1 research outputs found
Yeast β‑Glucan Suppresses the Chronic Inflammation and Improves the Microenvironment in Adipose Tissues of ob/ob Mice
Inflammation
in visceral adipose tissues (VATs) contributes to
the pathology of diabetes. This study focused on the inflammatory
regulation in VATs by a yeast β-1,3-glucan (BYG) orally administered
to ob/ob mice. BYG decreased pro-inflammatory modulators of TNF-α,
IL-6, IL-1β, CCL2, and <i>SAA3</i>, and increased
anti-inflammatory factors of <i>Azgp1</i> (2.53 ± 0.02-fold
change) at protein and/or mRNA levels (<i>p</i> < 0.05).
Remarkably, BYG decreased the degree of adipose tissue macrophages
(ATMs) infiltration to 82.5 ± 8.3%, especially the newly recruited
ATMs. Interestingly, BYG increased the protective Th2 cell regulator <i>GATA3</i> (7.72 ± 0.04-fold change) and decreased immunosuppressors <i>IL-10</i> and IL-1ra, suggesting that BYG elicited inflammation
inhibition via stimulating immune responses. Additionally, BYG increased
the gut microbiota proportion of <i>Akkermansia</i> from
0.07% to 4.85% and improved the microenvironment of VATs through decreasing
fibrosis and angiogenesis. These findings suggest that BYG has anti-inflammatory
effect in diabetic mice, which can be used as a food component and/or
therapeutic agent for diabetes