9 research outputs found
Hypermethylation of p15 Gene in Diffuse - Large B-Cell Lymphoma: Association with Less Aggressiveness of the Disease
In this study, methylation-specific polymerase chain reaction was used to investigate the potential prognostic significance of the methylation status of p15, p16, MGMT, and DAPK genes in 51 specimens of diffuse large B-cell lymphoma (DLBCL). Hypermethylation of p15 gene was significantly more prevalent in patients without relapse (p = 0.001) and there was a trend toward more frequent presence of p15 methylation in patients without death outcome within 5-year follow-up period (p = 0.086) Also, there was a trend toward accumulation of p15 methylation with favorable clinicopathological parameters including: age 60 years (p = 0.091), normal levels of lactate dehydrogenase (p = 0.090), Eastern Cooperative Oncology Group performance status LT 2 (p = 0.095), and low/intermediate low International Prognostic Index (p = 0.076). In the female group and group of the patients without bulky tumor mass, treated with chemotherapeutic regimens including rituximab, methylation of p15 was significantly related to longer overall survival (p = 0.036 and 0.027, respectively). Our results suggest that promoter methylation of p15 gene could have prognostic value in DLBCL patients treated with rituximab when used in combination with gender and tumor size
Relation of CuZnSOD activity with renal insufficiency in hypertensive diabetic patients
97-100Diabetes and
renal insufficiency are interrelated metabolic disorders closely associated
with redox homeostasis disturbances. The aim of this study was to compare the
activity of copper zinc superoxide dismutase (CuZnSOD) in the erythrocytes of
hypertensive diabetic patients with or without renal insufficiency with normal
healthy control subjects. In both groups of diabetic patients, blood glucose
level and the content of glycosylated hemoglobin (HbA1c) were higher
than in the control group. However, CuZnSOD activity was significantly higher
than control only in hypertensive diabetic patients with renal insufficiency.
Our results suggest that disturbances in superoxide homeostasis do correlate
with long-term complication in diabetes, i.e. diabetic renal insufficiency and
hypertension
Splenectomy with chemotherapy vs surgery alone as initial treatment for splenic marginal zone lymphoma
AIM: To evaluate the clinical characteristics of splenic marginal-zone lymphoma (SMZL) following antigen expression and the influence of therapeutic approaches on clinical outcome and overall survival (OS)