4 research outputs found
Representation of CYP3A4, CYP3A5 and UGT1A4 Polymorphisms within Croatian Breast Cancer Patients’ Population
- Author
- Publication venue
- 'MDPI AG'
- Publication date
- 23/05/2020
- Field of study
Single nucleotide polymorphism (SNP) in genes encoding drug-metabolizing enzymes (DME) could have a critical role in individual responses to anastrozole. Frequency of CYP3A4*1B, CYP3A5*3 and UGT1A4*2 SNPs in 126 Croatian breast cancer (BC) patients and possible association with anastrozole-induced undesirable side effects were analyzed. Eighty-two postmenopausal patients with estrogen receptor (ER)-positive BC treated with anastrozole and 44 postmenopausal ER-positive BC patients before hormonal adjuvant therapy were included in the study. Genomic DNA was genotyped by TaqMan Real-Time PCR. Bone mineral density (BMD) was measured by dual-energy X-ray absorptiometry. The homozygotes for the variant G allele of CYP3A5*3 were predominant (88%), and the homozygotes for the reference A allele were not detected. While homozygotes for the variant G allele of CYP3A4*1B were not detected, predominantly wild type homozygotes for A allele (94%) were present. CYP3A4*1B and CYP3A5*3 SNPs were in 84.3% linkage disequilibrium (D’ = 0.843) and 95.1% (D’ = 0.951) in group treated with anastrozole and w/o treatment, respectively. Homozygotes for the A allele of UGT1A4*2 were not detected in our study groups. Although the variant CYP3A5*3 allele, which might result in poor metabolizer phenotype and more pronounced side effects, was predominant, significant association with BMD changes induced by anastrozole were not confirmed
Current management of the mangled upper extremity
- Author
- A Foroohar
- A Gupta
- A Moise
- A Seal
- Aleksandar Lesic
- AV Korompilias
- B Faibisoff
- B Graham
- BK Grunert
- BS Lutz
- CJ Lenarz
- D Ring
- DC Campbell 2nd
- DC Covey
- DL McGee
- DR Dirschl
- FC Wei
- G Lister
- G Pino Di
- GA Giessler
- HC Brown
- Henry D. E. Atkinson
- HR Howe Jr
- JB Brown
- JB Jupiter
- JR Slauterbeck
- JT Shores
- K Johansen
- K Okike
- K Peacock
- L Heller
- L Levin
- M Bumbaširević
- M Godina
- M Siemionow
- M Stevanovic
- Marko Bumbasirevic
- MF Stancic
- MG Mcnamara
- Milan Stevanovic
- MJ Bosse
- ML Bernstein
- MW Neumeister
- MW Ricci
- N Vedder
- PW Brown
- R Bilic
- RA Bueno Jr
- RA Weber
- RC Russel
- RD Hoffman
- RG Clement
- RH Lange
- RM Durham
- RR Risso
- RT Gregory
- S Stanec
- SE Mackinnon
- SM Tintle
- SW Chan
- T Granchi
- TJ Francel
- TM Meyer
- TS Axelrod
- TS Gorsche
- VE Meyer
- W Burkhalter
- WA Morrison
- WL Russell
- WTY Brown Re
- Z Charalampos
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Post-anaesthesia pulmonary complications after use of muscle relaxants (POPULAR): a multicentre, prospective observational study
- Author
- Abad Gurumeta Alfredo
- Abernethy Caroline
- Abigail Patrick
- Achaibar Kira
- Adam Emily
- Afshari Arash
- Agudelo Montoya María Elizabeth
- Akgün Fatma Nur
- Aletti Gabriele
- Alkış Neslihan
- Allan Ashley
- Allan Katie
- Allaouchiche Bernard
- Allcock Clare
- Almasy Emoke
- Amey Isobel
- Amigoni Maria
- Andersen Elin
- Andersson Peder
- Anipchenko Natalya
- Antunes Pedro
- Armstrong Earlene
- Aslam Tayyba
- Assunção José-Pedro
- Ausserer Julia
- Avvai Mary
- Awad Nahla
- Ayas Montero Begoña
- Ayuso Mercedes
- Azevedo Patricia
- Badarau Victoria
- Badescu Roxana
- Baiardo Redaelli Martina
- Baird Colin
- Baird Yolanda
- Baker Tim
- Balaji Packianathaswamy
- Balan Cristina
- Balandin Alina
- Balescu-Arion Carmen
- Baliuliene Vilda
- Baltasar Isabel Jorge
- Baluch Saif Nasr
- Bandrabur Daniela
- Bankewitz Carla
- Barber Katrina
- Barbera Francesco
- Barcraft-Barnes Helena
- Barletti Valentina
- Barnett Gill
- Baron Kirsty
- Barros Ana
- Barsan Victoria
- Bartlett Pauline
- Batistaki Chrysanthi
- Baumgarten Georg
- Baumüller Eva
- Baytaş Volkan
- Beauchamp Nigel
- Becerra Cayetano Isabel A.
