Measuring the Effectiveness of Photoresponsive Nanocomposite Coatings on Aircraft Windshields to Mitigate Laser Intensity

In 2004, pilots reported 46 laser illumination events to the Federal Aviation Administration (FAA), with the number increasing to approximately 3,600 in 2011. Since that time, the number of reported laser incidents has ranged from 3,500 to 4,000. Previous studies indicate the potential for flight crewmember distraction from bright laser light being introduced to the cockpit. Compositional variations of the photoresponsive nanocomposite coatings were applied to an aircraft windscreen using a modified liquid dispersion/heating curing process. The attenuating effects of the deposited films on laser light intensity were evaluated using an optical power meter and the resultant laser intensity data through treated and untreated windscreens was collected. Data revealed a reduction in laser intensity (36–88%) in the presence of the engineered photoresponsive nanocomposite films. Results lend support of the view that the addition of transparent laser attenuating films applied to aircraft windscreens may improve flight safety, and reduce the risk from distraction or disruption of flight crewmembers’ vision

Activity and Regeneration of Electrodeposited Fe-Ni-Co-Based Electrocatalysts for the Alkaline Oxygen Evolution Reaction

A methodology to recover the oxygen evolution reaction (OER) kinetics of aged, electrodeposited Fe-Ni-Co thin films is presented. The electrodeposits were fabricated galvanostatically onto rotating copper electrodes and contained a small amount of Co. The OER characterized in 1 M KOH was a function of the deposit composition. The Tafel slope and the overpotential at 10 mA/cm2 observed with ohmically corrected linear sweep voltammetry were both a function of the deposit metal ratio, Fe/(Ni + Co), with the lowest values occurring at a ratio of 1.2. An Fe-rich deposit was purposely altered upon aging to degrade the OER kinetics. The Tafel slope and overpotential were largely recovered when the aged electrocatalyst was treated with a cathodic current density of -100 mA/cm2 for 10 min. Soft X-ray absorption spectroscopy provided insight into the changes of the electron density distribution upon aging and regenerating the electrocatalyst. Through X-ray absorption near-edge structure (XANES), the L-edge spectra of Fe, Ni, Co, and K-edge spectra of O, suggested that the recovery is due to the redistribution of the electron density from the oxygen to Fe and Ni

Chromosomal contacts connect loci associated with autism, BMI and head circumference phenotypes

Copy number variants (CNVs) are major contributors to genomic imbalance disorders. Phenotyping of 137 unrelated deletion and reciprocal duplication carriers of the distal 16p11.2 220 kb BP2-BP3 interval showed that these rearrangements are associated with autism spectrum disorders and mirror phenotypes of obesity/underweight and macrocephaly/microcephaly. Such phenotypes were previously associated with rearrangements of the non-overlapping proximal 16p11.2 600 kb BP4-BP5 interval. These two CNV-prone regions at 16p11.2 are reciprocally engaged in complex chromatin looping, as successfully confirmed by 4C-seq, fluorescence in situ hybridization and Hi-C, as well as coordinated expression and regulation of encompassed genes. We observed that genes differentially expressed in 16p11.2 BP4-BP5 CNV carriers are concomitantly modified in their chromatin interactions, suggesting that disruption of chromatin interplays could participate in the observed phenotypes. We also identified cis- and trans-acting chromatin contacts to other genomic regions previously associated with analogous phenotypes. For example, we uncovered that individuals with reciprocal rearrangements of the trans-contacted 2p15 locus similarly display mirror phenotypes on head circumference and weight. Our results indicate that chromosomal contacts’ maps could uncover functionally and clinically related genes