducted with three types of probe misalignment and demonstrated that errors in heat pulse velocity (V-h) (< 2.0%) is less than the error associated with commonly-used probe spacing correction methods. Field experiment on European beech (Fagus sylvatica L.) comparisons with corrected probe spacing applied to the heat ratio (HR) and Sapflow+ method produced improved sap flux densities, with both methods agreeing very well (root mean square deviation < 1 cm(3) cm(-2) h(-1)). The proposed method allows real time probe spacing measurements at low flow rates, alleviating some uncertainties associated with zero flow assumption. The new method can hence successfully be used to estimate in situ probe spacing for operational measurements of sap flux density

    Measurement of low sap flux density in plants using the single needle heat pulse probe

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    Heat pulse probes are used worldwide to quantify sap flow in plants. Probes consisting of a single needle inserted into a plant have a simple physical configuration relative to multi-probe methods. The single probe also minimizes physical damage to plant tissue. Single probe methods are therefore increasingly used for sap flux density measurements. However, at low sap flux density values, existing single probe heat pulse (SPHP) methods cannot be used for accurate measurements. To increase the sensitivity of SPHP to low sap flux densities, this paper describes and validates a simplified expression of sap flow and heat transport under various heat inputs and finite heat pulse time intervals. To test this theoretical development, measurements were collected from SPHP probes inserted into mature poplar forest trees (Populus tomentosa Carriere) during the 2020 growing season. The results show that the new method can successfully monitor low sap flux density: the lowest measured heat pulse velocity was 3 cm h(-1), which is an improvement from the original SPHP method (20 cm h(-1)). The improved SPHP method had a root mean square deviation (RMSD) of 1.63 cm h(-1) in comparison with the heat ratio (HR) method. The proposed SPHP method is therefore suitable for quantifying both low and high sap flux densities

    Comparing dual heat pulse methods with Peclet's number as universal switch to measure sap flow across a wide range

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    Accurate determination of sap flow over a wide measurement range is important for assessing tree transpiration. However, this is difficult to achieve by using a single heat pulse method. Recent attempts have been made to combine multiple heat pulse methods and have successfully increased the sap flow measurement range. However, relative performance of different dual methods has not yet been addressed, and selection of the numerical threshold used to switch between methods has not been verified among different dual methods. This paper evaluates three different dual methods with respect to measurement range, precision and sources of uncertainty: (method 1) the heat ratio (HR) and compensation heat pulse method; (method 2) the HR and T-max method; and (method 3) the HR and double ratio method. Field experiments showed that methods 1, 2 with three needles and 3 compare well with the benchmark Sapflow+ method, having root mean square deviations of 4.7 cm h(-1), 3.0 cm h(-1) and 2.4 cm h(-1), respectively. The three dual methods are equivalent in accuracy (P > 0.05). Moreover, all dual methods can satisfactorily measure reverse, low and medium heat pulse velocities. However, for high velocities (>100 cm h(-1)), the HR + T-max (method 2) performed better than the other methods. Another advantage is that this method has a three- instead of four-needle probe configuration, making it less error prone to probe misalignment and plant wounding. All dual methods in this study use the HR method for calculating low to medium flow and a different method for calculating high flow. The optimal threshold for switching from HR to another method is HR's maximum flow, which can be accurately determined from the Peclet number. This study therefore provides guidance for an optimal selection of methods for quantification of sap flow over a wide measurement range

    Development and application of the heat pulse method for soil physical measurements

    No full text
    Accurate and continuous measurements of soil thermal and hydraulic properties are required for environmental, Earth and planetary science, and engineering applications, but they are not practically obtained by steady‐state methods. The heat pulse (HP) method is a transient method for determination of soil thermal properties and a wide range of other physical properties in laboratory and field conditions. The HP method is based on the line‐heat source solution of the radial heat flow equation. This literature review begins with a discussion of the evolution of the HP method and related applications, followed by the principal theories, data interpretation methods, and their differences. Important factors for HP probe construction are presented. The properties determined in unfrozen and frozen soils are discussed, followed by a discussion of limitations and perspectives for the application of this method. The paper closes with a brief overview of future needs and opportunities for further development and application of the HP method.This is an article published as He, Hailong, Miles F. Dyck, Robert Horton, Tusheng Ren, Keith L. Bristow, Jialong Lv, and Bingcheng Si. "Development and application of the heat pulse method for soil physical measurements." Reviews of Geophysics 54 (2018): 567-620. doi: 10.1029/2017RG000584. Posted with permission.</p

    Broadband coplanar-waveguide-based impedance-transformed Josephson parametric amplifier

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    Quantum-limited Josephson parametric amplifiers play a pivotal role in advancing the field of circuit quantum electrodynamics by enabling the fast and high-fidelity measurement of weak microwave signals. Therefore, it is necessary to develop robust parametric amplifiers with low noise, broad bandwidth, and reduced design complexity for microwave detection. However, current broadband parametric amplifiers either have degraded noise performance or rely on complex designs. Here, we present a device based on the broadband impedance-transformed Josephson parametric amplifier that integrates a hornlike coplanar waveguide transmission line, which significantly decreases the design and fabrication complexity while keeping comparable performance. The device shows an instantaneous bandwidth of 700 (200) MHz for 15 (20) dB gain with an average input saturation power of −110 dBm and near quantum-limited added noise. The operating frequency can be tuned over 1.4 GHz using an external flux bias. We further demonstrate the negligible backaction from our device on a transmon qubit. The amplification performance and simplicity of our device promise its wide adaptation in quantum metrology, quantum communication, and quantum information processing
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