124 research outputs found
Synthesis, Characterization and Antitumour Activity of Di-n-Butyltin Salicyloxamate
Journal Articleinfo:eu-repo/semantics/publishe
Synthesis, Characterization and In Vitro Antitumour Activity of Di-n-Butyl, Tri-n-Butyl and Triphenyltin 3,6-Dioxaheptanoates and 3,6,9-Trioxadecanoates
A series of di- and triorganotin 3,6-dioxaheptanoates and 3,6,9-trioxadecanoates were synthesized and
characterized by 1H, 13 and 117Sn NMR, electrospray mass and 119mSn Mössbauer spectroscopy, as well as
elemental analysis. Their in vitro antitumour activity against seven tumoural cell lines of human origin, two
breast cancers (MCF-7, EVSA-T), a colon carcinoma (WiDr), an ovarian cancer (IGROV), a melanoma (M 19
MEL), a renal cancer (A 498) and a non small cell lung cancer (H 226), is reported. They are characterized by
similar inhibition doses ID50 as the analogous di- and triorganotin derivatives of 4-carboxybenzo-15-crown-5
and -18-crown-6 and in some cases by much lower ID50 values than clinically used reference compounds such
as doxorubicine and methotrexate
Di-n-Butyl-, Tri-n-Butyl- and Triphenyltin dl-Terebates: Synthesis, Characterization and In Vitro Antitumour Activity
Di-n-butyltin, tri-n-butyltin and triphenyltin terebates were screened against several human tumour cell lines and found comparably or more active than carboplatin, cis-platin, 5-fluorouracil, methotrexate and doxorubicin, some reference compounds used clinically
Synthesis, Characterization and Antitumour Activities of Di-n-Butyl- and Dimethyltin D-(+)-Camphorates
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Synthesis, Characterization and High In Vitro Antitumour Activity of Novel Triphenyltin Carboxylates
The synthesis and spectral characterization of six novel triphenyltin compounds are described. The
in vitro antitumour activity of three of these compounds against two human tumour cell lines, MCF-7,
a mammary tumour, and WiDr, a colon carcinoma, was determined. All three compounds are more
active than cis-platin, etoposide and doxorubicin against both tumour cell lines. They are as active
as mitomycin C against WiDr, but less active against MCF-7
Synthesis, IR, Mössbauer and solid-state NMR studies of 1,1-dimethylguanidinium triphenyltin sulphate
Synthesis, Characterization and In vitro Antitumour Activity of Novel Organotin Derivatives of 1,2- and 1,7-Dicarba-Closo-dodecaboranes
Several organotin derivatives of 1,2- and 1,7-dicarba-closo-dodecaboranes were
synthesized and characterized by 119Sn Mössbauer, 1H, 13C and 119Sn NMR spectroscopy.
Their antitumour activities in vitro against cancerous cell lines of human origin are reported
Mathematical modelling for the generation of L-[3-2H,3-13C]lactic acid isotopomers by erythrocytes exposed to either D-[1-13C]glucose or D-[6- 13C]glucose in the presence of 2H2O
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Delayed interconversion of D-glucose anomers in D2O.
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Two-dimensional 1H-119Sn proton detected correlation spectroscopy in coordination chemistry of hypervalent organotin compounds
info:eu-repo/semantics/publishe
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