- Bell Stephanie
- Bellandi Mattia
- Belletti Alessandro
- Belmonte Cuenca Julio
- Benitez-Cano Adela
- Beretta Luigi
- Berger Marc Moritz
- Bergmann Nicole
- Bergmark Kristina
- Bermudez Lopez Maria
- Bernotaite Monika
- Beurskens Charlotte
- Bidd Heena
- Bifulco Francesca
- Bignami Elena
- Bilic Aleksandar
- Bilskiene Diana
- Bischoff Petra
- Bishop Luke
- Bjønness Therese
- Blaylock Heather
- Blethyn Kate
- Blincoe Thomas
- Blobner Manfred
- Blobner Manfred
- Blobner Manfred
- Blokhin Ivan
- Blunt Nadia
- Boer Christa
- Bois Grégory
- Bonicolini Eleonora
- Booth Joanna
- Borecka-Kedzierska Miraslawa
- Borstnar Katarina
- Borys Michal
- Boselli Emmanuel
- Bouvet Lionel
- Bouwman Arthur
- Bowen Leonora
- Bowrey Sarah
- Boxall Leigh
- Bozić Teodora
- Bradley Tom
- Branco Teresa
- Brazzi Luca
- Brazzoni Marcella
- Brear Tracy
- Brogly Nicolas
- Brohi Farooq
- Broms Jacob
- Bubliauskas Andrius
- Bucolo Gea Erika
- Buerkle Hartmut
- Buggy Donal
- Buhre Wolfgang F.
- Bukauskas Tomas
- Butturini Francesco
- Byttner Anders
- Cabrera Díaz Itahísa
- Calderon Adriana
- Calhau Ricardo
- Callejo Angel
- Cammu Guy
- Campesato Manuela
- Camsooksai Julie
- Can Özlem Selvi
- Cantor Andreea
- Carise Elsa
- Carmona Cristina
- Carreteiro Joana
- Carrieri Cosima
- Carter Anna
- Casal Manuela
- Casanova Irene
- Cascella Marco
- Casero Luis M.
- Casiraghi Giuseppina Maria
- Castelo-Branco Laila
- Castro Arranz Carlos
- Cernea Daniela
- Cervantes Oriol
- Chandler Ben
- Charnock Robert
- Chatzimicali Aikaterini
- Chervjakov Igor
- Chinery Elaine
- Chishti Ahmad
- Chondhury Priyakam
- Christie Emily
- Christodoudiles George
- Ciardo Stefano
- Cimpeanu Luminata
- Cinnella Gilda
- Cirstea Emanuel
- Clark Sebastian
- Clayton Matthew
- Cocu Simona
- Collyer Thomas
- Colvin Carrie
- Cope Sean
- Copeta Filomena
- Copotoiu Sanda
- Correia de Barros Filinto
- Corso Ruggero Massimo
- Cortegiani Andrea
- Costa Gabriela
- Cowton Amanda
- Cox Nicola
- Craig James
- Cricca Valentina
- Cronin John
- Cunha Mariana
- Cuomo Arturo
- Curley Katherine
- Czuczwar Miroslaw
- Cîndea Iulia
- Dabrowska Dominika
- Damster Sandrine
- Danguy des Déserts Marc
- Daniliuc Aura
- Danninger Thomas
- Darwish Imad
- Dascalu Corina
- Davies Kirsty
- Davies Simon
- De Boer Hans D.
