(18-Crown-6-κ6 O)(pyrazolato-κ2 N,N′)-potassium(I)

The asymmetric unit of the title compound, [K(C3H3N2)(C12H24O6)], is composed of a potassium cation bonded to the six O atoms of a crown ether mol­ecule and the two N atoms of a pyrazolate anion. The K⋯O distances range from 2.8416 (8) to 3.0025 (8) Å, and the two K⋯N distances are 2.7441 (11) and 2.7654 (11) Å. The K cation is displaced by 0.8437 (4) Å from the best plane through the six O atoms. The latter plane is almost perpendicular to the plane of the pyrazolate ring [dihedral angle 83.93 (3)°]

Poly[diaqua­[3,5-bis­(trifluoro­meth­yl)pyrazolido]potassium]

The asymmetric unit of the title compound, [K(C5HF6N2)(H2O)2]n, is composed of two 3,5-bis­(trifluoro­meth­yl)pyrazol­ide anions, two potassium cations and four water mol­ecules. The water mol­ecules and 3,5-bis­(trifluoro­meth­yl)pyrazolide anions act as bridges between the potassium cations. Each potassium cation is surrounded by four O atoms [K—O = 2.705 (3)–2.767 (3) Å] and four F atoms [K—F = 2.870 (7)–3.215 (13) Å]. The water mol­ecules and the 3,5-bis­(trifluoro­meth­yl)pyrazolide anions are connected by O—H⋯N hydrogen bonds, forming layers in the ab plane. All –CF3 groups show rotational disorder between two orientations each

FoxQ1 Overexpression Influences Poor Prognosis in Non-Small Cell Lung Cancer, Associates with the Phenomenon of EMT

BACKGROUND: We determined the expression of forkhead box Q1 (FoxQ1), E-cadherin (E-cad), Mucin 1 (MUC1), vimentin (VIM) and S100 calcium binding protein A4 (S100A4), all epithelial-mesenchymal transition (EMT) indicator proteins in non-small cell lung cancer (NSCLC) tissue samples. We also investigated the relationship between these five proteins expression and other clinicopathologic factors in NSCLC. Finally, we assessed the potential value of these markers as prognostic indicators of survival in NSCLC's patients. METHODS: Quantitative real-time PCR and immunohistochemistry were used to characterize the expression of the FoxQ1 mRNA and protein in NSCLC. Expression of transcripts and translated products for the other four EMT indicator proteins was assessed by immunohistochemistry in the same clinical NSCLC samples. RESULTS: FoxQ1 mRNA and protein were up-regulated in NSCLC compared with normal tissues (P = 0.015 and P<0.001, respectively). Expression of FoxQ1 in adenocarcinoma was higher than in squamous cell carcinoma (P = 0.005), and high expression of FoxQ1 correlated with loss of E-cad expression (P = 0.012), and anomalous positivity of VIM (P = 0.024) and S100A4 (P = 0.004). Additional survival analysis showed that high expression of FoxQ1 (P = 0.047) and E-cad (P = 0.021) were independent prognostic factors. CONCLUSION: FoxQ1 maybe plays a specific role in the EMT of NSCLC, and could be used as a prognostic factor for NSCLC

Dichtequellen und Dichtesenken als dissipative Strukturen in Diffusionsflammen organischer Fluessigkeiten

SIGLETIB Hannover: DR 5019 / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekDEGerman

Stepwise Transfer from High to Low Lithium Concentrations Increases the Head-Forming Potential inHydra vulgarisand Possibly Activates the PI Cycle

AbstractLithium ions affect pattern formation in the freshwater polypHydra vulgarisin a complex manner. Although a long-term treatment with 1 mMLiCl completely suppresses both head formation and budding, a reduction of the lithium concentration during a long-term treatment from 4 to 1 mMLiCl strongly promotes the differentiation of ectopic head structures. Meanwhile, budding, often interpreted as a special case of head formation, remains suppressed. The appearance of ectopic tentacles under these conditions is surprising as they develop while the animals remain in the presence of 1 mMLiCl, a concentration which would normally suppress the formation of tentacles. On a molecular level, the induction of ectopic head structures by the shift in the LiCl concentration is preceded by an increase in the level of inositol phosphates, indicating an activation of the phosphatidylinositol (PI) cycle. Increased inositol phosphate levels persist for at least 24 hr. Our results provide evidence that (i) tentacle- and bud-forming systems need different and possibly mutually exclusive physiological preconditions and (ii) prolonged inhibition of the PI cycle after initial activation might be necessary to obtain ectopic tentacles

Turkey breeder management

"The goal of every flockowner should be to produce eggs from which quality poults can be hatched. The practices outlined in this guide are based upon the best information available to help you attain this goal."--First page.Harold Biellier and Walter Russell (Department of Poultry Husbandry, College of Agriculture)New 6/79/8