70 research outputs found

    A mouse line for inducible and reversible silencing of specific neurons

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    This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. Acknowledgements: We thank Dr. Joseph W. Lynch for sharing the IVMR plasmid, and Dr. Lisa M. Monteggia for sharing the AAV2-Cre plasmid. Rosa-CAG targeting vector was obtained from Addgenes. This work was supported by the Key State Research Program from Ministry of Science and Technology of China (2011CB510005, 2012CB966900, 2013CB835103), National Natural Science Foundation of China (81221001, 81200692, 81101026, 31100788, 31271182, 31030034, 91232724), Science and Technology Commission of Shanghai Municipality (12XD1404800), Shanghai Pujiang Program (12PJ1408800), Key Disciplines Group Construction Project of Pudong Health Bureau of Shanghai (PWZxq2014-04) and Sino-UK Higher Education Research Partnership for PhD Studies.Peer reviewedPublisher PD

    Mobile Landmark Search with 3D Models

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    Recent advances in social multimedia big data mining and applications

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    DE-net: Dynamic Text-Guided Image Editing Adversarial Networks

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    Text-guided image editing models have shown remarkable results. However, there remain two problems. First, they employ fixed manipulation modules for various editing requirements (e.g., color changing, texture changing, content adding and removing), which results in over-editing or insufficient editing. Second, they do not clearly distinguish between text-required and text-irrelevant parts, which leads to inaccurate editing. To solve these limitations, we propose: (i) a Dynamic Editing Block (DEBlock) that composes different editing modules dynamically for various editing requirements. (ii) a Composition Predictor (Comp-Pred), which predicts the composition weights for DEBlock according to the inference on target texts and source images. (iii) a Dynamic text-adaptive Convolution Block (DCBlock) that queries source image features to distinguish text-required parts and text-irrelevant parts. Extensive experiments demonstrate that our DE-Net achieves excellent performance and manipulates source images more correctly and accurately

    You Are What You Eat: Exploring Rich Recipe Information for Cross-Region Food Analysis

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    Comparative study on two different operations of high myopia

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    AIM: To evaluate the safety, efficacy and stability of posterior chamber phakic intraocular lens(ICL)implanation and clear lens extraction for the correction of high myopia. METHODS: The study enrolled 56 cases(100 eyes)of high myopia. Group I comprised 32 cases(58 eyes)receiving ICL implantation and Group II comprised 24 cases(42 eyes)undergoing clear lens extraction. In this study, we evaluated the two groups of subject's the visual and refractive results, intraocular pressure(IOP), endothelial cell density(ECD), anterior chamber depth(ACD), lens transparency, the surgical complications as well as visual adverse symptoms before and after surgery.RESULTS: The postoperative subjects in group I and group II were followed, uncorrected vision acuity(UCVA)>0.5 were 69.0% in group I and 71.4% in group II after 3mo. UCVA>0.5 were 72.4% in group I and 73.8% in group II after 1a. Predictability of the manifest spherical equivalent refraction within Ā±1.00D was achieved in 62.1% of eyes in group I and 57.1% in group II after 1a. The central vault of the ICL(distance from posterior surface of ICL to the crystalline lens)measured with anterior segment optical coherence tomography(AS-OCT)was 0.35-0.54(0.40Ā±0.16)mm. Twelve point one percent of eyes in group I and 7.1% of eyes in group II had transient mild increase in IOP. Here were statistically significant differences between preoperative and postoperative ECD(PCONCLUSION: ICL implantation and clear lens extraction are effective, safe and predictable surgical option for the management of high myopia. No severe complications occurred, but its long time effect and safety still need more time to prove
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