- De Flaviis Adelisa
- De Salut Mar Parc
- de Selincourt Gabrielle
- Deana Cristian
- Debaene Bertrand
- Debreceni Gabor
- Dedhia Jatin
- Delgado Garcia Isabel
- Della Rocca Giorgio
- Delroy-Buelles Ilana
- Desai Tejal
- Dhillon Parveen
- Di Giacinto Ida
- Di Mauro Piero
- Diaz Gomez Tamara V.
- Dimitrovski Aleksandar
- Dinic Vesna
- Divander Mona-Britt
- Dolinar Janez
- Domingues Susana
- Doolan James
- Downes Charlotte
- Dragoescu Alice
- Droc Gabriela
- Dum Elisabeth
- Dumitrescu Alexandra
- Duncan Louise
- Dzurňáková Paula
- Dîrzu Dan-Sebastian
- Eberl Susanne
- Edwards Jayne
- Edwards Mark
- Ekelund Kim
- Ekengren Patrik
- Elghouty Eyad
- Ellerkmann Richard
- Ellis Helen
- Elme Andreas
- Eriksson Lars I
- Eriksson Lars I
- Eriksson Lars I.
- Ernst Thomas
- Errando Carlos Luis
- Esteves Simao
- Ewaldsson Callis
- Farid Nahla
- Featherstone James
- Febres Daniela
- Fedorov Sergey
- Feggeler Johanna
- Feijten Prisca
- Fellmann Tobias
- Fernando Aruna
- Fernández Castineira Adrian
- Fernández-Candil Juan
- Ferrando Carlos
- Ferreira Leonia
- Ferreira Patrick
- Feyling Anders
- Filipescu Daniela
- Fleischer Andreas
- Floris Leda
- Foerster Urs
- Fox Benjamin
- Franke Uwe
- Frasca Denis
- Frey Christian
- Frost Victoria
- Fullin Giorgio
- Fumagalli Jacopo
- Furneval Julie
- Fusari Maurizio
- Gallacher Stuart
- Galushka Svetlana
- Gambale Giorgio
- Gambino Irene
- Garcia-Perez Maria Luisa
- Garg Sanjeev
- Garlak Justyna
- Gavranović Zeljka
- Gavrilov Roman
- Gaynor James
- Gecaj-Gashi Agreta
- Georghiou Maria
- Gerjevic Bozena
- Gferer Gudrun
- Giarratano Antonino
- Gibson Andy
- Gievski Vanja
- Giles Julian
- Gillberg Lars
- Gilowska Katarzyna
- Gilsanz Rodriguez Fernando
- Gioia Antonio
- Giovannoni Cecilia
- Girotra Vandana
- Gkinas Dimitrios
- Gkiokas George
- Godoroja Daniela
- Goebel Ulrich
- Goel Vandana
- Gonzalez Matilde
- Goranović Tatjana
- Gornik-Wlaszczuk Ewa
- Gosavi Smita
- Gottfridsson Peter
- Gottschalk Andre
- Granell Manuel
- Granstrom Anna
- Grassetto Alberto
- Greenwood Anna
- Grigoras Ioana
- Grintescu Ioana
- Gritsan Alexey
- Gritsan Galina
- Grynyuk Andriy
- Guadagnin Giovanni Maria
- Guarnieri Marcello
- Guerrero Diez Maria
