36 research outputs found
Asymmetric Construction of Spirocyclopentenebenzofuranone Core Structures via Highly Selective Phosphine-Catalyzed [3 + 2] Cycloaddition Reactions
An efficient organocatalytic asymmetric [3 + 2] cycloaddition reaction between 3-substituted methylenebenzofuranone derivatives and diverse MoritaâBaylisâHillman carbonates to provide complex polysubstituted spirocyclopentenebenzofuranone scaffolds in a single step is reported. C2-symmetric phospholanes were efficient nucleophilic catalysts of this transformation under mild conditions, providing reaction products comprised of three consecutive stereocenters, including one all-carbon center, with excellent enantioselectivity
Organocatalysis as a Safe Practical Method for the Stereospecific Dibromination of Unsaturated Compounds
Organocatalytic stereospecific dibromination of a wide variety of functionalized alkenes was achieved using a stable, inexpensive halogen source, 1,3-dibromo 5,5-dimethylhydantoin, and a simple thiourea catalyst at room temperature. The presence of a tertiary amine enhanced the rate of the dibromination reaction, and yields were good in various solvents, including aqueous solvents. The procedure was extended to alkynes and aromatic rings and to dichlorination reactions by using the 1,3-dichloro hydantoin derivative
Assembly of Spirooxindole Derivatives Containing Four Consecutive Stereocenters via Organocatalytic MichaelâHenry Cascade Reactions
A novel organocatalytic strategy for the synthesis of highly substituted spirocyclopentaneoxindoles was developed employing simple nitrostyrenes and 3-substituted oxindoles as starting materials. MichaelâHenry cascade reactions, enabled through cinchona alkaloid organocatalysis, provided products in high yield and excellent enantioselectivity in a single step
Organocatalysis as a Safe Practical Method for the Stereospecific Dibromination of Unsaturated Compounds
Organocatalytic stereospecific dibromination of a wide variety of functionalized alkenes was achieved using a stable, inexpensive halogen source, 1,3-dibromo 5,5-dimethylhydantoin, and a simple thiourea catalyst at room temperature. The presence of a tertiary amine enhanced the rate of the dibromination reaction, and yields were good in various solvents, including aqueous solvents. The procedure was extended to alkynes and aromatic rings and to dichlorination reactions by using the 1,3-dichloro hydantoin derivative
Alkene Trifluoromethylation-Initiated Remote αâAzidation of Carbonyl Compounds toward Trifluoromethyl ÎłâLactam and Spirobenzofuranone-Lactam
The
first unprecedented one-pot domino strategy toward diverse
CF<sub>3</sub>-containing Îł-lactam and spirobenzofuranone-lactam
scaffolds of antibacterial armeniaspirole from readily available acyclic
precursors was developed. The key point of this transformation was
the concurrent incorporation of CF<sub>3</sub> and azide into the
alkene and remote carbonyl
α-CâH position via carbonyl-stabilized radical intermediate
triggered by alkene trifluoromethylation via a 1,5-H shift in a highly
controlled site-selective manner. Furthermore, gram-scale synthesis
and synthetic applicability of these compounds proved suitable
Metal-Free Direct 1,6- and 1,2-Difunctionalization Triggered by Radical Trifluoromethylation of Alkenes
A metal-free direct remote CâH
functionalization triggered
by radical trifluoromethylation of alkenes was explored, realizing
highly selective 1,6-difunctionalization of alkenes toward valuable
trifluoromethyl α-hydroxycarbonyl compounds. Furthermore, a
metal-free direct intermolecular regioselective 1,2-oxytrifluoromethylation
of alkenes is also disclosed. With Togniâs reagent as both
the CF<sub>3</sub> source and oxidant, the reaction exhibits a broad
substrate scope with excellent functionality tolerance under mild
metal-free conditions, thus showing great potential for synthetic
utility
Metal-Free Direct 1,6- and 1,2-Difunctionalization Triggered by Radical Trifluoromethylation of Alkenes
A metal-free direct remote CâH
functionalization triggered
by radical trifluoromethylation of alkenes was explored, realizing
highly selective 1,6-difunctionalization of alkenes toward valuable
trifluoromethyl α-hydroxycarbonyl compounds. Furthermore, a
metal-free direct intermolecular regioselective 1,2-oxytrifluoromethylation
of alkenes is also disclosed. With Togniâs reagent as both
the CF<sub>3</sub> source and oxidant, the reaction exhibits a broad
substrate scope with excellent functionality tolerance under mild
metal-free conditions, thus showing great potential for synthetic
utility
Highly Atroposelective Synthesis of Arylpyrroles by Catalytic Asymmetric PaalâKnorr Reaction
A general
and efficient method for accessing enantiomerically pure
arylpyrroles by utilizing the catalytic asymmetric Paal-Knorr reaction
has been developed for the first time. A wide range of axially chiral
arylpyrroles were obtained in high yields with good to excellent enantioselectivities.
The key to success is the use of the combined-acid catalytic system
involving a Lewis acid and a chiral phosphoric acid for achieving
effective enantiocontrol. Noteworthy is that an unexpected solvent-dependent
inversion of the enantioselectivity was observed in the above-mentioned
asymmetric reaction
Enantioselective Synthesis of Chiral Cyclobutenes Enabled by BrĂžnsted Acid-Catalyzed Isomerization of BCBs
Chiral cyclobutene units are commonly found in natural
products
and biologically active molecules. Transition-metal-catalysis has
been extensively used in asymmetric synthesis of such structures,
while organocatalytic approaches remain elusive. In this study, bicyclo[1.1.0]Âbutanes
are involved in enantioselective transformation for the first time
to offer a highly efficient route toward cyclobutenes with good regio-
and enantiocontrol. The utilization of N-triflyl
phosphoramide as a chiral BrĂžnsted acid promoter enables this
isomerization process to proceed under mild conditions with low catalyst
loading as well as good functional group compatibility. The resulting
chiral cyclobutenes could serve as platform molecules for downstream
manipulations with excellent reservation of stereochemical integrity,
demonstrating the synthetic practicality of the developed method.
Control experiments have also been performed to verify the formation
of a key carbocation intermediate at the benzylic position
Data_Sheet_1_Distribution pattern of endophytic bacteria and fungi in tea plants.docx
Endophytes are critical for plant growth and health. Tea is an economically important crop in China. However, little is known about the distribution pattern and potential functions of endophytic communities in tea trees. In this study, two genotypes (BXZ and MF) cultivated under the same conditions were selected, and endophytic bacteria and fungi were analyzed through 16S rRNA and ITS high-throughput sequencing technologies, respectively. For endophytic bacteria, root tissues harbored the most diverse endophytes, followed by stems and old leaves, and new leaves possessed the lowest diversity. In contrast, old leave tissues harbored more diverse endophytic fungi than did root and stem tissues. Most of the dominant endophytes showed obvious cultivar and tissue preferences. Tissue type played a more important role in shaping community structure than did cultivar. Nevertheless, some endophytic bacterial groups, which mainly affiliated to Chryseobacterium, Sphingomonas, Rhizobium, Morganella, Methylobacterium and Comamonadaceae, could parasitize different tissues, and the average relative abundance of endophytic bacteria was as high as 72.57%. Some endophytic fungal populations, such as Colletotrichum, Uwebraunia, Cladosporium, and Devriesia, could also parasitize tea, and the relative abundance accounted for approximately 25.70â97.26%. The cooperative relationship between endophytic bacteria and fungi in the new leaves was stronger than that in the old leaves, which can better participate in the metabolism of tea material.</p