Changes in self-schema structure in cognitive therapy for major depressive disorder: a randomized clinical trial.

Negative cognitive structure (particularly for interpersonal content) has been shown in some research to persist past a current episode of depression and potentially to be a stable marker of vulnerability for depression (D. J. A. Dozois, 2007; D. J. A. Dozois & K. S. Dobson, 2001a). Given that cognitive therapy (CT) is highly effective for treating the acute phase of a depressive episode and that this treatment also reduces the risk of relapse and recurrence, it is possible that CT may alter these stable cognitive structures. In the current study, patients were randomly assigned to CT+ pharmacotherapy (n = 21) or to pharmacotherapy alone (n = 21). Both groups evidenced significant and similar reductions in level of depression (as measured with the Beck Depression Inventory-II and the Hamilton Rating Scale for Depression), as well as automatic thoughts and dysfunctional attitudes. However, group differences were found on cognitive organization in favor of individuals who received the combination of CT+ pharmacotherapy. The implications of these results for understanding mechanisms of change in therapy and the prophylactic nature of CT are discussed

Changes in Core Beliefs (Early Maladaptive Schemas) and Self-Representation in Cognitive Therapy and Pharmacotherapy for Depression

Randomized clinical trials suggest that cognitive therapy (CT) is comparable to antidepressant medication for the acute treatment of depression. Compelling data also indicate that CT has an added prophylactic benefit relative to pharmacotherapy (PT). The purpose of this study was to examine cognitive change in CT for depression. Participants (N = 42) met diagnostic criteria for a current major depressive episode and were randomly assigned to CT + PT or PT. Participants completed indices of depressive symptomatology, core beliefs (i.e., early maladaptive schemas), and self-attribute redundancy before and after therapy. Self-attribute redundancy was conceptualized as a form of schema organization and operationalized as the number of similar traits that permeate different aspects of self (e.g., as a partner, friend, employee). Treatment change was evident in both groups on self-reported core belief domains, with few between-group differences. Although no group differences were found on attribute redundancy at pre-treatment, there was a significant increase in positive redundancy at post-treatment favoring CT + PT. No group differences were found for negative content. These findings suggest that something about CT may uniquely impact self-representation and that CT may operate by bolstering compensatory schemas

Modeling the mental health service utilization decisions of university undergraduates: A discrete choice conjoint experiment

Objective: We modeled design factors influencing the intent to use a university mental health service. Participants: Between November 2012 and October 2014, 909 undergraduates participated. Method: Using a discrete choice experiment, participants chose between hypothetical campus mental health services. Results: Latent class analysis identified three segments. A Psychological/Psychiatric Service segment (45.5%) was most likely to contact campus health services delivered by psychologists or psychiatrists. An Alternative Service segment (39.3%) preferred to talk to peer-counselors who had experienced mental health problems. A Hesitant segment (15.2%) reported greater distress but seemed less intent on seeking help. They preferred services delivered by psychologists or psychiatrists. Simulations predicted that, rather than waiting for standard counseling, the Alternative Service segment would prefer immediate access to E-Mental health. The Usual Care and Hesitant segments would wait 6 months for standard counseling. Conclusions: E-Mental Health options could engage students who may not wait for standard services.This project was supported by the Jack Laidlaw Chair in Patient-Centered Health Care and a grant from the Canadian Health Services Research Foundation

Sociotropy and autonomy and the interpersonal model of depression: an integration

Researchers and theorists have suggested that two personality styles may serve as pathways for the development of depression. One personality style, sociotropy, involves intense needs for positive interchange with others, whereas the other style, autonomy, involves an excessive need for self-control and independence. These personality styles were investigated in the context of Coyne's (1976) interpersonal model of depression, which suggests that depressed persons are rejected by others. Research on this model has been equivocal, and it is possible that these two personality dimensions result in meaningful interpersonal differences within depressed persons. Depressed outpatients, (N=41) and non-depressed controls (N=41) were assessed on sociotropy and autonomy and then participated in a brief task in which a research assistant helped them plan adaptive life changes. These interactions were rated subjectively and utilizing behavioural coding. Results indicated that a combination of depression and autonomy were particularly likely to lead to rejection and less positive interpersonal behaviours. Sociotropy was related to perceptions of interpersonal deference, whereas depression was associated with self-orientation in the task. These results suggest that both depression and personality impact rejection and interpersonal behaviours in social interactions. Overall, this study represents a significant step toward greater specificity in the interpersonal model of depression, and clinical implications of these findings are described.Arts, Faculty ofPsychology, Department ofGraduat

Interpersonal differences in sociotropic and autonomous dysthymic subtypes

The current study reviews theoretical and research evidence which links the concepts of sociotropy and autonomy to depression. The concepts of sociotropy and autonomy have been implicated as relevant factors in pre-disposing individuals to depression and as influencing the experience of depression; however, important postulated interpersonal differences have not been examined empirically. The current study explores theoretical interpersonal differences in sociotropic or autonomous dysthymic women. The motivational goals, interpersonal concerns, and other perceptions of sociotropic and autonomous individuals were assessed after an interpersonal interaction. Subjects who were found to be dysthymic and displayed excessive sociotropy or autonomy were asked to participate in a laboratory task with a confederate who acted either in a controlling or passive manner. Sociotropic subjects were more motivated by interpersonal goals in the interaction than autonomous subjects. Sociotropes were more dependent on their partners and felt that they had to rely on them to a greater extent for support, help, and advice; they also attempted to please their partner and were concerned about their partner's evaluation of them. These individuals felt their partner had evaluated them positively, was dependable, and was pleased with them. On the other hand, autonomous individuals felt that they were being intruded upon by their partner during the interaction, that their partner had acted in a controlling manner, and that their partner had perfectionistic standards. Perceptions of others was independent of actual behaviour of interaction partners. Moreover, sociotropic subjects were better liked by confederates than were autonomous subjects and confederates rated sociotropics as more likeable. These results indicate that sociotropic individuals are more interpersonally oriented than autonomous individuals and that these individuals not only perceive others differently, but are perceived differently by others. Implications for interpersonal models of depression are discussed and the possible impact of these differences on the experience of depression are examined.Arts, Faculty ofPsychology, Department ofGraduat

Micropattern-guided assembly of overlapping pairs of dynamic microtubules.

Interactions between antiparallel microtubules are essential for the organization of spindles in dividing cells. The ability to form immobilized antiparallel microtubule pairs in vitro, combined with the ability to image them via TIRF microscopy, permits detailed biochemical characterization of microtubule cross-linking proteins and their effects on microtubule dynamics. Here, we describe methods for chemical micropatterning of microtubule seeds on glass surfaces in configurations that specifically promote the formation of antiparallel microtubule overlaps in vitro. We demonstrate that this assay is especially well suited for reconstitution of minimal midzone overlaps stabilized by the antiparallel microtubule cross-linking protein PRC1 and its binding partners. The micropatterning method is suitable for use with a broad range of proteins, and the assay is generally applicable to any microtubule cross-linking protein