- Gunenc Ferim
- Gupta Pawan
- Guttenthaler Vera
- Günther Ulf
- Güçlü Çiğdem
- Hack Yvonne
- Hafisayena Ade
- Hagău Natalia
- Haldar Jagannath
- Hales Dawn
- Hales Dawn
- Hancı Volkan
- Hanna-Jumma Sameer
- Harazim Hana
- Harlet Pierre
- Harper Daniel
- Harris Benjamin
- Harvey Orla
- Hashimi Medita
- Hawkins Lesley
- Hayes Conrad
- Heaton James
- Heier Tom
- Helliwell Laurence
- Hemmes Sabrine
- Henderson Kate
- Hermanides Jeroen
- Hermanns Henning
- Herrera Hueso Berta
- Hestenes Siv
- Hettiarachchi Roshane M
- Highgate Judith
- Hodgson Keith
- Hoeft Andreas
- Hoeft Andreas
- Hoelbling Daniel
- Holland Jonathan
- Hollmann Markus
- Hollmann Markus
- Horhota Lucian
- Hormis Anil
- Hribar Renata
- Hua Alina
- Humphreys Sally
- Humphries Ryan
- Humplíková Simona
- Hunt Jane
- Hunter Jennifer
- Hunter Jennifer
- Hunter Jennifer M
- Husnain Ali
- Hussein Ahmed
- Hyams Benjamin
- Iannuccelli Fabrizio
- Ilett Katie
- Ilyas Carl
- Inan Turgay
- India Inmaculada
- Ionităv Victor
- Irwin Foo
- Jain Vipul
- Janez Benedik
- Jankovic Radmilo
- Jenkins Sarah
- Jenko Matej
- Jimenez Gomez Barbara
- Jimenez Raquel
- Joachim Suganthi
- Joelsson-Alm Eva
- John John
- Jonikaite Lina
- Jonsson Fagerlund Malin
- Jonsson Fagerlund Malin
- Jonsson Fagerlund Malin
- Jovic Miomir
- Junke Etienne
- Kabakov Borys
- Kadaoui Salah-Din
- Kanski Andrzej
- Karadağ Süheyla
- Karbonskiene Aurika
- Karjagin Juri
- Kasnik Darja
- Katanolli Fatos
- Katsika Eleni
- Kaufmann Kai
- Keane Helen
- Kelly Martin
- Kent Melanie
- Keraitiene Grazina
- Khudhur Ahmed
- Khuenl-Brady Karin
- Kidd Laurie
- King Siobhan
- Kirchgäßner Katharina
- Kirmeier Eva
- Kirmeier Eva
- Klancir Tino
- Klucniks Andris
- Knotzer Johann
- Knowlden Peter
- Koers Lena
- Kompan Janez
- Koneti Kiran Kumar
- Kooij Fabian
- Koolen Eric
- Koopman - van Gemert Anna Wilhelmina Margaretha Maria
- Kopp Kristen
- Korfiotis Dimitrios
- Korolkov Oleg
- Kosinová Martina
- Kotzinger Oskar
- Kovačević Marko
- Kranke Eva
- Kranke Peter
- Kraus Christiane
- Kraus Stephanie
- Kubitzek Christiane
- Kucharski Rafal
- Kucukguclu Semih
- Kudrashou Aliaksandr
- Kumar Vinayak
- Kummen Live
- Kunit Cornelia
- Kushakovsky Vlad
- Kuvaki Bahar
