Phase diagram of patchy colloids: towards empty liquids

We report theoretical and numerical evaluations of the phase diagram for patchy colloidal particles of new generation. We show that the reduction of the number of bonded nearest neighbours offers the possibility of generating liquid states (i.e. states with temperature $T$ lower than the liquid-gas critical temperature) with a vanishing occupied packing fraction ($\phi$), a case which can not be realized with spherically interacting particles. Theoretical results suggest that such reduction is accompanied by an increase of the region of stability of the liquid phase in the ($T$-$\phi$) plane, possibly favoring the establishment of homogeneous disordered materials at small $\phi$, i.e. stable equilibrium gels.Comment: 4 pages, 4 figures, revised version, accepted in Phys. Rev. Let

Self-Assembly of Patchy Particles into Polymer Chains: A Parameter-Free Comparison between Wertheim Theory and Monte Carlo Simulation

We numerically study a simple fluid composed of particles having a hard-core repulsion, complemented by two short-ranged attractive (sticky) spots at the particle poles, which provides a simple model for equilibrium polymerization of linear chains. The simplicity of the model allows for a close comparison, with no fitting parameters, between simulations and theoretical predictions based on the Wertheim perturbation theory, a unique framework for the analytic prediction of the properties of self-assembling particle systems in terms of molecular parameter and liquid state correlation functions. This theory has not been subjected to stringent tests against simulation data for ordering across the polymerization transition. We numerically determine many of the thermodynamic properties governing this basic form of self-assembly (energy per particle, order parameter or average fraction of particles in the associated state, average chain length, chain length distribution, average end-to-end distance of the chains, and the static structure factor) and find that predictions of the Wertheim theory accord remarkably well with the simulation results

Non—Organ-Specific Autoantibodies in Children with Chronic Hepatitis C: Clinical Significance and Impact on Interferon Treatment

We evaluated the prevalence and clinical significance of non-organ-specific autoantibodies (NOSAs) in 47 hepatitis C virus (HCV)-positive children with abnormal alanine transaminase levels and analyzed the association between NOSAs and virus level, genotype, human leukocyte antigen status, and interferon (IFN) response. Forty-two hepatitis B virus (HBV)-positive children and 25 age- and sex-matched healthy children served as control subjects. NOSAs were found in 34% of the HCV-positive children, 12% of the HBV-positive controls, and none of the healthy control subjects. Liver-kidney microsomal antibody type 1 (LKM1) was detected in 11% of the HCV-positive children but in none of the controls. The HCV load was significantly higher in NOSA-negative than in NOSA-positive children. HCV genotype distribution and human leukocyte antigen alleles were similar, irrespective of NOSA status. Long-term response to IFN therapy was achieved by 18% of the NOSA-positive and 55% of the NOSA-negative subjects. Two LKM1-positive children developed acute, self-limited hepatocellular necrosis while receiving IFN therapy. NOSAs are frequently present in children with hepatitis C, who are less likely to benefit from IFN therapy

D-brane Instantons on the T^6/Z_3 orientifold

We give a detailed microscopic derivation of gauge and stringy instanton generated superpotentials for gauge theories living on D3-branes at Z_3-orientifold singularities. Gauge instantons are generated by D(-1)-branes and lead to Affleck, Dine and Seiberg (ADS) like superpotentials in the effective N=1 gauge theories with three generations of bifundamental and anti/symmetric matter. Stringy instanton effects are generated by Euclidean ED3-branes wrapping four-cycles on T^6/\Z_3. They give rise to Majorana masses in one case and non-renormalizable superpotentials for the other cases. Finally we determine the conditions under which ADS like superpotentials are generated in N=1 gauge theories with adjoints, fundamentals, symmetric and antisymmetric chiral matter.Comment: 31 pages, no figure

Dynamical supersymmetry breaking from unoriented D-brane instantons

We study the non-perturbative dynamics of an unoriented Z_5-quiver theory of GUT kind with gauge group U(5) and chiral matter. At strong coupling the non-perturbative dynamics is described in terms of set of baryon/meson variables satisfying a quantum deformed constraint. We compute the effective superpotential of the theory and show that it admits a line of supersymmetric vacua and a phase where supersymmetry is dynamically broken via gaugino condensation.Comment: 24 pages, 1 figur

