Functional Performance of Older Adults with Dementia Participating in Adult Day Service Programs

Individuals with dementia are at a high risk of functional decline and falling. The aim of this study was to investigate the possible relationship between cognition and functional performance in older adults with dementia participating in Goodwill Easter Seals adult day service programs. This data may be helpful in understanding how cognition may impact functional performance and fall risk.https://ecommons.udayton.edu/dpt_symposium/1023/thumbnail.jp

Rethinking Representation: Indigenous Peoples and Contexts at the University of Alberta Libraries

Appropriate subject access and descriptive practices within library and information science are social justice issues. Standards that are well established and commonly used in academic libraries in Canada and elsewhere, including Library of Congress Subject Headings (LCSH) and Library of Congress Classification (LCC), continue to perpetuate colonial biases toward Indigenous peoples. In the fall of 2016, the University of Alberta Libraries (UAL) established a Decolonizing Description Working Group (DDWG) to investigate, define, and propose a plan of action for how descriptive metadata practices could more accurately, appropriately, and respectfully represent Indigenous peoples and contexts. The DDWG is currently beginning the implementation of recommendations approved by UAL’s strategic leadership team. In this paper we describe the genesis of the DDWG within the broader context of the libraries’ and the university’s responses to the Truth and Reconciliation Commission of Canada’s Calls to Action; outline the group’s activities and recommendations; and describe initial steps toward the implementation of those recommendations, with a focus on engaging local Indigenous communities. We reflect on the potential impact of revised descriptive practices in removing many of the barriers that Indigenous communities and individuals face in finding and accessing library materials relevant to their cultures and histories

Unsettling our practices: Decolonizing description at the University of Alberta Libraries

See .pdf file

Assessment of the Efficacy of Therapies Following Venetoclax Discontinuation in CLL Reveals BTK inhibition as an Effective Strategy.

PURPOSE: Venetoclax-based therapy is a standard of care option in front-line and relapsed/refractory CLL. Patient management following venetoclax discontinuation remains non-standard and poorly understood. EXPERIMENTAL DESIGN: To address this, we conducted a large international study to identify a cohort of 326 patients who discontinued venetoclax and have been subsequently treated. Co-primary endpoints were overall response rate (ORR) and progression free survival (PFS) for the post-venetoclax treatments stratified by treatment type (BTKi, PI3Ki, and cellular therapies). RESULTS: We identified CLL patients who discontinued venetoclax in the front-line (4%) and relapsed/refractory settings (96%). Patients received a median of three therapies prior to venetoclax; 40% were BTKi naïve (n=130), and 81% were idelalisib naïve (n=263). ORR to BTKi was 84% (n=44) in BTKi-naïve patients vs. 54% (n=30) in BTKi-exposed patients. We demonstrate therapy selection following venetoclax requires prior novel agent exposure consideration and discontinuation reasons. CONCLUSIONS: For BTKi naïve patients, selection of covalently binding BTKis results in high ORR and durable remissions. For BTKi exposed patients, covalent BTK inhibition is not effective in the setting of BTKi resistance. PI3Kis following venetoclax do not appear to result in durable remissions. We conclude that BTKi in naïve or previously responsive patients and cellular therapies following venetoclax may be the most effective strategies