- Kuzmanovska Biljana
- Kyttari Aikaterina
- Köstenberger Markus
- Landoni Giovanni
- Lau Gary
- Lazarev Konstantin
- Leggett Samantha
- Legrottaglie Anna Maria
- Leonardi Silvia
- Leong Maria
- Lercher Helene
- Leuvrey Matthieu
- Leva Brigitte
- Levstek Meta
- Lewald Heidrun
- Lewald Heidrun
- Limb James
- Lindholm Espen
- Linton Fiona
- Liperi Corrado
- Lipski Fabian
- Lirk Philipp
- Lisi Alberto
- Lišková Katarina
- Lluch Oltra Aitana
- Loganathan Vinothan
- Lombardi F. Stefania
- Lopez Lopez Eloisa
- Lopez Rodríguez Maria
- Lorenzini Laura
- Lowicka Malgorzata
- Lugovoy Alexander
- Luippold Madeleine
- Lumb Andrew
- López Alvarez Alexo
- López Eliana
- Mac Gregor Mark Gordon
- Macas Andrius
- Machado Humberto
- Maciariello Maria
- Madeira Isabel
- Maitan Stefano
- Majewski Jacek
- Maldini Branka
- Malewski Georgia
- Manfredini Livia
- Marchand Bahareh
- Marcu Alexandra
- Margalef Jordi
- Margarson Michael
- Marinheiro Lucia
- Markić Ana
- Markovič Bozič Jasmina
- Marrazzo Francesco
- Martin Ayuso Maria
- Martin Jane
- Martinez Esther
- Martino Enrico Antonio
- Martinson Victoria
- Marusič-Gaser Katarina
- Mascarenhas Catia
- Mathis Cindy
- Matsota Paraskevi
- Mavrommati Eleni
- Mazul Sunko Branka
- Mccourt Killian
- Mcgill Neil
- Mckee Raymond
- Meier Sonja
- Meistelman Claude
- Meistelman Claude
- Meistelman Claude
- Melbourne Susan
- Melbybråthen Grethe
- Meli Andrea
- Melia Aiden
- Melotti Rita Maria
- Menga Maria Rosaria
- Mercer Pauline
- Merotra Susan
- Mescolini Silvia
- Metterlein Thomas
- Meço Başak Ceyda
- Michalov Martin
- Michlig Sam
- Midgley Susan
- Milić Morena
- Milojevic Milan
- Minto Gary
- Mirabella Lucia
- Mirea Liliana
- Mittelstädt Ludger
- Miñana Amanda
- Moeglen Aude
- Moise Alida
- Mokini Zhirajr
- Molin Anna
- Moltó Luis
- Monea Maria Concetta
- Montalto Francesca
- Montgomery Claire
- Montgomery Jane
- Montillo Gerardo
- Moore Faye
- Moore Sally
- Moreira Zelia
- Moreno Ricardo
- Moreno Tania
- Moret Enrique
- Moreton Sarah
- Morgan Marianne
- Moro Velasco Concepción
- Morri Davide
- Moull Alice
- Moura Fernando
- Mrozek Katarzyna
- Mráz Peter
- Mukhtar Karim
- Muniyappa Sudeshkumar
- Murray Heather
- Murthy Burra V. S.