Cells migrating to sites of tissue damage in response to the danger signal HMGB1 require NF-κB activation

Tissue damage is usually followed by healing, as both differentiated and stem cells migrate to replace dead or damaged cells. Mesoangioblasts (vessel-associated stem cells that can repair muscles) and fibroblasts migrate toward soluble factors released by damaged tissue. Two such factors are high mobility group box 1 (HMGB1), a nuclear protein that is released by cells undergoing unscheduled death (necrosis) but not by apoptotic cells, and stromal derived factor (SDF)–1/CXCL12. We find that HMGB1 activates the canonical nuclear factor κB (NF-κB) pathway via extracellular signal-regulated kinase phosphorylation. NF-κB signaling is necessary for chemotaxis toward HMGB1 and SDF-1/CXCL12, but not toward growth factor platelet-derived growth factor, formyl-met-leu-phe (a peptide that mimics bacterial invasion), or the archetypal NF-κB–activating signal tumor necrosis factor α. In dystrophic mice, mesoangioblasts injected into the general circulation ingress inefficiently into muscles if their NF-κB signaling pathway is disabled. These findings suggest that NF-κB signaling controls tissue regeneration in addition to early events in inflammation

Stringy instanton corrections to N=2 gauge couplings

We discuss a string model where a conformal four-dimensional N=2 gauge theory receives corrections to its gauge kinetic functions from "stringy" instantons. These contributions are explicitly evaluated by exploiting the localization properties of the integral over the stringy instanton moduli space. The model we consider corresponds to a setup with D7/D3-branes in type I' theory compactified on T4/Z2 x T2, and possesses a perturbatively computable heterotic dual. In the heteoric side the corrections to the quadratic gauge couplings are provided by a 1-loop threshold computation and, under the duality map, match precisely the first few stringy instanton effects in the type I' setup. This agreement represents a very non-trivial test of our approach to the exotic instanton calculus.Comment: 63 pages, 5 figures. V2: final version with minor corrections published on JHEP05(2010)10

Spinning Loop Black Holes

In this paper we construct four Kerr-like spacetimes starting from the loop black hole Schwarzschild solutions (LBH) and applying the Newman-Janis transformation. In previous papers the Schwarzschild LBH was obtained replacing the Ashtekar connection with holonomies on a particular graph in a minisuperspace approximation which describes the black hole interior. Starting from this solution, we use a Newman-Janis transformation and we specialize to two different and natural complexifications inspired from the complexifications of the Schwarzschild and Reissner-Nordstrom metrics. We show explicitly that the space-times obtained in this way are singularity free and thus there are no naked singularities. We show that the transformation move, if any, the causality violating regions of the Kerr metric far from r=0. We study the space-time structure with particular attention to the horizons shape. We conclude the paper with a discussion on a regular Reissner-Nordstrom black hole derived from the Schwarzschild LBH and then applying again the Newmann-Janis transformation.Comment: 18 pages, 18 figure

Non-perturbative effective interactions from fluxes

Motivated by possible implications on the problem of moduli stabilization and other phenomenological aspects, we study D-brane instanton effects in flux compactifications. We focus on a local model and compute non-perturbative interactions generated by gauge and stringy instantons in a N = 1 quiver theory with gauge group U(N_0) x U(N_1) and matter in the bifundamentals. This model is engineered with fractional D3-branes at a C^3/(Z_2 x Z_2) singularity, and its non-perturbative sectors are described by introducing fractional D-instantons. We find a rich variety of instanton-generated F- and D-term interactions, ranging from superpotentials and Beasley-Witten like multi-fermion terms to non-supersymmetric flux-induced instanton interactions.Comment: 37 pages, 7 figures. Final version published on JHEP. Section 4 modified in several points regarding string corrections in absence of fluxes; in particular, section 4.3 is removed. Some other minor changes and two references adde

On the Detection of a Scalar Stochastic Background of Gravitational Waves

In the near future we will witness the coming to a full operational regime of laser interferometers and resonant mass detectors of spherical shape. In this work we study the sensitivity of pairs of such gravitational wave detectors to a scalar stochastic background of gravitational waves. Our computations are carried out both for minimal and non minimal coupling of the scalar fields.Comment: 25 pages, 3 figure