Discovery of 21 New Changing-look AGNs in Northern Sky

The rare case of changing-look (CL) AGNs, with the appearance or disappearance of broad Balmer emission lines within a few years, challenges our understanding of the AGN unified model. We present a sample of 21 new CL AGNs at $0.08<z<0.58$, which doubles the number of such objects known to date. These new CL AGNs were discovered by several ways, from (1) repeat spectra in the SDSS, (2) repeat spectra in the Large Sky Area Multi-Object Fiber Spectroscopic Telescope (LAMOST) and SDSS, and (3) photometric variability and new spectroscopic observations. We use the photometric data from surveys, including the SDSS imaging survey, the Pan-STARRS1, the DESI Legacy imaging survey, the Wide-field Infrared Survey Explorer (WISE), the Catalina Real-time Transient Survey, and the Palomar Transient Factory. The estimated upper limits of transition timescale of the CL AGNs in this sample spans from 0.9 to 13 years in the rest frame. The continuum flux in the optical and mid-infrared becomes brighter when the CL AGNs turn on, or vice versa. Variations of more than 0.2 mag in $W1$ band were detected in 15 CL AGNs during the transition. The optical and mid-infrared variability is not consistent with the scenario of variable obscuration in 10 CL AGNs at more than $3\sigma$ confidence level. We confirm a bluer-when-brighter trend in the optical. However, the mid-infrared WISE colors $W1-W2$ become redder when the objects become brighter in the $W1$ band, possibly due to a stronger hot dust contribution in the $W2$ band when the AGN activity becomes stronger. The physical mechanism of type transition is important for understanding the evolution of AGNs.Comment: Accepted for publication in Ap

An Unusual Mid-infrared Flare in a Type 2 AGN: An Obscured Turning-on AGN or Tidal Disruption Event?

We report the discovery of an exceptional MIR flare in a Type 2 AGN, SDSS J165726.81+234528.1, at z = 0.059. This object brightened by 3 mag in the Wide-field Infrared Survey Explorer (WISE) W1 and W2 bands between 2015 and 2017 (and has been fading since 2018), without significant changes (≾0.2 mag) in the optical over the same period of time. Based on the WISE light curves and near-IR imaging, the flare is more significant at longer wavelengths, suggesting an origin of hot dust emission. The estimated black hole mass (~10^(6.5) M⊙) from different methods places its peak bolometric luminosity around the Eddington limit. The high luminosity of the MIR flare and its multiyear timescale suggest that it most likely originated from reprocessed dust radiation in an extended torus surrounding the AGN, instead of from stellar explosions. The MIR color variability is consistent with known changing-look AGN and tidal disruption events (TDEs), but inconsistent with normal supernovae. We suggest that it is a turning-on Type 2 AGN or TDE, where the optical variability is obscured by the dust torus during the transition. This MIR flare event reveals a population of dramatic nuclear transients that are missed in the optical

Microbead-Based Platform for Multiplex Detection of DNA and Protein

We present a novel microbead-based detection platform as a simple and universal strategy for simultaneous determination of multiple biomolecules. This platform is composed of streptavidin coated uniform-sized polystyrene microbeads, dye and biotin-labeled ssDNA or aptamer probes, and quencher-labeled complementary sequences. By this method, upon target binding to the probes, quencher strand dissociation is triggered, which results in fluorescence reactivation of the microbead linked probes. The fluorescence variation is readily monitored by flow cytometry and with a high sensitivity. Explicitly, this microbead-based detection platform shows a high sensitivity for target DNA with a detection limit as low as 0.20 nM, alongside good selectivity from one-base mismatched DNA. This novel platform also shows good selectivity and high sensitivity for protein detection when aptamer is used as a probe. The detection limit for lysozyme is as low as 8.56 nM. Moreover, simultaneous detection of multiple targets has been achieved via incorporating different dye-labeled probes on the microbeads concurrently. We have also applied this developed strategy to the detection of target DNA in human serum. This strategy can be easily extended to other targets through simple probe and quencher variation

A DNA Aptameric Ligand of Human Transferrin Receptor Generated by Cell-SELEX

General cancer-targeted ligands that can deliver drugs to cells have been given considerable attention. In this paper, a high-affinity DNA aptamer (HG1) generally binding to human tumor cells was evolved by cell-SELEX, and was further optimized to have 35 deoxynucleotides (HG1-9). Aptamer HG1-9 could be taken up by live cells, and its target protein on a cell was identified to be human transferrin receptor (TfR). As a man-made ligand of TfR, aptamer HG1-9 was demonstrated to bind at the same site of human TfR as transferrin with comparable binding affinity, and was proved to cross the epithelium barrier through transferrin receptor-mediated transcytosis. These results suggest that aptamer HG1-9 holds potential as a promising ligand to develop general cancer-targeted diagnostics and therapeutics

Adaptive Single Photon Compressed Imaging Based on Constructing a Smart Threshold Matrix

We demonstrate a single-photon compressed imaging system based on single photon counting technology and compressed sensing theory. In order to cut down the measurement times and shorten the imaging time, a fast and efficient adaptive sampling method, suited for single-photon compressed imaging, is proposed. First, the pre-measured rough images are transformed into sparse bases as a priori information. Then a smart threshold matrix is designed by using large sparse coefficients of the rough image in sparse bases. The adaptive measurement matrix is obtained by modifying the original Gaussian random matrix with the specially designed threshold matrix. Building the adaptive measurement matrix requires only one level of sparse representation, which means that adaptive imaging can be achieved quickly with very little computation. The experimental results show that the reconstruction effect of the image measured using the adaptive measurement matrix is obviously superior than that of the Gaussian random matrix under different measurement times and different reconstruction algorithms

Modeling and Testing of a Composite Steel–Concrete Joint for Hybrid Girder Bridges

A hybrid girder bridge adopts a steel segment at the mid-span of the main span of a continuous concrete girder bridge. The critical point of the hybrid solution is the transition zone, connecting the steel and concrete segments of the beam. Although many girder tests revealing the structural behavior of hybrid girders have been conducted by previous studies, few specimens took the full section of a steel–concrete joint due to the large size of prototype hybrid bridges. In this study, a static load test on a composite segment to bridge the joint between the concrete and steel parts of a hybrid bridge with full section was conducted. A finite element model replicating the tested specimen results was established through Abaqus, while parametric studies were also conducted. The test and numerical results revealed that the concrete filling in the composite solution prevented the steel flange from extensive buckling, which significantly improved the load-carrying capacity of the steel–concrete joint. Meanwhile, strengthening the interaction between the steel and concrete helps to prevent the interlayer slip and simultaneously contributes to a higher flexural stiffness. These results are an important basis for establishing a rational design scheme for the steel–concrete joint of hybrid girder bridges