Estudio comparativo con microscopio láser confocal de la superficie del esmalte luego de la aplicación de diferentes técnicas de remoción del material de adhesión de brackets

El propósito de ésta investigación, fue observar y cuantificar la rugosidad del esmalte dental después de eliminar el adhesivo residual al retirar los brackets. Sobre 30 premolares humanos se realizó la adhesión de brackets en el centro de la cara vestibular, los cuales a las 24 horas fueron descementados y pulido el adhesivo residual con tres métodos distintos, fresa de múltiples filos (12 filos) tronco cónica con instrumental rotatorio a alta velocidad irrigada con agua; fresa redonda con instrumental rotatorio a baja velocidad (contra ángulo) sin irrigación y fresa de vidrio (Fiber Glass) con instrumental rotatorio a baja velocidad (contra ángulo) sin irrigación. Antes de adherir los brackets y después de su retiro y eliminación del adhesivo residual con los diferentes métodos, los elementos dentarios fueron observados con microscopio láser Confocal y la rugosidad fue medida utilizando el software digital OLYMPUS OLS-4100, donde se realiza una reconstrucción tridimensional. Los resultados indicaron que la fresa de múltiples filos a alta velocidad y con irrigación con agua es la que deja la superficie con parámetros de rugosidad más bajos. Por lo tanto, la fresa de múltiples filos sería el método más indicado para eliminar la resina residual posterior al retiro de los brackets al final de un tratamiento de ortodoncia.Fil: Bianchini, Elisa. Universidad Nacional de Córdoba. Facultad de Odontología; Argentina

RSOS Quantum Chains Associated with Off-Critical Minimal Models and Zn\mathbb{Z}_n Parafermions

We consider the $\varphi_{1,3}$ off-critical perturbation ${\cal M}(m,m';t)$ of the general non-unitary minimal models where $2\le m\le m'$ and $m, m'$ are coprime and $t$ measures the departure from criticality corresponding to the $\varphi_{1,3}$ integrable perturbation. We view these models as the continuum scaling limit in the ferromagnetic Regime III of the Forrester-Baxter Restricted Solid-On-Solid (RSOS) models on the square lattice. We also consider the RSOS models in the antiferromagnetic Regime II related in the continuum scaling limit to $\mathbb{Z}_n$ parfermions with $n=m'-2$. Using an elliptic Yang-Baxter algebra of planar tiles encoding the allowed face configurations, we obtain the Hamiltonians of the associated quantum chains defined as the logarithmic derivative of the transfer matrices with periodic boundary conditions. The transfer matrices and Hamiltonians act on a vector space of paths on the $A_{m'-1}$ Dynkin diagram whose dimension is counted by generalized Fibonacci numbers.Comment: 18 page

Differential Analysis of Gly211Val and Gly286Val Mutations Affecting Sarco(endo)plasmic Reticulum Ca2+-ATPase (SERCA1) in Congenital Pseudomyotonia Romagnola Cattle.

Congenital pseudomyotonia in cattle (PMT) is a rare skeletal muscle disorder, clinically characterized by stiffness and by delayed muscle relaxation after exercise. Muscle relaxation impairment is due to defective content of the Sarco(endo)plasmic Reticulum Ca2+ ATPase isoform 1 (SERCA1) protein, caused by missense mutations in the ATP2A1 gene. PMT represents the only mammalian model of human Brody myopathy. In the Romagnola breed, two missense variants occurring in the same allele were described, leading to Gly211Val and Gly286Val (G211V/G286V) substitutions. In this study, we analyzed the consequences of G211V and G286V mutations. Results support that the reduced amount of SERCA1 is a consequence of the G211V mutation, the G286V mutation almost being benign and the ubiquitin-proteasome system (UPS) being involved. After blocking the proteasome using a proteasome inhibitor, we found that the G211V mutant accumulates in cells at levels comparable to those of WT SERCA1. Our conclusion is that G211/286V mutations presumably originate in a folding-defective SERCA1 protein, recognized and diverted to degradation by UPS, although still catalytically functional, and that the main role is played by G211V mutation. Rescue of mutated SERCA1 to the sarcoplasmic reticulum membrane can re-establish resting cytosolic Ca2+ concentration and prevent the appearance of pathological signs, paving the way for a possible therapeutic approach against Brody disease

Chemotherapy patient perception regarding communication with the healthcare staff

Purpose: To qualitatively explore the communication between healthcare professionals and oncology patients based on the perception of patients undergoing chemotherapy.Method: Qualitative and exploratory design. Participants were 14 adult patients undergoing chemotherapy at different stages of the disease. A socio-demographic and clinical data form was utilized along with semi-structured interviews. The interviews were audio-recorded, transcribed and content analysis was performed. Two independent judges evaluated the interview content in regards to emerging categories and obtained a Kappa index of 0.834.Results: Three categories emerged from the data: 1) Technical communication without emotional support, in which the information provided is composed of strictly technical information regarding the diagnosis, treatment and/or prognosis; 2) Technical communication, in which the information provided is oriented towards the technical aspects of the patient’s physical condition, while also providing psychological support for the patients’ subjective needs; and 3) Insufficient technical communication, win which there are gaps in the information provided causing confusion and suffering to the patient.Conclusions: Communication with emotional support contributes to greater satisfaction of chemotherapy patients. Practical implications: the results provide elements for the training of healthcare professionals regarding the importance of the emotional support that can be offered to cancer patients during their treatment.</p