66 research outputs found
The risk of inflammatory bowel disease in patients with axial spondyloarthritis treated with biologic agents : BSRBR-AS and meta-analysis
Funding: The BSRBR-AS is supported by the British Society for Rheumatology and they have received funds for the registry from Pfizer, AbbVie and UCB. These companies have no input in determining the topics for analysis or work involved in undertaking it but do receive an advance copy of the manuscript on which they may make comments. ACKNOWLEDGEMENTS: The original idea for the study was suggested by John Mansfield and discussed with Lesley Kay (both Newcastle upon Tyne Hospitals NHS Foundation Trust). All authors discussed and contributed to designing this study and the analysis plan, which was undertaken by RLB and (updated and) overseen by OR, LED and GJM. Results were reviewed by all authors. GJM, RLB, OR and LED all contributed to drafting the manuscript which was critically reviewed by all authors. RLB undertook this work while a visiting student based at the University of Aberdeen from Ludwig-Maximilians Universität (Munich).Peer reviewedPostprin
New Experimental limit on Optical Photon Coupling to Neutral, Scalar Bosons
We report on the first results of a sensitive search for scalar coupling of
photons to a light neutral boson in the mass range of approximately 1.0
milli-electron volts and coupling strength greater than 10 GeV using
optical photons. This was a photon regeneration experiment using the "light
shining through a wall" technique in which laser light was passed through a
strong magnetic field upstream of an optical beam dump; regenerated laser light
was then searched for downstream of a second magnetic field region optically
shielded from the former. Our results show no evidence for scalar coupling in
this region of parameter space.Comment: pdf-file, 10 pages, 4 figures, submitted to Physical Review Letter
New Experimental Limit on Photon Hidden-Sector Paraphoton Mixing
We report on the first results of a search for optical-wavelength photons
mixing with hypothetical hidden-sector paraphotons in the mass range between
10^-5 and 10^-2 electron volts for a mixing parameter greater than 10^-7. This
was a generation-regeneration experiment using the "light shining through a
wall" technique in which regenerated photons are searched for downstream of an
optical barrier that separates it from an upstream generation region. The new
limits presented here are approximately three times more sensitive to this
mixing than the best previous measurement. The present results indicate no
evidence for photon-paraphoton mixing for the range of parameters investigated.Comment: 9 pages, 3 figure
Исследование закономерностей модификации стали 12Х18Н10Т высокоинтенсивной имплантацией ионов азота
В данной работе представлены результаты по изучению формирования пучков ионов азота и их воздействие на поверхность стали 12Х18Н10Т в условиях компенсации распыления. Также было изучено формирование высокоинтенсивных пучков ионов титана. Впервые описан метод измерения глубины легированной примеси при помощи прибора CALOTEST.This paper presents the results of studying the formation of nitrogen ion beams and their effect on the surface of 12X18H10T steel under conditions of sputtering compensation. The formation of high-intensity beams of titanium ions was also studied. For the first time, a method for measuring the depth of an alloyed impurity using the CALOTEST device is described
First lasing of the Jefferson Lab IR Demo FEL
As reported previously [1], Jefferson Lab is building a free-electron laser capable of generating a continuous wave kilowatt laser beam. The driver-accelerator consists of a superconducting, energy-recovery accelerator. The initial stage of the program was to produce over 100 W of average power with no recirculation. In order to provide maximum gain the initial wavelength was chosen to be 5 mu-m and the initial beam energy was chosen to be 38.5 MeV. On June 17, 1998, the laser produced 155 Watts cw power at the laser output with a 98% reflective output coupler. On July 28th, 311 Watts cw power was obtained using a 90% reflective output coupler. A summary of the commissioning activities to date as well as some novel lasing results will be summarized in this paper. Present work is concentrated on optimizing lasing at 5 mu-m, obtaining lasing at 3 mu-m, and commissioning the recirculation transport in preparation for kilowatt lasing this fall
Axion Searches with Helioscopes and astrophysical signatures for axion(-like) particles
The first part reviews the working mechanisms, capabilities and performance
of axion helioscopes, including the achieved results so far. The 2nd part is
observationally driven. New simulation results obtained with the Geant4 code
reconstruct spectral shape of solar X-ray spectra, and their isotropic emission
and lateral size. The derived rst mass of the axion(-like) particles is ~10meV.
The axion interaction with magnetic field gradient is a generic theoretical
suggestion that could reconcile present limits with relevant solar X-ray
activity. A short outlook of the experimentally expanding solar axion field is
given.Comment: 31 pages, 18 figures. Aded 1 author, updated references. Accepted for
the special issue of NJP on dark matter (July 2009
The epithelial cholinergic system of the airways
Acetylcholine (ACh), a classical transmitter of parasympathetic nerve fibres in the airways, is also synthesized by a large number of non-neuronal cells, including airway surface epithelial cells. Strongest expression of cholinergic traits is observed in neuroendocrine and brush cells but other epithelial cell types—ciliated, basal and secretory—are cholinergic as well. There is cell type-specific expression of the molecular pathways of ACh release, including both the vesicular storage and exocytotic release known from neurons, and transmembrane release from the cytosol via organic cation transporters. The subcellular distribution of the ACh release machineries suggests luminal release from ciliated and secretory cells, and basolateral release from neuroendocrine cells. The scenario as known so far strongly suggests a local auto-/paracrine role of epithelial ACh in regulating various aspects on the innate mucosal defence mechanisms, including mucociliary clearance, regulation of macrophage function and modulation of sensory nerve fibre activity. The proliferative effects of ACh gain importance in recently identified ACh receptor disorders conferring susceptibility to lung cancer. The cell type-specific molecular diversity of the epithelial ACh synthesis and release machinery implies that it is differently regulated than neuronal ACh release and can be specifically targeted by appropriate drugs
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