Baseline characteristics.

<p>Baseline characteristics.</p

Sub-networks showing the ten parameters most related to plasma level of EPO during malaria.

<p>Sub-networks obtained for (A) the NCM group and the (B) CM group. Nodes with the highest number of connections with other parameters are represented by hexagons. For each parameter, the size of the node is associated with its level of correlation with EPO levels. Interactions between parameters are represented by edges (lines), thicker lines representing a higher confidence level for a given interaction.</p

Erythropoietin levels increase during cerebral malaria and with severity of the infection.

<p>(A) Erythropoietin (EPO) levels were measured in the plasma of endemic controls (EC), mild malaria (MM) and severe malaria (SM) patients, and (B) in the SM sub-groups of non-cerebral malaria (NCM) and cerebral malaria (CM). (C) EPO levels were compared between CM patients who survived and those who did not. Significant differences with the EC group or between selected groups are indicated as the following: *<i>p</i> ≤ 0.05; **<i>p</i> ≤ 0.01; ***<i>p</i> ≤ 0.001.</p

Multiple correlation analyses of [EPO + hemopexin + total heme] with [TNF-α + IL-10 + IP-10 + MCP-1] for all <i>P</i>. <i>falciparum</i>-infected patients.

<p>Multiple correlation analyses of [EPO + hemopexin + total heme] with [TNF-α + IL-10 + IP-10 + MCP-1] for all <i>P</i>. <i>falciparum</i>-infected patients.</p

Correlation of EPO plasma levels, with cytokines.

<p>Correlation of EPO plasma levels, with cytokines.</p

Correlation of erythropoietin plasma levels, with biological parameters.

<p>Correlation of erythropoietin plasma levels, with biological parameters.</p

Multiple correlation analyses of [EPO + hemopexin + total heme] with [TNF-α + IL-10 + IP-10 + MCP-1] during NCM.

<p>Multiple correlation analyses of [EPO + hemopexin + total heme] with [TNF-α + IL-10 + IP-10 + MCP-1] during NCM.</p

Multiple correlation analyses of [EPO + hemopexin + total heme] with [TNF-α + IL-10 + IP-10 + MCP-1] during MM.

<p>Multiple correlation analyses of [EPO + hemopexin + total heme] with [TNF-α + IL-10 + IP-10 + MCP-1] during MM.</p

Multiple correlation analyses of [EPO + hemopexin + total heme] with [TNF-α + IL-10 + IP-10 + MCP-1] during CM.

<p>Multiple correlation analyses of [EPO + hemopexin + total heme] with [TNF-α + IL-10 + IP-10 + MCP-1] during CM.</p