- Mushambi Mary
- Männer Olja
- Nadolski Maria
- Nardelli Pasquale
- Nardin Giordano
- Navarro Perez Rosalia
- Naveiro Pan Andrea
- Negri Manuela
- Nesek Adam Visnja
- Neskovic Vojislava
- Neuwersch Stefan
- Neves Miriam
- Nguyen Ba Vinh
- Nicholas Caroline
- Nightingale Jeremy
- Norrie Kylie
- Novak-Jankovič Vesna
- Novillo Marta
- Nováková Andrea
- Numan Sandra
- Ní Eochagáin Aisling
- O'Reilly Rosalind
- Oduro-Dominah Louise
- Oldner Anders
- Oliveira Isabel
- Ologoiu Daniela
- Oloktsidou Eirini
- Orlando Alessandro
- Ovezov Alexey
- Ozbilgin Sule
- Paal Peter
- Padin Barreiro Lidia
- Palugniok Ryszard
- Papaioannou Alexandra
- Papapostolou Konstantinos
- Paranthaman Prabhakar
- Pardey Bracho Gilda F
- Parente Suzana
- Parfeni Alexandru
- Pasin Laura
- Passey Samuel
- Pastor Ernesto
- Patch Sarah
- Patil Andan
- Paunescu Alina
- Pehboeck Daniel
- Pereira Carla
- Pereira Manuela
- Perez Caballero Paula
- Perez Tejero Gisela
- Perez-Cerda Francisco
- Pesenti Antonio
- Petta Rocco
- Philippe Simon
- Pickering David
- Pico Veloso Jandro
- Pina Pedro
- Pinho-Oliveira Vitor
- Pinol Santiago
- Pinto Rita
- Pistidda Laura
- Pitterle Manuela
- Piwowarczyk Pawel
- Plotnikova Olga
- Pohl Holger
- Polakovičová Lucia
- Polderman Jorinde
- Pompei Livia
- Popescu Mihai
- Popovic Radmila
- Pota Vincenzo
- Potocnik Miriam
- Potreć Beata
- Potter Alison
- Pramod Nalwaya
- Prchalova Martina
- Preckel Benedikt
- Pugh Richard
- Pulletz Mark
- Pérez García Aníbal
- Pérez Soto Antonia
- Radoeshki Aleksandar
- Rafi Amir
- Ragazzi Riccardo
- Raineri Santi Maurizio
- Rajamanickam Tamiselvan
- Rajput Zahra
- Ramachandran Rajeskar
- Ramasamy Radhika
- Ramessur Suneil
- Rao Roshan
- Rasmussen Anders
- Rato André
- Razaque Usman
- Real Navacerrada Maria Isabel
- Reavley Caroline
- Reid James
- Reschreiter Henrik
- Rial Erick
- Ribeiro Sandy
- Rich Nathalie
- Richardson Lydia
- Rimaitis Kestutis
- Rimaitis Marius
- Ringvold Else-Marie
- Ripke Fabian
- Ristescu Irina
- Ritchie Keith
- Rodrigues Patrícia
- Rogers Emma
- Rogerson David
- Romagnoli Stefano
- Romero Esther
- Rondovic Goran
- Rose Bernd Oliver
- Roth Winfried
- Rotter Marie-Therese
- Rousseau Guy
- Rudjord Anders
- Rueffert Henrik
- Rundgren Malin
- Rupprecht Korbinian
- Rushton Andrew
- Russotto Vincenzo
- Rypulak Elżbieta
- Ryszka Maciej
- Ródenas Frederic
- Saby Sandrine
- Sagic Jelena
- Saleh Omar
- Sales Gabriele
- Sanchez Sanchez Yvan Enrique
- Sanghera Sumayer
- Santiveri Francisco Xavier
- Santos Sofia
- Sarno Stephen
- Saul Daniel
- Saunders David
- Savić Nenad
- Scalco Loïc
- Scanlon Deborah
- Schax Christoph
- Scheffer Gert Jan
- Schening Anna
- Schiavone Vincenzo
- Schmidt-Ehrenberg Florian
- Schmidt-Mutter Catherine
- Schopflin Christian
- Schreiber Jan-Uwe
- Schultz Marcus
- Schurig Marlen
- Schönberg Christina
- Scott Carmen
- Sebestian Siby
- Sehgal Selena
- Sem Victoria
- Semenas Egidijus
- Serafini Elena
- Serchan Paschalitsa
- Shields Martin
- Shobha Ramakrishnan
- Shosholcheva Mirjana
- Siamansour Tanja Saman
- Siddaiah Narendra
- Siddiqi Khalid
- Sinclair Rhona
- Singh Permendra
- Singh Rajendra
- Sinha Aneeta
- Sinha Ashok
- Skinner Amanda
- Smee Elizabeth
- Smith Neil
- Smith Thomas
- Smitz Carine
- Smole Daniel
- Smékalová Olga
- Sojčić Nataša
- Soler Pedrola Maria
