1 research outputs found
In Vivo Computed Tomography/Photoacoustic Imaging and NIR-Triggered Chemo–Photothermal Combined Therapy Based on a Gold Nanostar‑, Mesoporous Silica‑, and Thermosensitive Liposome-Composited Nanoprobe
Safe multifunctional
nanoplatforms that have multiple therapeutic functions integrated
with imaging capabilities are highly desired for biomedical applications.
In this paper, targeted chemo–photothermal synergistic therapy
and photoacoustic/computed tomography imaging of tumors were achieved
by one novel multifunctional nanoprobe (GMS/DOX@SLB-FA); it was composed
of a gold nanostar core and a doxorubicin (DOX)-loaded mesoporous
silica shell (GMS), which was coated with a folic acid (FA)-modified
thermosensitively supported lipid bilayer (SLB-FA) as a gatekeeper.
The multifunctional probe had perfect dispersion and stability; 2.1
nm mesoporous pores and 208 nm hydration particle sizes were obtained.
In vitro studies indicated that the drug-loaded probe had excellent
ability to control the release of DOX, with 71.98 ± 2.52% cumulative
release after laser irradiation, which was significantly higher than
that of unirradiated control group. A survival rate of 72.75 ±
4.37% of HeLa cells at 57.75 μg/mL probe also demonstrated the
low cytotoxicity of the targeted probe. Both in vitro and in vivo
results showed that the probe could achieve targeted photoacoustic
imaging of tumors because of the fact that the FA-modified probe could
specifically recognize the overexpressed FA receptors on tumor cells;
meanwhile, the probe could also achieve the chemo–photothermal
synergistic therapy of tumors through controlling the drug release
from mesoporous channels by a near-infrared laser. Therefore, the
probe had great potential in the early diagnosis and treatment of
cancer