1,090 research outputs found
Slip of grip of a molecular motor on a crowded track: Modeling shift of reading frame of ribosome on RNA template
We develop a stochastic model for the programmed frameshift of ribosomes
synthesizing a protein while moving along a mRNA template. Normally the reading
frame of a ribosome decodes successive triplets of nucleotides on the mRNA in a
step-by-step manner. We focus on the programmed shift of the ribosomal reading
frame, forward or backward, by only one nucleotide which results in a fusion
protein; it occurs when a ribosome temporarily loses its grip to its mRNA
track. Special "slippery" sequences of nucleotides and also downstream
secondary structures of the mRNA strand are believed to play key roles in
programmed frameshift. Here we explore the role of an hitherto neglected
parameter in regulating -1 programmed frameshift. Specifically, we demonstrate
that the frameshift frequency can be strongly regulated also by the density of
the ribosomes, all of which are engaged in simultaneous translation of the same
mRNA, at and around the slippery sequence. Monte Carlo simulations support the
analytical predictions obtained from a mean-field analysis of the stochastic
dynamics.Comment: This is an author-created, un-copyedited final version of an article
published in EP
Study of young stellar objects and associated filamentary structures in the inner Galaxy
Young Stellar Objects (YSOs) in the inner Galactic region
and are studied using GLIMPSE images and GLIMPSE data
catalogue. A total number of 1107 Class I and 1566 Class II sources are
identified in this Galactic region. With the help of GLIMPSE 5.8 m & 8
m images, we have identified the presence of 10 major star forming sites
in the Galactic midplane, of which 8 of them are filamentary while 2 are
possible clusters of Class I & II sources. The length of the identified
filaments are estimated as 8'-33' ( 9 - 56 pc). Occurrence of
Hub-Filamentary System (HFS) is observed in many filamentary star forming
sites. Most of the Class I sources are found to be aligned along the length of
these filamentary structures, while Class II sources have a random
distribution. Mass and age distribution of 425 Class I and 241 Class II sources
associated with filaments & clusters are studied through their SED analysis.
Most of the Class I sources detected have mass 8M, while Class II
sources have relatively low mass regime. Class I sources have ages 0.5
Myr, while Class II sources have ages in the range 0.1 - 3 Myr. Along
with the help of high mass star forming tracers, we demonstrate that the 10
regions studied here are forming a large number of high-mass stars.Comment: 19 pages, 18 figures. Accepted for publication in MNRA
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Beyond English : translating modernism in the global south
textMy title echoes Agha Shahid Aliās sentiment of needing to move beyond the linguistic nationalism of āEnglishā toward a more varied understanding of Anglophone writing within multiple contexts in the world. In three theoretical case studies from four linguistic and literary traditions (English, Bengali, Spanish, and Hindi-Urdu), I explore the dimensions and definitions of comparative Anglophone and world literature, comparative poetics, and a comparative study of novels ā in the global postcolonial world. I focus on moments of translatability and untranslatability to question traditional models for studies in English and comparative literature that do not account for translation. Each of my chapters shows how texts in the āoriginalā or ātranslationā do not always circulate from a homogenized metropolitan center to a marginalized periphery, and unlike in the elite North American and Parisian world where untranslatability often inspires terror and loss of language, translations can act as connecting forces that create organic dialogue in the global south on modernism and postcolonial discourses that go beyond Europe and AmericaComparative Literatur
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