Formulation And Evaluation Of Gastroretentive Drug Delivery System Of Alfuzosin Hydrochloride

Gastro-retentive drug delivery systems are an approach to prolong gastric residence time, there by targeting site specific drug release in the upper GIT for local or systemic effect. Gastro-retentive drug delivery systems formulations greatly improves the pharmacotherapy of stomach by releasing the drug locally and thus results into high concentration of drug at the gastric mucosa which can be sustained over a longer duration of time Gastro-retentive drug delivery system formulated by direct compression method using (i) Alfuzosin HCL an antihypertensive drug (ii) Polyethylene oxide WSR301 , Hydroxy propyl methyl cellulose K4M and Xanthan gum as polymers (iii) Sodium bicarbonate used as gas generating base . The effect of these polymers concentration was evaluated with respect to Floating Lag Time, Total Floating Time, Matrix integrity, swelling study and In-vitro release behaviors and release kinetics with model fitting. Infrared spectroscopic study confirmed the absence of any drug-polymer interaction. Differential scanning colorometry confirmed melting point, purity of drug and polymers. Incorporation of sodium bicarbonate in the Gastro-retentive drug delivery system proved to be an effective method to achieve desired buoyancy. The designed system, combining excellent buoyant ability and suitable drug release pattern, from the study it was concluded that, controlled release Alfuzosin HCL floating tablets can be achieved with success using direct compression technique