Training to estimate blood glucose and to form associations with initial hunger

BACKGROUND: The will to eat is a decision associated with conditioned responses and with unconditioned body sensations that reflect changes in metabolic biomarkers. Here, we investigate whether this decision can be delayed until blood glucose is allowed to fall to low levels, when presumably feeding behavior is mostly unconditioned. Following such an eating pattern might avoid some of the metabolic risk factors that are associated with high glycemia. RESULTS: In this 7-week study, patients were trained to estimate their blood glucose at meal times by associating feelings of hunger with glycemic levels determined by standard blood glucose monitors and to eat only when glycemia was < 85 mg/dL. At the end of the 7-week training period, estimated and measured glycemic values were found to be linearly correlated in the trained group (r = 0.82; p = 0.0001) but not in the control (untrained) group (r = 0.10; p = 0.40). Fewer subjects in the trained group were hungry than those in the control group (p = 0.001). The 18 hungry subjects of the trained group had significantly lower glucose levels (80.1 ± 6.3 mg/dL) than the 42 hungry control subjects (89.2 ± 10.2 mg/dL; p = 0.01). Moreover, the trained hungry subjects estimated their glycemia (78.1 ± 6.7 mg/dL; estimation error: 3.2 ± 2.4% of the measured glycemia) more accurately than the control hungry subjects (75.9 ± 9.8 mg/dL; estimation error: 16.7 ± 11.0%; p = 0.0001). Also the estimation error of the entire trained group (4.7 ± 3.6%) was significantly lower than that of the control group (17.1 ± 11.5%; p = 0.0001). A value of glycemia at initial feelings of hunger was provisionally identified as 87 mg/dL. Below this level, estimation showed lower error in both trained (p = 0.04) and control subjects (p = 0.001). CONCLUSION: Subjects could be trained to accurately estimate their blood glucose and to recognize their sensations of initial hunger at low glucose concentrations. These results suggest that it is possible to make a behavioral distinction between unconditioned and conditioned hunger, and to achieve a cognitive will to eat by training

Vehicle-to-Grid and ancillary services:a profitability analysis under uncertainty

The rapid and massive diffusion of electric vehicles poses new challenges to the electric system, which must be able to supply these new loads, but at the same time opens up new opportunities thanks to the possible provision of ancillary services. Indeed, in the so-called Vehicle-to-Grid (V2G) set-up, the charging power can be modulated throughout the day so that a fleet of vehicles can absorb an excess of power from the grid or provide extra power during a shortage.To this end, many works in the literature focus on the optimization of each vehicle daily charging profiles to offer the requested ancillary services while guaranteeing a charged battery for each vehicle at the end of the day. However, the size of the economic benefits related to the provision of ancillary services varies significantly with the modeling approaches, different assumptions, and considered scenarios. In this paper we propose a profitability analysis with reference to a recently proposed framework for V2G optimal operation in presence of uncertainty. We provide necessary and sufficient conditions for profitability in a simplified case and we show via simulation that they also hold for the general case.Comment: Accepted by IFAC for publication under a Creative Commons Licence CC-BY-NC-N

The NuSTAR view of the Seyfert Galaxy HE 0436-4717

We present the multi epoch spectral analysis of HE 0436-4717, a bright Seyfert 1 galaxy serendipitously observed by the high energy satellite NuSTAR four times between December 2014 and December 2015. The source flux shows modest variability within each pointing and among the four observations. Spectra are well modelled in terms of a weakly variable primary power law with constant photon index ($\Gamma$=2.01$\pm$0.08). A constant narrow \ion{Fe} K$\alpha$ emission line suggests that this feature has an origin far from the central black hole, while a broad relativistic component is not required by the data. The Compton reflection component is also constant in flux with a corresponding reflection fraction R=0.7$^{+0.2}_{-0.3}$. The iron abundance is compatible with being Solar (A$_{Fe}$=1.2$^{+1.4}_{-0.4}$), and a lower limit for the high energy cut-off E$_c$>280 keV is obtained. Adopting a self-consistent model accounting for a primary Comptonized continuum, we obtain a lower limit for the hot corona electron temperature kT$_e$>65 keV and a corresponding upper limit for the coronal optical depth of $\tau_e$<1.3. The results of the present analysis are consistent with the locus of local Seyfert galaxies in the kT$_e$-$\tau_e$ and temperature-compactness diagrams.Comment: accepted for publication in A&