- Somanath Sameer
- Sonksen Julian
- Sorella Maria Cristina
- Soro Marina
- Soto Carmen
- Spada Anna
- Spadaro Savino
- Spaeth Johannes
- Sparr Harald
- Spielmann Annika
- Spindler-Vesel Alenka
- Stamelos Matthaios
- Stancombe Lucia
- Stanculescu Andreea
- Standl Thomas
- Standley Tom
- Stanek Ondrej
- Stanisavljević Snezana
- Starczewska Malgorzata
- Steel Elizabeth
- Steen Julie
- Stefan Oana Mara
- Stera Caterina
- Stevens Markus
- Stoerckel Marlène
- Stošić Biljana
- Stroumpoulis Konstantinos
- Struck Rafael
- Stäuble Christiane
- Suarez de la Rica Alejandro
- Sultanpori Altaf
- Sundara Rajan Rajinikanth
- Suying Ong
- Svensén Christer
- Swan Louise
- Syrogianni Paulina
- Sysiak Justyna
- Szederjesi Janos
- Sá Couto Paula
- Sá Jacinta
- Sõrmus Alar
- Taddei Stefania
- Tan Hao Ern
- Tanou Virginia
- Tarabová Katarína
- Tardaguila Sancho Paula
- Tarroso Maria
- Tartaglione Marco
- Taylor Emma
- Tbaily Lee
- Telford Richard
- Terenzoni Massimo
- Theodoraki Kassiani
- Thornley Helen
- Tiganiuc Liviu
- Toim Hardo
- Tomescu Dana
- Tommasino Concezione
- Toni Jessica
- Toninelli Arturo
- Toretti Ilaria
- Townley Stephen
- Trepenaitis Darius
- Trethowan Brian
- Tsaousi Georgia
- Tsiftsi Aikaterini
- Tudor Andrada
- Turan Guldem
- Turhan Sanem Çakar
- Ulm Kurt
- Ulm Kurt
- Umc Radboud
- Unic-Stojanovic Dragana
- Unterbuchner Christoph
- Unzueta Carmen
- Uranjek Jasna
- Ursic Tomaz
- v Tiesenhausen Anna
- Vaida Simona
- Valldeperas Ferrer Silvia
- Valldeperas Hernandez Maria Inmaculada
- Valsamidis Dimitrios
- Van Beek Rienk
- van Dasselaar Nick
- van der Beek Tim
- Van Duivenvoorde Yoni
- van Klei Wilton A.
- Van Poorten Frans
- Van Zaane Bas
- Van Zundert Tom
- van Zyl Rebekka
- Vargas Munoz Ana Milena
- Varsani Nimu
- Vasconcelos Pedro
- Vassilakis George
- Vecchiatini Tommaso
- Vercauteren Marcel
- Verdouw Bas
- Verheyen Veerle
- Verri Marco
- Večeřa Lubomir
- Vicari Sottosanti Luigi Giancarlo
- Vico Manuel
- Vidal Mitjans Patricia
- Vilardi Anna
- Vissicchio Daniela
- Vitale Giovanni
- Vitković Bibiana
- Vizcaychipi Marcela Paola
- Voicu Alexandra
- Voje Minca
- Volfová Ivana
- Volta Carlo Alberto
- Von Lutterotti Theresia
- Vrecič-Slabe Simona
- Vukcevic Dejan
- Vukovic Rade
- Vullo P. Agostina
- Wade Andrew
- Wallberg Hanna
- Wallden Jakob
- Wallner Johann
- Walther Sturesson Louise
- Watson Davina
- Weber Stefan
- Wegiel Leskiewicz Anna
- Weller Debbie
- Wensing Carin
- Werkmann Markus
- Westberg Henrik
- Wikström Erik
- Willett Emma
- Williams Benedict
- Wilson Robin
- Wirth Steffen
- Wittmann Maria
- Wood Laura
- Wright Stella
- Zachoval Christian
- Zambon Massimo
- Zampieri Silvia
- Zampone Salvatore
- Zangrillo Alberto
- Zani Gianluca
- Zavackiene Asta
- Ziegleder Raphael
- Zonneveldt Harry
- Zsisku Lajos
- Zucker Tom-Philipp
- Zuleika Mehrun
- Zupančič Darja
- Åslin Bjorn
- Şanli Karip Ceren
- Štourač Petr
- Żukowski Maciej
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2019
- Field of study
Background Results from retrospective studies suggest that use of neuromuscular blocking agents during general
anaesthesia might be linked to postoperative pulmonary complications. We therefore aimed to assess whether the use
of neuromuscular blocking agents is associated with postoperative pulmonary complications.
