The evolution of the colour-magnitude relation and of the star formation activity in galaxy clusters since z~0.8

We present recent results on the evolution of the colour-magnitude relation and of the star formation activity in galaxy clusters since z~0.8. Results are based on the ESO Distant Cluster Survey (EDisCS) - an ESO large programme aimed at the study of cluster structure and cluster galaxy evolution over a significant fraction of cosmic time - and are discussed in the framework of the current standard paradigm of structure formation.Comment: 8 pages, 5 figure, to appear in ASP Conference Series (Proceedings of the 1st Subaru International Conference "Panoramic Views of Galaxy Formation and Evolution", held in Japan, 10-15 December 2007

Holographic description of boundary gravitons in (3+1) dimensions

Gravity is uniquely situated in between classical topological field theories and standard local field theories. This can be seen in the the quasi-local nature of gravitational observables, but is nowhere more apparent than in gravity's holographic formulation. Holography holds promise for simplifying computations in quantum gravity. While holographic descriptions of three-dimensional spacetimes and of spacetimes with a negative cosmological constant are well-developed, a complete boundary description of zero curvature, four-dimensional spacetime is not currently available. Building on previous work in three-dimensions, we provide a new route to four-dimensional holography and its boundary gravitons. Using Regge calculus linearized around a flat Euclidean background with the topology of a solid hyper-torus, we obtain the effective action for a dual boundary theory which describes the dynamics of the boundary gravitons. Remarkably, in the continuum limit and at large radii this boundary theory is local and closely analogous to the corresponding result in three-dimensions. The boundary effective action has a degenerate kinetic term that leads to singularities in the one-loop partition function that are independent of the discretization. These results establish a rich boundary dynamics for four-dimensional flat holography.Comment: 43 pages, 3 figures, 1 tabl

Organization of aerobactin, hemolysin, and antibacterial resistance genes in lactose negative Escherichia coli strains of serotype O4 isolated from children with dhiarrea

Epidemiologically related, non-lactose-fermenting (NLF) Escherichia coli strains of serotype O4 have been isolated at a high frequency from children with diarrhea in Somalia (M. Nicoletti, F. Superti, C. Conti, A. Calconi, and C. Zagaglia, J. Clin. Microbiol. 26:524-529, 1988). In order to define the virulence potential of these strains, we characterized the replication properties of their high-molecular-weight plasmids and studied the genetic locations and organization of the aerobactin (aer) and hemolysin (hly) determinants encoded by 23 NLF O4 E. coli strains. Southern blot hybridizations, mobilization assays of nonconjugative plasmids, and incompatibility-exclusion experiments conducted with a conjugative incompatibility group FI (IncFI) plasmid showed that (i) 20 out of the 23 strains examined harbor a 160- to 180-kb IncFI plasmid that shares homology with the basic replicons RepFIA, RepFIB, and (except for the plasmid of one strain) RepFIC, and 22 strains also contain a 40- to 140-kb IncFII plasmid sharing homology with the RepFIIA replicon; (ii) the IncFI plasmid is nonconjugative and carries antibiotic resistance genes; (iii) the aer system is located on the IncFI plasmids and/or the chromosomes in the three strains not harboring IncFI, and it is found in an inverted orientation; (iv) the hly determinants are located on the chromosome, and their genetic organization is well conserved and closely resembles that of the reference hemolytic plasmid pHly152; and (v) Hly- mutants obtained by transposon insertion mutagenesis are not cytotoxic to HeLa cell monolayers, indicating that hemolysin is responsible for the high cytotoxic activity we have previously reported for these strains. The structural organization of the plasmid-encoded aer operon, together with the finding that those plasmids also carry antibiotic resistance genes, indicates that the IncFI plasmid of the NLF O4 E. coli strains studied more closely resembles aer-encoding virulence IncFI Salmonella R plasmids than E. coli ColV plasmids. The data presented here cannot rule out whether the strains examined are potentially intestinal or extraintestinal pathogens. Nevertheless, the genetic organization of the virulence genes, together with the epidemiological behavior and the wide spectrum of antibiotic resistance of the NLF O4 E. coli strains, indicates that these strains are structured as typical E. coli pathogenic isolates of human origin