5 research outputs found
Novel euglycemic and hypolipidemic agents: Pyridine containing unsaturated thiazolidinediones
403-406Pyridyl containing
2,4-thiazolidinediones having cyclic amine as linker have been synthesized.
Both unsaturated thiazolidinedione
<span style="font-size:15.5pt;
mso-bidi-font-size:8.5pt;font-family:" times="" new="" roman";mso-fareast-font-family:="" "times="" roman";mso-ansi-language:en-us;mso-fareast-language:en-us;="" mso-bidi-language:ar-sa"="">6<span style="font-size:15.5pt;mso-bidi-font-size:
8.5pt;font-family:" times="" new="" roman";mso-fareast-font-family:"times="" roman";="" mso-ansi-language:en-us;mso-fareast-language:en-us;mso-bidi-language:ar-sa"="">
and saturated thiazolidinedione 5 and their various salts have been evaluated
in db/db mice for euglycemic and hypolipidemic effects. The maleate salt of TZD
6a is found to be a very potent euglycemic
and hypolipidemic compound.</span