Methods We did a multicentre, prospective observational cohort study. Patients were recruited from 211 hospitals in
28 European countries. We included patients (aged ≥18 years) who received general anaesthesia for any in-hospital
procedure except cardiac surgery. Patient characteristics, surgical and anaesthetic details, and chart review at discharge
were prospectively collected over 2 weeks. Additionally, each patient underwent postoperative physical examination
within 3 days of surgery to check for adverse pulmonary events. The study outcome was the incidence of postoperative
pulmonary complications from the end of surgery up to postoperative day 28. Logistic regression analyses were
adjusted for surgical factors and patients’ preoperative physical status, providing adjusted odds ratios (ORadj) and
adjusted absolute risk reduction (ARRadj). This study is registered with ClinicalTrials.gov, number NCT01865513.
Findings Between June 16, 2014, and April 29, 2015, data from 22803 patients were collected. The use of neuromuscular
blocking agents was associated with an increased incidence of postoperative pulmonary complications in patients who
had undergone general anaesthesia (1658 [7·6%] of 21694); ORadj 1·86, 95% CI 1·53–2·26; ARRadj –4·4%, 95% CI
–5·5 to –3·2). Only 2·3% of high-risk surgical patients and those with adverse respiratory profiles were anaesthetised
without neuromuscular blocking agents. The use of neuromuscular monitoring (ORadj 1·31, 95% CI 1·15–1·49;
ARRadj –2·6%, 95% CI –3·9 to –1·4) and the administration of reversal agents (1·23, 1·07–1·41; –1·9%, –3·2 to –0·7)
were not associated with a decreased risk of postoperative pulmonary complications. Neither the choice of sugammadex
instead of neostigmine for reversal (ORadj 1·03, 95% CI 0·85–1·25; ARRadj –0·3%, 95% CI –2·4 to 1·5) nor extubation at
a train-of-four ratio of 0·9 or more (1·03, 0·82–1·31; –0·4%, –3·5 to 2·2) was associated with better pulmonary outcomes.
Interpretation We showed that the use of neuromuscular blocking drugs in general anaesthesia is associated with an
increased risk of postoperative pulmonary complications. Anaesthetists must balance the potential benefits of
neuromuscular blockade against the increased risk of postoperative pulmonary complications
Post-anaesthesia pulmonary complications after use of muscle relaxants (POPULAR): a multicentre, prospective observational study
- Author
- Abad Gurumeta Alfredo
- Abernethy Caroline
- Abigail Patrick
- Achaibar Kira
- Adam Emily
- Afshari Arash
- Agudelo Montoya María Elizabeth
- Akgün Fatma Nur
- Aletti Gabriele
- Alkış Neslihan
- Allan Ashley
- Allan Katie
- Allaouchiche Bernard
- Allcock Clare
- Almasy Emoke
- Amey Isobel
- Amigoni Maria
- Andersen Elin
- Andersson Peder
- Anipchenko Natalya
- Antunes Pedro
- Armstrong Earlene
- Aslam Tayyba
- Assunção José-Pedro
- Ausserer Julia
- Avvai Mary
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