Characterizing Surface Properties of Aggregates Used in Hot Mix Asphalt

Physical and chemical properties of aggregates at the micro scale strongly impact the adhesive bond (strength and durability) between bitumen and aggregate. These properties include surface free energy, chemical interaction potential, and specific surface area. This report describes testing methods developed for the Universal Sorption Device (USD), the Wilhelmy Plate (WP), and the microcalorimeter (MC) to measure these surface properties of aggregates. Test results from five different asphalt binders and nine different aggregates are presented to demonstrate how these surface properties can be used to: (1) select combinations of bitumen and aggregates that are more resistant to moisture damage, (2) select additives that can be used to improve the performance of asphalt mixtures based on the physico-chemical nature of the bitumen and aggregate, and (3) predict the resistance of the mixture to moisture-induced damage.Aggregates Foundation for Technology, Research, and Education (AFTRE)Civil, Architectural, and Environmental Engineerin

Development of methods to quantify bitumen-aggregate adhesion and loss of adhesion due to water

Moisture induced damage of hot mix asphalt pavements has a significant economic impact in terms of excessive maintenance and rehabilitation costs. The moisture sensitivity of an asphalt mix depends on the combined effects of material properties, mixture design parameters, loading conditions and environmental factors. Traditional methods to assess moisture sensitivity of asphalt mixes rely on mechanical tests that evaluate the mix as a whole. These methods do not measure material properties and their role in moisture sensitivity of the mix independently. This information is very important to select materials resistant to moisture induced damage, or to modify locally available materials to improve their resistance to moisture damage for economic reasons. The objective of this research is to develop experimental and analytical tools to characterize important material properties that influence the moisture sensitivity of asphalt mixes. Quality of adhesion between the aggregate and bitumen binder in wet and dry conditions plays an important role on the moisture sensitivity of the asphalt mix. A part of this research work was to develop the Wilhelmy plate method and the Universal Sorption Device to measure the surface free energy components of the bitumen and aggregate with adequate precision and accuracy, respectively. Surface energy of these materials was used to identify parameters based on thermodynamics that can quantify their interfacial adhesion and propensity to debond in the presence of water. The thermodynamic parameters were shown to correlate well with the moisture sensitivity of asphalt mixes determined from laboratory tests. Specific surface areas of the aggregates were also used to account for the influence of mechanical interlocking at the micro scale. In some mixes, chemical bonding also contributes to the adhesion between bitumen and aggregate. The use of a micro calorimeter was introduced in this research as a versatile and fast tool to quantify the combined effects of physical and chemical adhesion between these materials

Capacity strengthening in malaria research: the Gates Malaria Partnership.

The Gates Malaria Partnership (GMP) includes five African and four European partner institutions. Its research programme has five priority areas involving an extensive range of field-based studies. GMP research has contributed significantly to the development of new research consortia investigating strategies for improving means of malaria control, and has already had an impact on policy and practice. A substantial investment in innovative training activities in malaria has enhanced knowledge and practice of malaria control at all levels from policy making to local community involvement. Capacity development, notably through a PhD programme, has been an underlying feature of all aspects of the programme

Travel and the emergence of high-level drug resistance in Plasmodium falciparum in southwest Uganda: results from a population-based study.

BACKGROUND: The I164L mutation on the dhfr gene confers high level resistance to sulfadoxine-pyrimethamine (SP) but it is rare in Africa except in a cluster of reports where prevalence >10% in highland areas of southwest Uganda and eastern Rwanda. The occurrence of the dhfr I164L mutation was investigated in community surveys in this area and examined the relationship to migration. METHODS: A cross-sectional prevalence survey was undertaken in among villages within the catchment areas of two health facilities in a highland site (Kabale) and a highland fringe site (Rukungiri) in 2007. Sociodemographic details, including recent migration, were collected for each person included in the study. A total of 206 Plasmodium falciparum positive subjects were detected by rapid diagnostic test; 203 in Rukungiri and 3 in Kabale. Bloodspot samples were taken and were screened for dhfr I164L. RESULTS: Sequence analysis confirmed the presence of the I164L mutations in twelve P. falciparum positive samples giving an estimated prevalence of 8.6% in Rukungiri. Of the three parasite positive samples in Kabale, none had I164L mutations. Among the twelve I164L positives three were male, ages ranged from 5 to 90 years of age. None of those with the I164L mutation had travelled in the 8 weeks prior to the survey, although three were from households from which at least one household member had travelled during that period. Haplotypes were determined in non-mixed infections and showed the dhfr I164L mutation occurs in both as a N51I + S108N + I164L haplotype (n = 2) and N51I + C59R + S108N + I164L haplotype (n = 5). Genotyping of flanking microsatellite markers showed that the I164L occurred independently on the triple mutant (N51I, C59R + S108N) and double mutant (N51I + S108N) background. CONCLUSIONS: There is sustained local transmission of parasites with the dhfr I164L mutation in Rukungiri and no evidence to indicate its occurrence is associated with recent travel to highly resistant neighbouring areas. The emergence of a regional cluster of I164L in SW Uganda and Rwanda indicates that transmission of I164L is facilitated by strong drug pressure in low transmission areas potentially catalysed in those areas by travel and the importation of parasites from relatively higher transmission settings

