The town of Limestone is preparing for the second weekend concert, dubbed Lemon

The town of Limestone is preparing for the second weekend concert, dubbed Lemonwheel, of the Vermont-based band Phish. The Great Went concert last year brought nearly 70,000 people to the area and an estimated $20 to$30 million into the state economy. The townspeople praised the behavior of concertgoers last year, and this year stores are fine-tuning their stocks to accommodate tastes of the fans. The concerts taken place at the former Loring Air Force Base

Development of the Paris definition of early Crohn's disease for disease-modification trials: results of an international expert opinion process.

We report the findings and outputs of an international expert opinion process to develop a definition of early Crohn's disease (CD) that could be used in future disease-modification trials. Nineteen experts on inflammatory bowel diseases held an international expert opinion meeting to discuss and agree on a definition for early CD to be used in disease-modification trials. The process included literature searches for the relevant basic-science and clinical evidence. A published preliminary definition of early CD was used as the basis for development of a proposed definition that was discussed at the expert opinion meeting. The participants then derived a final definition, based on best current knowledge, that it is hoped will be of practical use in disease-modification trials in CD