The role of concurrent chemoradiotherapy in the treatment of locoregionally advanced nasopharyngeal carcinoma among endemic population: a meta-analysis of the phase iii randomized trials

<p>Abstract</p> <p>Background</p> <p>The main objective of this meta-analysis was to determine the clinical benefit of concurrent chemoradiotherapy (CCRT) compared with radiation alone (RT) in the treatment of nasopharyngeal carcinoma (NPC) patients in endemic geographic areas.</p> <p>Methods</p> <p>Using a prospective meta-analysis protocol, two independent investigators reviewed the publications and extracted the data. Published randomized controlled trials (RCTs) in which patients with NPC in endemic areas were randomly assigned to receive CCRT or RT alone were included.</p> <p>Results</p> <p>Seven trials (totally 1608 patients) were eligible. Risk ratios (RRs) of 0.63 (95% CI, 0.50 to 0.80), 0.76 (95% CI, 0.61 to 0.93) and 0.74 (95% CI, 0.62 to 0.89) were observed for 2, 3 and 5 years OS respectively in favor of the CCRT group. The RRs were larger than that detected in the previously reported meta-analyses (including both endemic and non-endemic), indicating that the relative benefit of survival was smaller than what considered before.</p> <p>Conclusions</p> <p>This is the first meta-analysis of CCRT vs. RT alone in NPC treatment which included studies only done in endemic area. The results confirmed that CCRT was more beneficial compared with RT alone. However, the relative benefit of CCRT in endemic population might be less than that from previous meta-analyses.</p

Effects of cultivars and nitrogen management on wheat grain yield and protein

Low grain protein in hard red winter (HRW) wheat (Triticum aestivum L.) is a serious challenge for rainfed wheat growers, particularly in years with elevated grain yield. Proper nitrogen (N) management with adequate N rate and application timing is critical for optimizing grain yield and protein content. This 2-yr experiment evaluated the effects of different N rates and application timings (fall, spring, and split) on grain yield and protein of two HRW wheat cultivars. Field studies were conducted at four different sites across Nebraska under rainfed conditions in 2018/2019 (Year 1) and 2019/2020 (Year 2). A split plot randomized complete block design with wheat cultivars as the whole plots and factorial combinations of six N rates and three application timings as the sub-plots was used in four replications. Grain yield was associated positively and grain protein negatively with the water supply to demand ratio (WS:WD) in the season. Freeman cultivar yielded better in a year with higher WS:WD and a newly developed Ruth yielded better in a lower WS:WD year. Nitrogen fertilization significantly increased grain yield in the site-years with moderately higher WS:WD. There was an increase in grain protein with increasing N rates at all site-years. Spring and split applied N resulted in better grain yield than fall application in the site-year when there was a risk of N loss. This experiment suggested that an effective N management strategy for winter wheat should account for and be adaptable to weather variability to optimize grain yield and protein content

Heading percentage estimation in proso millet (Panicum miliaceum L.) using aerial imagery and deep learning

Abstract Proso millet (Panicum miliaceum L.), one of the major cultivated millets, serves as a complement to major cereal crops due to its drought tolerance and low input demands. Timing of heading is one of the key agronomic traits associated with its adaptation to a target environment and a major focus in breeding. Conventionally, heading percentage of a plot (genotype) was rated visually by breeders in field. Despite many successful studies reported in automatic head detections in other small grain species, little progress had been made to estimate heading percentage especially when multiple tillers exist. This study aimed to develop a method for automatic proso millet panicle detection and, more importantly, heading percentage estimation using regular red‐green‐blue images collected by an unmanned aerial vehicle. Aerial images of two dates were collected at heading stage in 2020 in Scottsbluff, NE. Faster regions with convolutional neural network models were trained to detect and count proso millet panicles in each plot. Then, using a sigmoid model, the number of detected panicles was converted to heading percentage without having the information of stand count and the number of tillers. Overall, the system achieved the highest coefficient of determination of 0.728 for proso millet heading percentage estimation, and an accuracy of 92.4% in determining whether a plot reached a certain threshold of heading (50% in this study). The methods developed in this study on heading percentage estimation can directly aid in decision making in proso millet breeding and can be ultimately incorporated into an automated proso millet high‐throughput phenotyping pipeline

Managing Micronutrients for Improving Soil Fertility, Health, and Soybean Yield

Plants need only a small quantity of micronutrients, but they are essential for vital cell functions. Critical micronutrients for plant growth and development include iron (Fe), boron (B), manganese (Mn), zinc (Zn), copper (Cu), molybdenum (Mo), chlorine (Cl), and nickel (Ni). The deficiency of one or more micronutrients can greatly affect plant production and quality. To explore the potential for using micronutrients, we reviewed the literature evaluating the effect of micronutrients on soybean production in the U.S. Midwest and beyond. Soil and foliar applications were the major micronutrient application methods. Overall, studies indicated the positive yield response of soybean to micronutrients. However, soybean yield response to micronutrients was not consistent among studies, mainly because of different environmental conditions such as soil type, soil organic matter (SOM), moisture, and temperature. Despite this inconsistency, there has been increased pressure for growers to apply micronutrients to soybeans due to a fact that deficiencies have increased with the increased use of high-yielding cultivars. Further studies on quantification and variable rate application of micronutrients under different soil and environmental conditions are warranted to acquire more knowledge and improve the micronutrient management strategies in soybean. Since the SOM could meet the micronutrient need of many crops, management strategies that increase SOM should be encouraged to ensure nutrient availability and improve soil fertility and health for sustainable soybean production

The supportive care needs survey short form 34 (SCNS-SF34): translation and cultural adaptation into the Nepali language among patients with cervical cancer in Nepal

Abstract Background A questionnaire developed in one language must be translated and adapted when it will be used with patients speaking a different language and care should be taken to maintain equivalence between the source language (SL) version and its translated version. The objective of this study was to test the linguistic and cultural validity of a Nepali language version of the Supportive Care Need Survey – Short Form 34 (SCNS-SF34) used with the Nepali population. Methods Translation of the SCNS-SF34 was carried out by following Beaton’s guidelines and Consensus-based Standards for the Selection of Health Status Measurement Instruments (COSMIN) by a research team. The translated version was administered to patients with cervical cancer in Nepal. The following steps were performed as part of the study: translation, content validity assessment, reliability assessment and measurement of errors. Results The study reports item content validity (I-CVI) was > 0.78 and scale content validity (S-CVI) was − 0.89, 0.91 and 0.90 respectively in semantic, cultural, and conceptual aspects. The study found a content validity ratio (CVR) of 0.9 to 1, Cronbach’s α of 0.90, correlation significant at the 0.01 level (2-tailed), and clarity of the questionnaire at 91.29%. The standard error of measurement (SEM) and small detectable changes (SDC) for overall care need scores were measured 2.70 and 7.47 respectively. All items were accepted as per the original SCNS-SF34. Following the respondents’ suggestions, simpler Nepali words were chosen in some items to replace the words in the preliminary Nepali version of SCNS-SF34. Conclusion Preliminary findings show that the Nepali translation of SCNS-SF34 is practical and applicable to the Nepali population. Financial supportive care needs, supportive care for caretakers and problems during patient hospital stays are essential to include in the questionnaire to further explore supportive care needs