Correlation of Aqueous Solubility and Anti-Cancer Activity of Novel Triazolium and Imidazolium Salts

Novel triazolium, imidazolium, and benzimidazolium salts are known to possess anti-cancer properties and have potential as cancer therapeutics. This thesis describes the aqueous solubility and the differential activity of N,AT-bis-substituted-l,2,4-triazolium bromide salts and N/N\u27-bis(naphthylmethyl)imidazolium bromide salts against MDA-MB-468 breast cancer cells and PC-3 prostate carcinomas. Using a microscale technique, the partition coefficient (log P) of each salt was determined. The log P value was explored to determine the bioavailability of each derivative

Phonon Dispersion Effects and the Thermal Conductivity Reduction in GaAs/AlAs Superlattices

The experimentally observed order-of-magnitude reduction in the thermal conductivity along the growth axis of (GaAs)_n/(AlAs)_n (or n x n) superlattices is investigated theoretically for (2x2), (3x3) and (6x6) structures using an accurate model of the lattice dynamics. The modification of the phonon dispersion relation due to the superlattice geometry leads to flattening of the phonon branches and hence to lower phonon velocities. This effect is shown to account for a factor-of-three reduction in the thermal conductivity with respect to bulk GaAs along the growth direction; the remainder is attributable to a reduction in the phonon lifetime. The dispersion-related reduction is relatively insensitive to temperature (100 < T < 300K) and n. The phonon lifetime reduction is largest for the (2x2) structures and consistent with greater interface scattering. The thermal conductivity reduction is shown to be appreciably more sensitive to GaAs/AlAs force constant differences than to those associated with molecular masses.Comment: 5 figure

Statistical Properties of Many Particle Eigenfunctions

Wavefunction correlations and density matrices for few or many particles are derived from the properties of semiclassical energy Green functions. Universal features of fixed energy (microcanonical) random wavefunction correlation functions appear which reflect the emergence of the canonical ensemble as the number of particles approaches infinity. This arises through a little known asymptotic limit of Bessel functions. Constraints due to symmetries, boundaries, and collisions between particles can be included.Comment: 13 pages, 4 figure

Eigenstate Structure in Graphs and Disordered Lattices

We study wave function structure for quantum graphs in the chaotic and disordered regime, using measures such as the wave function intensity distribution and the inverse participation ratio. The result is much less ergodicity than expected from random matrix theory, even though the spectral statistics are in agreement with random matrix predictions. Instead, analytical calculations based on short-time semiclassical behavior correctly describe the eigenstate structure.Comment: 4 pages, including 2 figure

Recent Decisions

Comments on recent decisions by Edward M. O\u27Toole, John J. Coffey, Richard M. Bies, Thomas Kavadas, Jr., J. Michael Guenther, John R. Martzell, William J. Luff, William R. Kennedy, Thomas L. Shaffer, and Paul J. Schierl

Recent Decisions

Comments on recent decisions by Edward M. O\u27Toole, John J. Coffey, Richard M. Bies, Thomas Kavadas, Jr., J. Michael Guenther, John R. Martzell, William J. Luff, William R. Kennedy, Thomas L. Shaffer, and Paul J. Schierl