ATLASrift - a Virtual Reality application

We present ATLASrift - a Virtual Reality application that provides an interactive, immersive visit to ATLAS experiment. We envision it being used in two different ways: first as an educational and outreach tool - for schools, universities, museums and interested individuals, and secondly as an event viewer for ATLAS physicists - for them it will provide a much better spatial awareness of an event, track and jet directions, occupancies and interactions with detector structures. Using it, one can learn about the experiment as a whole, visit individual sub-detectors, view real interactions, or take a scripted walkthrough explaining questions physicists are trying to answer. We briefly describe our platform of choice - OculusRift VR system, the development environment - UnrealEngine, and, in detail, the numerous technically demanding requirements that had to be fulfilled in order to provide a comfortable user experience. Plans for future versions include making the experience social by adding multi-user/virtual presence options, event animation, interactive virtual demonstrations of key high energy physics concepts, or detector operating principles.Comment: Presentation at the DPF 2015 Meeting of the American Physical Society Division of Particles and Fields, Ann Arbor, Michigan, August 4-8, 201

Persistent Specialization and Growth:The Italian Land Reform

Land distribution has ambiguous effects on structural transformation: large landowners can slow industrialization by limiting the provision of education, but larger scale andlocal market power might accelerate the mechanization of production. We examine theeffects of redistribution following the Italian 1950 land reform and find that redistribution led to less industrialization. We explain this finding with a reduction in the scale ofoperations and a more intensive use of family labor. Agricultural specialization persistedfor at least 50 years, consistent with models of occupational inheritance. Finally, we showthat expropriated areas had lower growth during 1970-2000

Direct Arylation Strategies in the Synthesis of π-Extended Monomers for Organic Polymeric Solar Cells

π-conjugated macromolecules for organic polymeric solar cells can be rationally engineered at the molecular level in order to tune the optical, electrochemical and solid-state morphology characteristics, and thus to address requirements for the efficient solid state device implementation. The synthetic accessibility of monomers and polymers required for the device is getting increasing attention. Direct arylation reactions for the production of the π-extended scaffolds are gaining importance, bearing clear advantages over traditional carbon-carbon forming methodologies. Although their use in the final polymerization step is already established, there is a need for improving synthetic accessibility to implement them also in the monomer synthesis. In this review, we discuss recent examples highlighting this useful strategy

Frequency of sexually transmitted diseases and main methodological implications

Background. High risk Human Papillomavirus (HR-HPV) persistence is the most important cervical cancer risk factor, while Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG), Mycoplasma hominis (MH), Mycoplasma genitalium(MG), Ureaplasma urealyticum (UU) and parvum (UP) are sexually transmitted diseases (STDs) causing infertility, pregnancy complication, lung problems in newborns. Methods. 135 urine, 135 urethral swabs, 553 cervical swabs, 110 seminal fluids and 1440 Thin Prep, were tested with culture methods, Real-Time PCR (RT-PCR) and multiplex SYBR Green PCR-endpoint to detect STDs. PCR- endpoint was performed to detect HPV. Results. Culture methods showed the lowest sensitivity: for MH it was only 24% (compared to RT-PCR). UP/UU were the most frequent pathogens (13% with culture, 29% with PCR-endpoint, 41,67% with RT-PCR). Turn Around Time was respectively: 48h, 6h and 2h. RT-PCR cervical frequencies for CT, MH, MG, UU, UP were: 5.42%, 11.03%, 1.81%, 11.21% and 35.08%. HPV positivity in primary and secondary screening was 17.33% and 51.14%. Highes t positivity age group was: 23-32 years for CT (17%), and 18-27 years for HPV (33%). Conclusions. RT-PCR is more sensitive, faster, less expensive than other molecular tests like PCR-endpoint and microarrays. It allows more efficient laboratory organization: pre-analytical phase is more automated and enable the implementation of further diagnostic tests for pathologies that need rapid identification, such as meningitidis and sepsis, with reduced human and instrumental resource. Regarding STDs screening, it should be performed in women: for CT at least up to 27 years; for HPV between 35-50 years, since persisting HR-HPV infection is responsible of high-grade lesions