3 research outputs found
Exacerbation of Influenza Virus Infections in Mice by Intranasal Treatments and Implications for Evaluation of Antiviral Drugs
Exploring the Interactions of Unsaturated Glucuronides with Influenza Virus Sialidase
A series of C3 O-functionalized 2-acetamido-2-deoxy-?4-߭D-glucuronides were synthesized to explore noncharge interactions in subsite 2 of the in?uenza virus sialidase active site. In complex with A/N8 sialidase, the parent compound (C3 OH) inverts its solution conformation to bind with all substituents well positioned in the active site. The parent compound inhibits in?uenza virus sialidase at a sub-占level; the introduction of small alkyl substituents or an acetyl group at C3 is also tolerated.Office of the Snr Dep Vice Chancellor, Institute for GlycomicsNo Full Tex
Exploring the Interactions of Unsaturated Glucuronides with Influenza Virus Sialidase
A series of C3 <i>O</i>-functionalized 2-acetamido-2-deoxy-Δ<sup>4</sup>-β-d-glucuronides were synthesized to explore
noncharge interactions in subsite 2 of the influenza virus sialidase
active site. In complex with A/N8 sialidase, the parent compound (C3
OH) inverts its solution conformation to bind with all substituents
well positioned in the active site. The parent compound inhibits influenza
virus sialidase at a sub-μM level; the introduction of small
alkyl substituents or an acetyl group at C3 is also tolerated