Modeling and parametric optimization of 3D tendon-sheath actuator system for upper limb soft exosuit

This paper presents an analysis of parametric characterization of a motor driven tendon-sheath actuator system for use in upper limb augmentation for applications such as rehabilitation, therapy, and industrial automation. The double tendon sheath system, which uses two sets of cables (agonist and antagonist side) guided through a sheath, is considered to produce smooth and natural-looking movements of the arm. The exoskeleton is equipped with a single motor capable of controlling both the flexion and extension motions. One of the key challenges in the implementation of a double tendon sheath system is the possibility of slack in the tendon, which can impact the overall performance of the system. To address this issue, a robust mathematical model is developed and a comprehensive parametric study is carried out to determine the most effective strategies for overcoming the problem of slack and improving the transmission. The study suggests that incorporating a series spring into the system's tendon leads to a universally applicable design, eliminating the need for individual customization. The results also show that the slack in the tendon can be effectively controlled by changing the pretension, spring constant, and size and geometry of spool mounted on the axle of motor

Application of Serological Tools and Spatial Analysis to Investigate Malaria Transmission Dynamics in Highland Areas of Southwest Uganda.

Serological markers, combined with spatial analysis, offer a comparatively more sensitive means by which to measure and detect foci of malaria transmission in highland areas than traditional malariometric indicators. Plasmodium falciparum parasite prevalence, seroprevalence, and seroconversion rate to P. falciparum merozoite surface protein-119 (MSP-119) were measured in a cross-sectional survey to determine differences in transmission between altitudinal strata. Clusters of P. falciparum parasite prevalence and high antibody responses to MSP-119 were detected and compared. Results show that P. falciparum prevalence and seroprevalence generally decreased with increasing altitude. However, transmission was heterogeneous with hotspots of prevalence and/or seroprevalence detected in both highland and highland fringe altitudes, including a serological hotspot at 2,200 m. Results demonstrate that seroprevalence can be used as an additional tool to identify hotspots of malaria transmission that might be difficult to detect using traditional cross-sectional parasite surveys or through vector studies. Our study findings identify ways in which malaria prevention and control can be more effectively targeted in highland or low transmission areas via serological measures. These tools will become increasingly important for countries with an elimination agenda and/or where malaria transmission is becoming patchy and focal, but receptivity to malaria transmission remains high

Capitalizing on Construction Records to Identify Relationships between Construction and Long-term Project Performance: Final Report

0-7028TxDOT keeps records of contracted roadway projects in several databases: materials and test records, collected for the quality control / quality assurance program, in the SiteManager (SMGR) database; construction-related information in the Design and Construction Information System (DCIS); and performance measures in the Pavement Analyst (PA) database. The primary objective of this research was to utilize the vast amount of data in these databases to identify relationships between materials and construction records and observed long-term performance of hot-mix asphalt (HMA) pavements. Materials, construction records, and pavement surface conditions were analyzed using traditional regression analysis and new-generation data analysis tools. A few selected projects were also chosen for site inspection. The data analysis shows that binder content, binder grade, and recycled binder content in\ufb02uence a pavement\u2019s performance for a given service life and traf\ufb01c volume. Site visits of a selected sample of projects showed that some pavements were treated with overlays that were not captured by the DCIS or PA databases. Two recommendations are made for TxDOT to continue to bene\ufb01t from the \ufb01ndings of this research project. These are to implement the integrated database into a software platform already available to TxDOT Tableau), and to incorporate elements related to maintenance activities into this integrated database

Development of a Performance-Related Test for Designing Seal Coats [Project Title from Cover]

0-7058TxDOT\u2019s seal coat program is critical to preserving its existing roadway infrastructure and ensuring roadways retain adequate skid resistance. However, sometimes seal coats fail prematurely due to factors such as incompatibility between aggregate and binder and/or binder that has poor durability while meeting other specification requirements. Seal coat design methods focus on the application rates and volumetric approaches to ensure that they are optimal. However, these methods typically do not address the compatibility of and adhesion between binder and aggregate. The overall goal of this project was to identify and develop a laboratory test(s) that can be used to evaluate the expected binder-aggregate adhesion performance and as a screening tool for any seal coat project based on its specific materials (aggregate and asphalt binder or emulsion). The study used modifications of a Sweep Test and Vialit Test to measure seal coat aggregate adhesion and performed these tests in multiple experiments to investigate the effects of binder type, dust, certain types of binder modifiers, and liquid antistrip agents on adhesion characteristics using four different aggregates mineralogies. The lab testing program and a field section evaluation indicated that the Sweep Test best evaluates the binder-aggregate adhesion. The testing also lead to recommended limits for aggregate loss