A decade of letrozole: FACE

Third-generation nonsteroidal aromatase inhibitors (AIs), letrozole and anastrozole, are superior to tamoxifen as initial therapy for early breast cancer but have not been directly compared in a head-to-head adjuvant trial. Cumulative evidence suggests that AIs are not equivalent in terms of potency of estrogen suppression and that there may be differences in clinical efficacy. Thus, with no data from head-to-head comparisons of the AIs as adjuvant therapy yet available, the question of whether there are efficacy differences between the AIs remains. To help answer this question, the Femara versus Anastrozole Clinical Evaluation (FACE) is a phase IIIb open-label, randomized, multicenter trial designed to test whether letrozole or anastrozole has superior efficacy as adjuvant treatment of postmenopausal women with hormone receptor (HR)- and lymph node-positive breast cancer. Eligible patients (target accrual, N = 4,000) are randomized to receive either letrozole 2.5 mg or anastrozole 1 mg daily for up to 5 years. The primary objective is to compare disease-free survival at 5 years. Secondary end points include safety, overall survival, time to distant metastases, and time to contralateral breast cancer. The FACE trial will determine whether or not letrozole offers a greater clinical benefit to postmenopausal women with HR+ early breast cancer at increased risk of early recurrence compared with anastrozole

Design, Performance and Calibration of the CMS Forward Calorimeter Wedges

We report on the test beam results and calibration methods using charged particles of the CMS Forward Calorimeter (HF). The HF calorimeter covers a large pseudorapidity region (3\l |\eta| \le 5), and is essential for large number of physics channels with missing transverse energy. It is also expected to play a prominent role in the measurement of forward tagging jets in weak boson fusion channels. The HF calorimeter is based on steel absorber with embedded fused-silica-core optical fibers where Cherenkov radiation forms the basis of signal generation. Thus, the detector is essentially sensitive only to the electromagnetic shower core and is highly non-compensating (e/h \approx 5). This feature is also manifest in narrow and relatively short showers compared to similar calorimeters based on ionization. The choice of fused-silica optical fibers as active material is dictated by its exceptional radiation hardness. The electromagnetic energy resolution is dominated by photoelectron statistics and can be expressed in the customary form as a/\sqrt{E} + b. The stochastic term a is 198% and the constant term b is 9%. The hadronic energy resolution is largely determined by the fluctuations in the neutral pion production in showers, and when it is expressed as in the electromagnetic case, a = 280% and b = 11%

Minority ion current drive and sensitivity of relative positioning of cyclotron resonance layer and inversion radius on sawtooth control

SIGLEAvailable from British Library Document Supply Centre- DSC:4672.2625(JET-R--93/06) / BLDSC - British Library Document Supply CentreGBUnited Kingdo

Minority ion current drive and sensitivity of relative positioning of cyclotron resonance layer and inversion radius on sawtooth control

SIGLEAvailable from British Library Document Supply Centre- DSC:4672.2625(JET-R--93/06) / BLDSC - British Library Document Supply CentreGBUnited Kingdo

Launching fast waves in large devices

SIGLEAvailable from British Library Document Supply Centre- DSC:4672.262(JET-P--93/105) / BLDSC - British Library Document Supply CentreGBUnited Kingdo

Analysis of bulk ion heating with ICRH in JET high-performance plasmas

SIGLEAvailable from British Library Document Supply Centre-DSC:4672.262(98/81) / BLDSC - British Library Document Supply CentreGBUnited Kingdo

Present and future JET ICRF antennae

SIGLEAvailable from British Library Document Supply Centre- DSC:4672.262(JET-P--92/46) / BLDSC - British Library Document Supply CentreGBUnited Kingdo