Discovery prospects of a light charged Higgs near the fermiophobic region of Type-I 2HDM

Abstract Determining if the SM-like Higgs is part of an extended Higgs sector is the most important question to be asked after discovery. A light charged Higgs boson with mass smaller than the sum of top and bottom quarks is naturally allowed in Type-I two Higgs doublet model and can be produced in association with neutral scalars for large parts of parameter space at the LHC. Such low mass charged scalars typically have dominant decays to the fermionic modes viz. τν and cs. However in the presence of light neutral scalar (φ), the charged Higgs boson has a substantial branching fraction into the bosonic decay modes H ± → W (*) φ. Identifying the heavier neutral Higgs (H) with the observed 125 GeV Higgs and working in the limit M H ± ≈ M A $${M}_{H^{\pm }}\approx {M}_A$$ , we examine charged Higgs production and decay in the bosonic mode pp → H ± h → W (∗) hh. The presence of two light Higgses (h) is then the key to identifying charged Higgs production. The light Higgs branching ratio is largely dominated by the b b ¯ $$b\overline{b}$$ mode except when close to the fermiophobic limit. Here, the rates into b b ¯ $$b\overline{b}$$ and γγ can be comparable and we can use the γγb b ¯ $$\gamma \gamma b\overline{b}$$ signature. This signature is complementary to the hh → 4γ which has been previously discussed in literature. Using the lepton from the W boson, we demonstrate with a cut-and-count analysis that both the new light neutral Higgs as well as charged Higgs can be probed with reasonable significance at 13.6 TeV LHC with 300-3000 fb −1 of integrated luminosity

Phenomenological analysis of multi-pseudoscalar mediated dark matter models

International audienceNon-minimal simplified extensions of the Standard Model have gained considerable currency in the context of dark matter searches at the LHC, since they predict enhanced mono-Higgs and mono-W/Z signatures over large parts of the parameter space. However, these non-minimal models obviously lack the simplicity and directness of the original simplified models, and are more heavily dependent on the model assumptions. We propose to classify these models generically on the basis of additional mediator(s) and dark matter particles. As an example, we take up a scenario involving multiple pseudoscalar mediators, and a single Dirac dark matter particle, the latter being a popular introduction to ensure ultraviolet completion of theories with multiple pseudoscalar fields. In the chosen scenario, we discuss the viable channels and signatures of relevance at the future runs of the LHC. These are then compared with the minimal simplified scenarios and distinguishing features are pinpointed

Establishment and Culture of Patient-Derived Breast Organoids

Breast cancer is a complex disease that has been classified into several different histological and molecular subtypes. Patient-derived breast tumor organoids developed in our laboratory consist of a mix of multiple tumor-derived cell populations, and thus represent a better approximation of tumor cell diversity and milieu than the established 2D cancer cell lines. Organoids serve as an ideal in vitro model, allowing for cell-extracellular matrix interactions, known to play an important role in cell-cell interactions and cancer progression. Patient-derived organoids also have advantages over mouse models as they are of human origin. Furthermore, they have been shown to recapitulate the genomic, transcriptomic as well as metabolic heterogeneity of patient tumors; thus, they are capable of representing tumor complexity as well as patient diversity. As a result, they are poised to provide more accurate insights into target discovery and validation and drug sensitivity assays. In this protocol, we provide a detailed demonstration of how patient-derived breast organoids are established from resected breast tumors (cancer organoids) or reductive mammoplasty-derived breast tissue (normal organoids). This is followed by a comprehensive account of 3D organoid culture, expansion, passaging, freezing, as well as thawing of patient-derived breast organoid cultures

Evaluation of service quality in family planning clinics in Lusaka, Zambia

OBJECTIVE: To determine the quality of contraceptive services in family planning clinics in Lusaka, Zambia using a standardized approach. STUDY DESIGN: We utilized the Quick Investigation of Quality, a cross-sectional survey tool consisting of a facility assessment, client-provider observation, and client exit interview, in public-sector family planning clinics. Data were collected on availability of seven contraceptive methods, information given to clients, interpersonal relations between providers and clients, providers’ technical competence, and mechanisms for continuity and follow-up. RESULTS: Data were collected from five client-provider observations and client exit interviews in each of six public-sector family planning clinics. All clinics had at least two contraceptive methods continuously available for the preceding six months. Most providers asked clients about concerns with their contraceptive method (80%) and told clients when to return to the clinic (87%). Most clients reported that the provider advised what to do if a problem develops (93%); described possible side effects (89%); explained how to use the method effectively (85%); and told them when to come for follow-up (83%). Clients were satisfied with services received (93%). CONCLUSION(S): This application of the Quick Investigation of Quality showed that the participating family planning clinics in Lusaka, Zambia were prepared to offer high quality services with the available commodities, and clients were satisfied with the received services. Despite the subjective client satisfaction, quality improvement efforts are needed to increase contraceptive availability. IMPLICATIONS: Although clients perceived the quality of care received to be high, family planning service quality could be improved to continuously offer the full spectrum of contraceptive options. The Quick Investigation of Quality was easily implemented in Lusaka, Zambia, and this simple approach could be utilized in a variety of settings as a modality for quality improvement

Report from Working Group 3: Beyond the Standard Model physics at the HL-LHC and HE-LHC

This is the third out of five chapters of the final report [1] of the Workshop on Physics at HL-LHC, and perspectives on HE-LHC [2]. It is devoted to the study of the potential, in the search for Beyond the Standard Model (BSM) physics, of the High Luminosity (HL) phase of the LHC, defined as $3$ ab$^{-1}$ of data taken at a centre-of-mass energy of 14 TeV, and of a possible future upgrade, the High Energy (HE) LHC, defined as $15$ ab$^{-1}$ of data at a centre-of-mass energy of 27 TeV. We consider a large variety of new physics models, both in a simplified model fashion and in a more model-dependent one. A long list of contributions from the theory and experimental (ATLAS, CMS, LHCb) communities have been collected and merged together to give a complete, wide, and consistent view of future prospects for BSM physics at the considered colliders. On top of the usual standard candles, such as supersymmetric simplified models and resonances, considered for the evaluation of future collider potentials, this report contains results on dark matter and dark sectors, long lived particles, leptoquarks, sterile neutrinos, axion-like particles, heavy scalars, vector-like quarks, and more. Particular attention is placed, especially in the study of the HL-LHC prospects, to the detector upgrades, the assessment of the future systematic uncertainties, and new experimental techniques. The general conclusion is that the HL-LHC, on top of allowing to extend the present LHC mass and coupling reach by $20-50\%$ on most new physics scenarios, will also be able to constrain, and potentially discover, new physics that is presently unconstrained. Moreover, compared to the HL-LHC, the reach in most observables will, generally more than double at the HE-LHC, which may represent a good candidate future facility for a final test of TeV-scale new physics