Trend-TDT – a transmission/disequilibrium based association test on functional mini/microsatellites-1

<p><b>Copyright information:</b></p><p>Taken from "Trend-TDT – a transmission/disequilibrium based association test on functional mini/microsatellites"</p><p>http://www.biomedcentral.com/1471-2156/8/75</p><p>BMC Genetics 2007;8():75-75.</p><p>Published online 1 Nov 2007</p><p>PMCID:PMC2180177.</p><p></p> Number of alleles are 4, 6 and 10, respectively

Trend-TDT – a transmission/disequilibrium based association test on functional mini/microsatellites-5

<p><b>Copyright information:</b></p><p>Taken from "Trend-TDT – a transmission/disequilibrium based association test on functional mini/microsatellites"</p><p>http://www.biomedcentral.com/1471-2156/8/75</p><p>BMC Genetics 2007;8():75-75.</p><p>Published online 1 Nov 2007</p><p>PMCID:PMC2180177.</p><p></p>alculated p value is equal to or less than the expected p value, in minus logarithm scale. The line "TRUE" is the expected curve for a correct test, which should be exactly the line "y = x"

Trend-TDT – a transmission/disequilibrium based association test on functional mini/microsatellites-3

<p><b>Copyright information:</b></p><p>Taken from "Trend-TDT – a transmission/disequilibrium based association test on functional mini/microsatellites"</p><p>http://www.biomedcentral.com/1471-2156/8/75</p><p>BMC Genetics 2007;8():75-75.</p><p>Published online 1 Nov 2007</p><p>PMCID:PMC2180177.</p><p></p>e with higher risk (Table 2). Number of alleles is set to 6, with equal allele frequencies, i.e. F6.eq in Table 2. "TDT_L/S" is the TDTmethod using medium allele length as threshold, "TDT_L/S_kn" is the TDTmethod when the threshold is known and is used in the test. Power is calculated from 10,000 simulations on 150 trios, using significant criteria 0.001

Trend-TDT – a transmission/disequilibrium based association test on functional mini/microsatellites-4

<p><b>Copyright information:</b></p><p>Taken from "Trend-TDT – a transmission/disequilibrium based association test on functional mini/microsatellites"</p><p>http://www.biomedcentral.com/1471-2156/8/75</p><p>BMC Genetics 2007;8():75-75.</p><p>Published online 1 Nov 2007</p><p>PMCID:PMC2180177.</p><p></p

Trend-TDT – a transmission/disequilibrium based association test on functional mini/microsatellites-0

<p><b>Copyright information:</b></p><p>Taken from "Trend-TDT – a transmission/disequilibrium based association test on functional mini/microsatellites"</p><p>http://www.biomedcentral.com/1471-2156/8/75</p><p>BMC Genetics 2007;8():75-75.</p><p>Published online 1 Nov 2007</p><p>PMCID:PMC2180177.</p><p></p>alculated p value is equal to or less than the expected p value, in minus logarithm scale. The line "TRUE" is the expected curve for a correct test, which should be exactly the line "y = x"

Psoriasis risk conferred by the three MHC loci in the GAIN dataset.

a<p>‘+’ denotes genotype CT/TT (presence of the risk allele T);</p>b<p>‘+’ denotes genotype AA (absence of the protective allele G).</p

Comparison of the imputed <i>HLA-C</i> genotypes with true genotypes.

<p>Comparison of the imputed <i>HLA-C</i> genotypes with true genotypes.</p

Association of MHC SNPs with psoriasis.

<p>(A) Trend test of MHC SNPs in the GAIN dataset; (B) Logistic regression adjusted for <i>HLA-Cw*0602</i> in the GAIN dataset; (C) Logistic regression adjusted for <i>HLA-Cw*0602</i> and rs2073048 in the GAIN dataset. (D) Logistic regression adjusted for <i>HLA-Cw*0602</i> in the Chinese dataset; (E) Logistic regression adjusted for <i>HLA-Cw*0602</i> and rs28732201 in the Chinese dataset. The red lines indicate the significance level by Bonferroni correction for the number of SNPs tested. The numbers of SNPs are 1593, 1593, 1591, 226, and 252 for (A–E), respectively.</p