2 research outputs found
results of a randomized controlled trial
Bile acids (BAs) are increasingly recognised as metabolic regulators,
potentially improving insulin sensitivity following bariatric surgery.
However, physiological relevance of such observations remains unknown. Hence,
we analysed serum BA composition and associated gut-derived hormone levels
following lifestyle-induced weight loss in individuals with metabolic syndrome
(MetS). 74 non-smoking men (45–55 yr) with MetS were randomised to a
lifestyle-induced weight loss program (supervision via telemonitoring) or to a
control arm. Before and after a 6 months intervention period clinical and
laboratory parameters, body composition, serum BA profile, FGF-19, and GLP-1
concentrations were determined in fasting blood samples. 30 participants in
the control and 33 participants in the treatment arm completed the study and
were included in the data analysis. In participants of the treatment arm
lifestyle-induced weight loss resulted in markedly improved insulin
sensitivity. Serum levels of BA species and total GLP-1 decreased, while
FGF-19 remained stable. Serum BA composition changed towards an increased 12α-
hydroxylated/non-12α-hydroxylated ratio. None of these parameters changed in
participants of the control arm. Our results demonstrate that improved
metabolic control by lifestyle modifications lowers serum levels of BAs and
GLP-1 and changes serum BA composition towards an increased 12α/non-12α ratio
(ICTRP Trial Number: U1111-1158-3672)